Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases (Q36803757)

16 August 2017

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title

Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases (English)

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16 August 2017

Robert A Casero

1

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PubMed ID

17464296

16 August 2017

Laurence J Marton

series ordinal

2

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16 August 2017

1 May 2007

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Nature Reviews Drug Discovery

16 August 2017

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16 August 2017

6

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16 August 2017

373-390

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16 August 2017

5

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https://scigraph.springernature.com/pub.10.1038/nrd2243

16 August 2017

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cites work

Polyamines and cancer: old molecules, new understanding

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Polyamines as targets for therapeutic intervention

31 March 2020

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Spermine Binds in Solution to the TpsiC Loop of tRNA(Phe): Evidence from a 750 MHz (1)H-NMR Analysis

31 March 2020

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Implications and concepts of polyamine-nucleic acid interactions

31 March 2020

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The natural polyamine spermine functions directly as a free radical scavenger.

31 March 2020

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The polyamine binding site in inward rectifier K+ channels.

31 March 2020

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The post-translational synthesis of a polyamine-derived amino acid, hypusine, in the eukaryotic translation initiation factor 5A (eIF5A)

31 March 2020

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Molecular cloning, expression, and structural prediction of deoxyhypusine hydroxylase: a HEAT-repeat-containing metalloenzyme

31 March 2020

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Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells

31 March 2020

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Activation of the proto-oncogene c-myc and c-fos by c-ras: involvement of polyamines

31 March 2020

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Mnt loss triggers Myc transcription targets, proliferation, apoptosis, and transformation

31 March 2020

1 reference

Regulation of ornithine decarboxylase

31 March 2020

1 reference

Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme

31 March 2020

1 reference

Regulation of cellular polyamines by antizyme

31 March 2020

1 reference

Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase

31 March 2020

1 reference

Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

31 March 2020

1 reference

The ornithine decarboxylase gene is a transcriptional target of c-Myc

31 March 2020

1 reference

Aminopropyltransferases: function, structure and genetics

31 March 2020

1 reference

Molecular cloning of a cDNA encoding human spermine synthase

31 March 2020

1 reference

Human spermidine synthase: cloning and primary structure

31 March 2020

1 reference

Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase

31 March 2020

1 reference

Polyamine oxidase (rat liver).

31 March 2020

1 reference

Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion

31 March 2020

1 reference

Cloning, sequencing, and heterologous expression of the murine peroxisomal flavoprotein, N1-acetylated polyamine oxidase

31 March 2020

1 reference

Properties of recombinant human N1-acetylpolyamine oxidase (hPAO): potential role in determining drug sensitivity

31 March 2020

1 reference

Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin

31 March 2020

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Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

31 March 2020

1 reference

Heterologous expression and characterization of mouse spermine oxidase

31 March 2020

1 reference

Mouse spermine oxidase: a model of the catalytic cycle and its inhibition by N,N1-bis(2,3-butadienyl)-1,4-butanediamine.

31 March 2020

1 reference

Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis

31 March 2020

1 reference

A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism

31 March 2020

1 reference

Proteoglycan involvement in polyamine uptake.

31 March 2020

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Glypican-1 is a vehicle for polyamine uptake in mammalian cells: a pivital role for nitrosothiol-derived nitric oxide

31 March 2020

1 reference

31 March 2020

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Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective Enzyme Inhibitors

31 March 2020

1 reference

Ornithine decarboxylase as an enzyme target for therapy

31 March 2020

1 reference

Inhibitors of polyamine metabolism: review article

31 March 2020

1 reference

(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase

31 March 2020

1 reference

alpha-(Fluoromethyl)dehydroornithine and alpha-(fluoromethyl)dehydroputrescine analogues as irreversible inhibitors of ornithine decarboxylase

31 March 2020

1 reference

Initial characterization of a HTC cell variant partially resistant to the anti-proliferative effect of ornithine decarboxylase inhibitors

31 March 2020

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Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

31 March 2020

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Analogues of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site

31 March 2020

1 reference

Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells

31 March 2020

1 reference

Polyamines are necessary for the survival of human small-cell lung carcinoma in culture

31 March 2020

1 reference

Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis

31 March 2020

1 reference

Phase I trial of alpha-difluoromethyl ornithine (DFMO) and methylglyoxal bis (guanylhydrazone) (MGBG) in patients with advanced prostatic cancer

31 March 2020

1 reference

A phase II study of alpha-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma

31 March 2020

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Phase I-II clinical trial with alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.

31 March 2020

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Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine

31 March 2020

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Phase I study of combined alpha interferon, alpha difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy

31 March 2020

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Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme

31 March 2020

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Efficacy and toxicity of eflornithine for treatment of Trypanosoma brucei gambiense sleeping sickness

31 March 2020

1 reference

Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine

31 March 2020

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Structural elements of ornithine decarboxylase required for intracellular degradation and polyamine-dependent regulation

31 March 2020

1 reference

Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma

31 March 2020

1 reference

Methyl glyoxal bis(guanylhydrazone) as a potent inhibitor of mammalian and yeast S-adenosylmethionine decarboxylases

31 March 2020

1 reference

Population pharmacokinetics/toxicodynamics (PK/TD) relationship of SAM486A in phase I studies in patients with advanced cancers

31 March 2020

1 reference

A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours.

31 March 2020

1 reference

Phase I and pharmacokinetic study of the polyamine synthesis inhibitor SAM486A in combination with 5-fluorouracil/leucovorin in metastatic colorectal cancer

31 March 2020

1 reference

Clinical efficacy, tolerability, and safety of SAM486A, a novel polyamine biosynthesis inhibitor, in patients with relapsed or refractory non-Hodgkin's lymphoma: results from a phase II multicenter study

31 March 2020

1 reference

Multi-centre Phase II trial of the polyamine synthesis inhibitor SAM486A (CGP48664) in patients with metastatic melanoma

31 March 2020

1 reference

Effect of magnesium ions on the inhibition of S-adenosylmethionine decarboxylase from Escherichia coli by [2-(amino-oxy)ethyl](5'-deoxyadenosin-5'-yl)(methyl)sulphonium .

31 March 2020

1 reference

Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-([

31 March 2020

1 reference

The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase

31 March 2020

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Irreversible inhibition of rat S-adenosylmethionine decarboxylase by 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine.

31 March 2020

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Irreversible inhibition of human S-adenosylmethionine decarboxylase by the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4- methylsulfonio-2-cyclopentene (AdoMac)

31 March 2020

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Preparation of the pure diastereomeric forms of S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-methylsulfonio-2-cyclopentene and their evaluation as irreversible inhibitors of S-adenosylmethionine decarboxylase from Escherichia coli.

31 March 2020

1 reference

S-(5'-deoxy-5'-adenosyl)-1-ammonio-4-(methylsulfonio)-2-cyclopentene: A potent, enzyme-activated irreversible inhibitor of S-adenosylmethionine decarboxylase

31 March 2020

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Differential inhibition of mammalian aminopropyltransferase activities

31 March 2020

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Studies of inhibition of rat spermidine synthase and spermine synthase

31 March 2020

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Polyamine Synthesis in Mammalian Tissues. Isolation and Characterization of Spermine Synthase from Bovine Brain

31 March 2020

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Methylthioadenosine, a potent inhibitor of spermine synthase from bovine brain

31 March 2020

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Specific and potent inhibition of spermidine synthase by the transition-state analog, S-adenosyl-3-thio-1,8-diaminooctane

31 March 2020

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Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism

31 March 2020

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Synthesis and biological evaluation of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase

31 March 2020

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Effect of S-adenosyl-1,12-diamino-3-thio-9-azadodecane, a multisubstrate adduct inhibitor of spermine synthase, on polyamine metabolism in mammalian cells

31 March 2020

1 reference

A perspective of polyamine metabolism

31 March 2020

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Polyamine metabolism and cancer.

31 March 2020

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Enzyme regulation as an approach to interference with polyamine biosynthesis--an alternative to enzyme inhibition

31 March 2020

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Synthesis and biological evaluation of aminopolyamines

31 March 2020

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A comparison of structure-activity relationships between spermidine and spermine analogue antineoplastics

31 March 2020

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Antiproliferative properties of polyamine analogues: a structure-activity study

31 March 2020

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Synthetic polyamine analogs as antineoplastics

31 March 2020

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Oxidation products of polyamines induce mitochondrial uncoupling and cytochrome c release

31 March 2020

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Amine oxidases, programmed cell death, and tissue renewal

31 March 2020

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Oxidation of polyamines and brain injury

31 March 2020

1 reference

The copper-containing amine oxidases: biochemical aspects and functional role

31 March 2020

1 reference

Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein

31 March 2020

1 reference

Mechanisms of spermine toxicity in baby-hamster kidney (BHK) cells. The role of amine oxidases and oxidative stress

31 March 2020

1 reference

High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma

31 March 2020

1 reference

Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase

31 March 2020

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Structure of the human spermidine/spermine N1-acetyltransferase gene

31 March 2020

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Antitumor effects of N-alkylated polyamine analogues in human pancreatic adenocarcinoma models

31 March 2020

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Regulatory and antiproliferative effects of N-alkylated polyamine analogues in human and hamster pancreatic adenocarcinoma cell lines

31 March 2020

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Effects of diethyl spermine analogues in human bladder cancer cell lines in culture

31 March 2020

1 reference

Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis

31 March 2020

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Altered spermidine/spermine N1-acetyltransferase activity as a mechanism of cellular resistance to bis(ethyl)polyamine analogues

31 March 2020

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Properties of the spermidine/spermine N1-acetyltransferase mutant L156F that decreases cellular sensitivity to the polyamine analogue N1, N11-bis(ethyl)norspermine

31 March 2020

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Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells

31 March 2020

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Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs

31 March 2020

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Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct

31 March 2020

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Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine

31 March 2020

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Unusual central nervous system toxicity in a phase I study of N1N11 diethylnorspermine in patients with advanced malignancy.

31 March 2020

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Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies

31 March 2020

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Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer.

31 March 2020

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Combination of 5-fluorouracil and N1,N11-diethylnorspermine markedly activates spermidine/spermine N1-acetyltransferase expression, depletes polyamines, and synergistically induces apoptosis in colon carcinoma cells

31 March 2020

1 reference

Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents.

31 March 2020

1 reference

Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1

31 March 2020

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Synthesis and evaluation of a polyamine phosphinate and phosphonamidate as transition-state analogue inhibitors of spermidine/spermine-N1-acetyltransferase

31 March 2020

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Terminally alkylated polyamine analogues as chemotherapeutic agents.

31 March 2020

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1-(N-alkylamino)-11-(N-ethylamino)-4,8-diazaundecanes: simple synthetic polyamine analogues that differentially alter tubulin polymerization

31 March 2020

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The role of polyamine catabolism in polyamine analogue-induced programmed cell death

31 March 2020

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Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells

31 March 2020

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Role of p53/p21(Waf1/Cip1) in the regulation of polyamine analogue-induced growth inhibition and cell death in human breast cancer cells.

31 March 2020

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Induction of apoptosis in human leukaemic cells by IPENSpm, a novel polyamine analogue and anti-metabolite

31 March 2020

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Effect of spermine synthase on the sensitivity of cells to anti-tumour agents

31 March 2020

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Conformationally restricted analogues of 1N,12N-bisethylspermine: synthesis and growth inhibitory effects on human tumor cell lines

31 March 2020

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cis-Unsaturated analogues of 3,8,13,18,23-pentaazapentacosane (BE-4-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cell lines

31 March 2020

1 reference

Conformationally restricted analogues of 1N,14N-bisethylhomospermine (BE-4-4-4): synthesis and growth inhibitory effects on human prostate cancer cells

31 March 2020

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[(1)N,(12)N]Bis(Ethyl)-cis-6,7-dehydrospermine: a new drug for treatment and prevention of Cryptosporidium parvum infection of mice deficient in T-cell receptor alpha

31 March 2020

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Molecular basis of inward rectification: structural features of the blocker defined by extended polyamine analogs.

31 March 2020

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A novel polyamine analog (SL-11093) inhibits growth of human prostate tumor xenografts in nude mice

31 March 2020

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Suppression and regression of choroidal neovascularization by polyamine analogues

31 March 2020

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Trans-scleral delivery of polyamine analogs for ocular neovascularization

31 March 2020

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Molecular mechanics of the interactions of spermine with DNA: DNA bending as a result of ligand binding

31 March 2020

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Effects of spermine and its cytotoxic analogs on nucleosome formation on topologically stressed DNA in vitro

31 March 2020

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Polyamine analog bis(ethylamino)-5,10,15-triazanonadecane (BE-4-4-4-4) enhances simian virus 40 late gene expression

31 March 2020

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Long-chain polyamines (oligoamines) exhibit strong cytotoxicities against human prostate cancer cells.

31 March 2020

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Antizyme induction by polyamine analogues as a factor of cell growth inhibition

31 March 2020

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Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells.

31 March 2020

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Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells

31 March 2020

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Medical applications of macrocyclic polyamines

31 March 2020

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Monometallic complexes of 1,4,7,10-tetraazacyclododecane containing an imidazolium side: synthesis, characterization, and their interaction with plasmid DNA.

31 March 2020

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DNA hydrolysis promoted by 1,7-dimethyl-1,4,7,10-tetraazacyclododecane

31 March 2020

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The comparative toxicity of chlorambucil and chlorambucil-spermidine conjugate to BALB/c mice

31 March 2020

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Uptake and cytotoxicity of novel nitroimidazole-polyamine conjugates in Ehrlich ascites tumour cells

31 March 2020

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The effect of polyamine homologation on the transport and cytotoxicity properties of polyamine-(DNA-intercalator) conjugates

31 March 2020

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Influence of polyamine architecture on the transport and topoisomerase II inhibitory properties of polyamine DNA-intercalator conjugates

31 March 2020

1 reference

Synthesis and biological evaluation of N1-(anthracen-9-ylmethyl)triamines as molecular recognition elements for the polyamine transporter

31 March 2020

1 reference

Molecular requirements for targeting the polyamine transport system. Synthesis and biological evaluation of polyamine-anthracene conjugates

31 March 2020

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Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines.

31 March 2020

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

31 March 2020

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Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors

31 March 2020

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Structural basis for differential induction of spermidine/spermine N1-acetyltransferase activity by novel spermine analogs

31 March 2020

1 reference

Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.

31 March 2020

1 reference

Recognition of Z-RNA and Z-DNA Determinants by Polyamines in Solution: Experimental and Theoretical Studies

31 March 2020

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Effects of variation in the structure of spermine on the association with DNA and the induction of DNA conformational changes

31 March 2020

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Theoretical models of spermine/DNA interactions

31 March 2020

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Spermine-DNA interactions: a theoretical study

31 March 2020

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Molecular dynamics of spermine-DNA interactions: sequence specificity and DNA bending for a simple ligand

31 March 2020

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Translating the Histone Code

31 March 2020

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Histone deacetylases and cancer: causes and therapies

31 March 2020

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Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

31 March 2020

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Histone deacetylase inhibitors

31 March 2020

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Elevated levels of polyamines alter chromatin in murine skin and tumors without global changes in nucleosome acetylation

31 March 2020

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Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

31 March 2020

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Regulation of LSD1 histone demethylase activity by its associated factors

31 March 2020

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Rapid caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N(1),N(11)-diethylnorspermine

31 March 2020

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Loss of inhibitor of apoptosis proteins as a determinant of polyamine analog-induced apoptosis in human melanoma cells

31 March 2020

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Anti-tumoral effect of native and immobilized bovine serum amine oxidase in a mouse melanoma model

31 March 2020

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Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.

31 March 2020

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Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway.

31 March 2020

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Ca2+ influx via T-type channels modulates PDGF-induced replication of mouse fibroblasts

31 March 2020

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Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells

31 March 2020

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Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels

31 March 2020

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Investigations of the mechanism by which mammalian cell growth is inhibited by N1N12-bis(ethyl)spermine

31 March 2020

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The ornithine decarboxylase gene is essential for cell survival during early murine development

31 March 2020

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Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

31 March 2020

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Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth

31 March 2020

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Genetic approaches to the cellular functions of polyamines in mammals

31 March 2020

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Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice

31 March 2020

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Haploinsufficiency for odc modifies mouse skin tumor susceptibility

31 March 2020

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Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase

31 March 2020

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Genetic manipulation of polyamine catabolism in rodents

31 March 2020

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Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS.

31 March 2020

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K6/ODC transgenic mice as a sensitive model for carcinogen identification

31 March 2020

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Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

31 March 2020

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Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study

31 March 2020

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Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2f1 loss.

31 March 2020

1 reference

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

31 March 2020

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p27 destruction: Cks1 pulls the trigger

31 March 2020

1 reference

Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding

31 March 2020

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Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397.

31 March 2020

1 reference

Structure of a human S-adenosylmethionine decarboxylase self-processing ester intermediate and mechanism of putrescine stimulation of processing as revealed by the H243A mutant

31 March 2020

1 reference

Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target

31 March 2020

1 reference

Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): the first structure of a new sequence family of transferase homologous superfamily

31 March 2020

1 reference

Antizyme2 is a negative regulator of ornithine decarboxylase and polyamine transport

31 March 2020

1 reference

Proteasomal degradation of spermidine/spermine N1-acetyltransferase requires the carboxyl-terminal glutamic acid residues

31 March 2020

1 reference

Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation

31 March 2020

1 reference

Post-transcriptional regulation of the content of spermidine/spermine N1-acetyltransferase by N1N12-bis(ethyl)spermine

31 March 2020

1 reference

Characterization of a Diamine Exporter in Chinese Hamster Ovary Cells and Identification of Specific Polyamine Substrates

31 March 2020

1 reference

Polyamine oxidase, properties and functions

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD2243

1 reference

16 August 2017

1 reference

PubMed ID

17464296