Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia (Q36850782)

16 August 2017

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title

Adenomatous polyposis coli (APC) plays multiple roles in the intestinal and colorectal epithelia (English)

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16 August 2017

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Takao Senda

1

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16 August 2017

Akiko Iizuka-Kogo

series ordinal

2

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16 August 2017

Takanori Onouchi

series ordinal

3

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16 August 2017

Atsushi Shimomura

series ordinal

4

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16 August 2017

publication date

18 June 2007

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Medical Molecular Morphology

16 August 2017

published in

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16 August 2017

volume

40

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16 August 2017

issue

2

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16 August 2017

page(s)

68-81

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APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export

16 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS00795-006-0352-5

Piroxicam and acarbose as chemopreventive agents for spontaneous intestinal adenomas in APC gene 1309 knockout mice

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00795-006-0352-5

DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00795-006-0352-5

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 January 2018

1 reference

12 December 2020

APC protein is required for initiation of neuronal differentiation in rat pheochromocytoma PC12 cells

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12 December 2020

Gardner syndrome in a man with an interstitial deletion of 5q.

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12 December 2020

Familial Adenomatous Polyposis

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12 December 2020

Colocalization of APC and DLG at the tips of cellular protrusions in cultured epithelial cells and its dependency on cytoskeletons.

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12 December 2020

Apoptosis and APC in colorectal tumorigenesis

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12 December 2020

Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation

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12 December 2020

Identification of a link between the tumour suppressor APC and the kinesin superfamily

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12 December 2020

Identification of c-MYC as a target of the APC pathway

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12 December 2020

Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

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12 December 2020

Asef, a link between the tumor suppressor APC and G-protein signaling

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12 December 2020

The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules

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12 December 2020

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

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12 December 2020

Association of the APC tumor suppressor protein with catenins

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12 December 2020

The metalloproteinase matrilysin is a target of beta-catenin transactivation in intestinal tumors

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12 December 2020

Localization of the gene for familial adenomatous polyposis on chromosome 5.

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12 December 2020

Dimer formation by an N-terminal coiled coil in the APC protein

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12 December 2020

APC mutations occur early during colorectal tumorigenesis

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12 December 2020

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

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12 December 2020

Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

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12 December 2020

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.

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12 December 2020

The APC gene in colorectal cancer

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12 December 2020

Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.

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12 December 2020

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

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12 December 2020

Roles of Rho-family GTPases in cell polarisation and directional migration

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12 December 2020

Nuclear export of the APC tumour suppressor controls beta-catenin function in transcription

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12 December 2020

EB1, a protein which interacts with the APC tumour suppressor, is associated with the microtubule cytoskeleton throughout the cell cycle

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12 December 2020

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

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12 December 2020

In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis

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12 December 2020

The mammalian homolog of the Drosophila discs large tumor suppressor protein up-regulates expression of the ELR+ CXC chemokine Scyb5.

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12 December 2020

Wnt signaling and cancer

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12 December 2020

Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling

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12 December 2020

Expression of the APC tumor suppressor protein in oligodendroglia.

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12 December 2020

The APC gene product in normal and tumor cells

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12 December 2020

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

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12 December 2020

The subcellular destinations of APC proteins

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12 December 2020

A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein.

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12 December 2020

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

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12 December 2020

Identification and characterization of the familial adenomatous polyposis coli gene

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12 December 2020

DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95

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12 December 2020

Neuronal nicotinic synapse assembly requires the adenomatous polyposis coli tumor suppressor protein.

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12 December 2020

The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase

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12 December 2020

Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon

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12 December 2020

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12 December 2020

The gene for familial polyposis coli maps to the long arm of chromosome 5.

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12 December 2020

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly

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12 December 2020

Mutated APC and Asef are involved in the migration of colorectal tumour cells

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12 December 2020

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

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12 December 2020

Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein

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12 December 2020

Beta-catenin as oncogene: the smoking gun.

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12 December 2020

The many faces of the tumor suppressor gene APC

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12 December 2020

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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12 December 2020

Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells

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12 December 2020

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein.

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12 December 2020

The APC tumour suppressor has a nuclear export function.

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12 December 2020

The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions

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12 December 2020

Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells

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12 December 2020

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

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12 December 2020

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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12 December 2020

Examination of actin and microtubule dependent APC localisations in living mammalian cells

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12 December 2020

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

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12 December 2020

The adenomatous polyposis coli (APC) tumor suppressor

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12 December 2020

Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration

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12 December 2020

Association of the APC gene product with beta-catenin

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12 December 2020

The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells

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12 December 2020

NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC

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12 December 2020

Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia

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12 December 2020

Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene

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12 December 2020

Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells

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12 December 2020

EB/RP gene family encodes tubulin binding proteins

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12 December 2020

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12 December 2020

Wnt signaling: a common theme in animal development

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12 December 2020

Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein

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12 December 2020

Forced expression of the tumor suppressor adenomatosis polyposis coli protein induces disordered cell migration in the intestinal epithelium

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12 December 2020

High levels of expression of the tumor suppressor gene APC during development of the rat central nervous system.

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12 December 2020

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

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12 December 2020

Genotype-phenotype correlations at the adenomatous polyposis coli (APC) gene

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12 December 2020

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin

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12 December 2020

The tumor suppressor gene product APC is hyperphosphorylated during the M phase.

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12 December 2020

Biology of the adenomatous polyposis coli tumor suppressor

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12 December 2020

Subcellular localization of the APC protein: immunoelectron microscopic study of the association of the APC protein with catenin

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12 December 2020

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

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12 December 2020

Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons

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12 December 2020

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

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12 December 2020

The APC Tumor Suppressor Promotes Transcription-Independent Apoptosis In vitro

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12 December 2020

Subcellular localization of the tumor suppressor protein APC in developing cultured neurons

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12 December 2020

The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain

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12 December 2020

E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton

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12 December 2020

The APC protein binds to A/T rich DNA sequences

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12 December 2020

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

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12 December 2020

Subcellular targeting and cytoskeletal attachment of SAP97 to the epithelial lateral membrane.

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12 December 2020

Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene

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12 December 2020

Upregulation of the APC gene product during neuronal differentiation of rat pheochromocytoma PC12 cells.

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12 December 2020

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients

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12 December 2020

Rho-family GTPases in cadherin-mediated cell-cell adhesion

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12 December 2020

Microtubule-bundling activity of APC is stimulated by interaction with PSD-95

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12 December 2020

Familial adenomatous polyposis (FAP): frequency, penetrance, and mutation rate

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12 December 2020

Mutations of the APC (adenomatous polyposis coli) gene

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12 December 2020

Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein.

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12 December 2020

Localization of the adenomatous polyposis coli tumour suppressor protein in the mouse central nervous system.

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12 December 2020

Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization.

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12 December 2020

Regulation of armadillo by a Drosophila APC inhibits neuronal apoptosis during retinal development

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12 December 2020

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

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12 December 2020

Alternative splicing of the APC gene and its association with terminal differentiation.

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12 December 2020

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

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12 December 2020

Mal3, the fission yeast homologue of the human APC-interacting protein EB-1 is required for microtubule integrity and the maintenance of cell form

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12 December 2020

beta-catenin is a target for the ubiquitin-proteasome pathway

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12 December 2020

Neuronal localization of the Adenomatous polyposis coli tumor suppressor protein

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12 December 2020

The colorectal tumour suppressor APC is present in the NMDA-receptor-PSD-95 complex in the brain.

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12 December 2020

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

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12 December 2020

Expression of beta-catenin and full-length APC protein in normal and neoplastic colonic tissues.

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12 December 2020

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

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12 December 2020

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

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12 December 2020

Nuclear export of human beta-catenin can occur independent of CRM1 and the adenomatous polyposis coli tumor suppressor

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12 December 2020

The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin

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12 December 2020

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

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12 December 2020

Cancer, catenins, and cuticle pattern: a complex connection.

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12 December 2020

A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse

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12 December 2020

APC binds to the novel protein EB1

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12 December 2020

Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level

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12 December 2020

Regulation and function of the interaction between the APC tumour suppressor protein and EB1

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12 December 2020

Regulation of acetylcholine receptor clustering by the tumor suppressor APC

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12 December 2020

Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin

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12 December 2020

APC expression in normal human tissues

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12 December 2020

APC gene: database of germline and somatic mutations in human tumors and cell lines

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12 December 2020

Binding of the mammalian homolog of the Drosophila discs large tumor suppressor protein to the ribosome receptor

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12 December 2020

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

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12 December 2020

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

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12 December 2020

Regulation of caspase expression and apoptosis by adenomatous polyposis coli.

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12 December 2020

Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large

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12 December 2020

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

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12 December 2020

Identification of FAP locus genes from chromosome 5q21

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12 December 2020

APC and GSK-3beta are involved in mPar3 targeting to the nascent axon and establishment of neuronal polarity

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12 December 2020

Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

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12 December 2020

Association between wild type and mutant APC gene products.

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12 December 2020

The tumour suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase

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12 December 2020

Apc gene mutation is associated with a dominant-negative effect upon intestinal cell migration

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12 December 2020

Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

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12 December 2020

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

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12 December 2020

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

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12 December 2020

Novel protein isoforms of the APC tumor suppressor in neural tissue

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12 December 2020

A Drosophila APC tumour suppressor homologue functions in cellular adhesion

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12 December 2020

Adenomatous polyposis coli localization is both cell type and cell context dependent

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12 December 2020

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors

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12 December 2020

Microtubule behavior in the growth cones of living neurons during axon elongation

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12 December 2020

Signal transduction through beta-catenin and specification of cell fate during embryogenesis

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12 December 2020

Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

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12 December 2020

EphB/EphrinB receptors and Wnt signaling in colorectal cancer

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12 December 2020

Expression of beta-catenin and the adenomatous polyposis coli tumour suppressor protein in mouse neocortical cells in vitro.

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12 December 2020

CRM1- and Ran-independent nuclear export of beta-catenin.

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12 December 2020

Synapse-associated protein 97 selectively associates with a subset of AMPA receptors early in their biosynthetic pathway

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12 December 2020

10.1007/S00795-006-0352-5

Identifiers

DOI

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16 August 2017

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