Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia (Q36837426)

16 August 2017

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia (English)

1 reference

16 August 2017

L Tuohey

8

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Hiromi Tagoh

object named as

H Tagoh

5

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Meinrad Busslinger

object named as

M Busslinger

11

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Stephen L. Nutt

10

object named as

Nutt SL

1 reference

16 August 2017

14

Dickins RA

1 reference

16 August 2017

13

G K Smyth

1 reference

16 August 2017

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M T Witkowski

1

1 reference

16 August 2017

L Cimmino

2

1 reference

16 August 2017

Y Hu

3

1 reference

16 August 2017

T Trimarchi

4

1 reference

16 August 2017

M D McKenzie

6

1 reference

16 August 2017

S A Best

7

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16 August 2017

T A Willson

9

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16 August 2017

I Aifantis

12

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16 August 2017

language of work or name

English

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publication date

6 February 2015

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16 August 2017

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16 August 2017

29

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16 August 2017

6

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16 August 2017

1301-1311

1 reference

https://scigraph.springernature.com/pub.10.1038/leu.2015.27

16 August 2017

0 references

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Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

29 September 2017

1 reference

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A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

29 September 2017

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Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

29 September 2017

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29 September 2017

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c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells

29 September 2017

1 reference

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The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability

29 September 2017

1 reference

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Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia

29 September 2017

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29 September 2017

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NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.

29 September 2017

1 reference

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Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

29 September 2017

1 reference

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

29 September 2017

1 reference

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Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis

29 September 2017

1 reference

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High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

29 September 2017

1 reference

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Role of Ikaros in T-cell acute lymphoblastic leukemia

29 September 2017

1 reference

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A rapid and scalable system for studying gene function in mice using conditional RNA interference

29 September 2017

1 reference

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Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

29 September 2017

1 reference

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Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

29 September 2017

1 reference

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Notch regulation of early thymocyte development

29 September 2017

1 reference

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29 September 2017

1 reference

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Ikaros and Aiolos inhibit pre-B-cell proliferation by directly suppressing c-Myc expression

29 September 2017

1 reference

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29 September 2017

1 reference

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Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia

29 September 2017

1 reference

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Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Ikaros regulates Notch target gene expression in developing thymocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Ikaros represses the transcriptional response to Notch signaling in T-cell development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks

29 September 2017

1 reference

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Ikaros directly represses the notch target gene Hes1 in a leukemia T cell line: implications for CD4 regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

29 September 2017

1 reference

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FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

29 September 2017

1 reference

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The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia

29 September 2017

1 reference

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

29 September 2017

1 reference

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Early hematopoietic lineage restrictions directed by Ikaros.

29 September 2017

1 reference

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Ikaros induces quiescence and T-cell differentiation in a leukemia cell line.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

29 September 2017

1 reference

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Defects in hemopoietic stem cell activity in Ikaros mutant mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Stage-specific control of early B cell development by the transcription factor Ikaros.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Vav promoter-tTA conditional transgene expression system for hematopoietic cells drives high level expression in developing B and T cells.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas.

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4845663

Acute lymphoblastic leukaemia

5 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FLEU.2015.27

The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25655195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25655195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Genetic inactivation of Ikaros is a rare event in human T-ALL

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25655195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2015.27

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

25655195

1 reference