Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs (Q36795136)

From Wikidata

Jump to navigation Jump to search

scientific article published on May 2007

Language	Label	Description	Also known as
English	Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs	scientific article published on May 2007

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

1 reference

Europe PubMed Central

Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

author name string

Bradley L Urquhart

1

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Rommel G Tirona

2

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Richard B Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

publication date

1 May 2007

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

The Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

47

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

566-578

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Phenotype and genotype analysis of debrisoquine hydroxylase (CYP2D6) in a black Zimbabwean population. Reduced enzyme activity and evaluation of metabolic correlation of CYP2D6 probe drugs

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The role of individual human cytochromes P450 in drug metabolism and clinical response

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human drug metabolizing cytochromes P450.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of the novel splicing variants for the hPXR in human livers

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Functional characterization of a novel polymorphism of pregnane X receptor, Q158K, in Chinese subjects

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of a novel polymorphic enhancer of the human CYP3A4 gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Variations of the human glucocorticoid receptor gene (NR3C1): Pathological and in vitro mutations and polymorphisms

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Liganded VDR induces CYP3A4 in small intestinal and colon cancer cells via DR3 and ER6 vitamin D responsive elements.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

CYP2C9 genotypes and dose requirements during the induction phase of oral anticoagulant therapy

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression and induction of CYP2C P450 enzymes in primary cultures of human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Inherited disorders of bilirubin metabolism

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Pharmacological interventions for the treatment of neonatal jaundice.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Orphan nuclear receptor pregnane X receptor sensitizes oxidative stress responses in transgenic mice and cancerous cells

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transporters and drug therapy: implications for drug disposition and disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Drug transport proteins in the liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

MRP2 and 3 in health and disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Breast cancer resistance protein (BCRP/ABCG2).

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

ATP-dependent transport of rosuvastatin in membrane vesicles expressing breast cancer resistance protein

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Peroxisome proliferator-activated receptor gamma-regulated ABCG2 expression confers cytoprotection to human dendritic cells

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Enterohepatic bile salt transporters in normal physiology and liver disease

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechan

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Transporter-mediated influx and efflux mechanisms of pitavastatin, a new inhibitor of HMG-CoA reductase

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Multispecific amphipathic substrate transport by an organic anion transporter of human liver

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptides

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression of the steroid and xenobiotic receptor and its possible target gene, organic anion transporting polypeptide-A, in human breast carcinoma

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Nuclear receptors and the control of metabolism

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The nuclear receptor superfamily: a rosetta stone for physiology

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Evaluation of human liver slices and reporter gene assays as systems for predicting the cytochrome p450 induction potential of drugs in vivo in humans

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Pharmaceutical use of mouse models humanized for the xenobiotic receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The mycoestrogen zearalenone induces CYP3A through activation of the pregnane X receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Functional analysis of four naturally occurring variants of human constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Molecular and functional comparison of 1,25-dihydroxyvitamin D(3) and the novel vitamin D receptor ligand, lithocholic acid, in activating transcription of cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation

1 reference

https://api.crossref.org/works/10.1177%2F0091270007299930

21 January 2018

Identifiers

10.1177/0091270007299930

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 August 2017

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q36795136&oldid=2151496417"