Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view (Q36806808)

16 August 2017

1 reference

title

Termination of TGF-beta superfamily signaling through SMAD dephosphorylation--a functional genomic view (English)

1 reference

16 August 2017

1 reference

Xia Lin

1

1 reference

16 August 2017

Yeguang Chen

series ordinal

2

1 reference

16 August 2017

Anming Meng

series ordinal

3

1 reference

16 August 2017

Xinhua Feng

series ordinal

4

1 reference

16 August 2017

publication date

1 January 2007

1 reference

Journal of Genetics and Genomics

16 August 2017

published in

1 reference

16 August 2017

volume

34

1 reference

16 August 2017

issue

1

1 reference

16 August 2017

page(s)

1-9

1 reference

Smads and early developmental signaling by the TGFbeta superfamily

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

TGF-beta signalling pathways in early Xenopus development.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Intracellular BMP signaling regulation in vertebrates: pathway or network?

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Role of transforming growth factor beta in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Alterations of cell signaling pathways in pancreatic cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Antifibrotic therapy in scleroderma: extracellular or intracellular targeting of activated fibroblasts?

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

TGF-beta signaling: positive and negative effects on tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Lateral signaling enhances TGF-beta response complexity

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Specificity and versatility in tgf-beta signaling through Smads

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Transcriptional control by the TGF-beta/Smad signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

New insights into TGF-beta-Smad signalling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

A human Mad protein acting as a BMP-regulated transcriptional activator

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Signaling inputs converge on nuclear effectors in TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

TGF-beta signaling from receptors to the nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

A Smad transcriptional corepressor

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

p21(WAF1/CIP1) at the switch between the anti-oncogenic and oncogenic faces of TGFbeta.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Mad-related genes in the human

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

DPC4 gene mutation in colitis associated neoplasia

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Somatic alterations of the SMAD-2 gene in human colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Role of Ras and Mapks in TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Integration of Smad and MAPK pathways: a link and a linker revisited

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Inhibition of Smad antiproliferative function by CDK phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Cyclin-dependent kinases regulate the antiproliferative function of Smads

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Repression of Smad4 transcriptional activity by SUMO modification

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

The RING domain of PIASy is involved in the suppression of bone morphogenetic protein-signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Analysis of Smad nucleocytoplasmic shuttling in living cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Importin beta mediates nuclear translocation of Smad 3

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

A novel nuclear export signal in Smad1 is essential for its signaling activity

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

In or out? The dynamics of Smad nucleocytoplasmic shuttling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Nucleocytoplasmic shuttling of signal transducers.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Protein tyrosine phosphatases in the human genome

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Protein serine/threonine phosphatases: life, death, and sleeping.

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

TGF beta signaling in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

Molecular genetics of Marfan syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

The two faces of transforming growth factor beta in carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

From developmental disorder to heritable cancer: it's all in the BMP/TGF-beta family

1 reference

https://api.crossref.org/works/10.1016%2FS1673-8527%2807%2960001-0

7 January 2021

10.1016/S1673-8527(07)60001-0

Identifiers

DOI

1 reference

16 August 2017

1 reference