Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. (Q36844694)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27088857%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

title

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer (English)

1 reference

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2 April 2020

1 reference

1

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2 April 2020

Costas A Lyssiotis

2

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2 April 2020

author name string

Ashish Juvekar

3

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2 April 2020

Hai Hu

4

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2 April 2020

John M Asara

5

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2 April 2020

Lewis C Cantley

6

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2 April 2020

Alex Toker

7

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2 April 2020

publication date

18 April 2016

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2 April 2020

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2 April 2020

volume

18

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2 April 2020

issue

5

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2 April 2020

page(s)

572-578

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Cisplatin in cancer therapy: molecular mechanisms of action

2 April 2020

cites work

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

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Oncogenic PI3K mutations lead to NF-κB-dependent cytokine expression following growth factor deprivation

29 September 2017

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Differential effects of AKT1(p.E17K) expression on human mammary luminal epithelial and myoepithelial cells

29 September 2017

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29 September 2017

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Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

29 September 2017

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

29 September 2017

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SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

29 September 2017

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Role of Glutathione in the Regulation of Cisplatin Resistance in Cancer Chemotherapy

29 September 2017

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

29 September 2017

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Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations

29 September 2017

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

29 September 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

29 September 2017

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

29 September 2017

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

29 September 2017

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Is Akt the "Warburg kinase"?-Akt-energy metabolism interactions and oncogenesis

29 September 2017

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A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

29 September 2017

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29 September 2017

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NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.

29 September 2017

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29 September 2017

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29 September 2017

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

29 September 2017

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29 September 2017

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29 September 2017

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27 June 2018

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27 June 2018

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Methods for long-term 17β-estradiol administration to mice.

5 September 2018

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Sulforhodamine B colorimetric assay for cytotoxicity screening

5 September 2018

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A novel model of continuous depletion of glutathione in mice treated with L-buthionine (S,R)-sulfoximine

5 September 2018

1 reference

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Buthionine sulfoximine induced growth inhibition in human lung carcinoma cells does not correlate with glutathione depletion

5 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27088857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27088857

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCB3341

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27088857%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

1 reference

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2 April 2020

PubMed publication ID

27088857

1 reference