mTOR signalling in human cancer (Q36919646)

17 August 2017

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title

mTOR signalling in human cancer (English)

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17 August 2017

Albanell J

1

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17 August 2017

Dalmases A

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2

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17 August 2017

Rovira A

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3

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17 August 2017

Rojo F

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4

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17 August 2017

1 August 2007

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Clinical and Translational Oncology

17 August 2017

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17 August 2017

9

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17 August 2017

8

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17 August 2017

484-493

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https://scigraph.springernature.com/pub.10.1007/s12094-007-0092-6

17 August 2017

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cites work

Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

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Crossref

https://api.crossref.org/works/10.1007%2FS12094-007-0092-6

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

21 January 2018

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12 December 2020

Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity

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12 December 2020

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

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12 December 2020

Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).

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12 December 2020

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

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12 December 2020

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

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12 December 2020

eIF4A: the godfather of the DEAD box helicases

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12 December 2020

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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12 December 2020

Use of proliferation signal inhibitors in the management of post-transplant malignancies--clinical guidance

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12 December 2020

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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12 December 2020

Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly

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12 December 2020

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

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12 December 2020

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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12 December 2020

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

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12 December 2020

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

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12 December 2020

Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer

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12 December 2020

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

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12 December 2020

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

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12 December 2020

Identification of insulin-induced sites of ribosomal protein S6 phosphorylation in Drosophila melanogaster

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12 December 2020

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways

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12 December 2020

Oncogenic mutations of PIK3CA in human cancers

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12 December 2020

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

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12 December 2020

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

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12 December 2020

Upstream and downstream of mTOR

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12 December 2020

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation

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12 December 2020

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12 December 2020

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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12 December 2020

Recent progress in the management of advanced renal cell carcinoma

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12 December 2020

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

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12 December 2020

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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12 December 2020

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

1 reference

12 December 2020

Aspects of mTOR biology and the use of mTOR inhibitors in non-Hodgkin's lymphoma

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12 December 2020

Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis

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12 December 2020

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

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12 December 2020

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

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12 December 2020

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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12 December 2020

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

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12 December 2020

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

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12 December 2020

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells

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12 December 2020

Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer

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12 December 2020

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

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12 December 2020

Rapamune (Sirolimus, rapamycin): an overview and mechanism of action.

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12 December 2020

The coordinate regulation of the p53 and mTOR pathways in cells

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12 December 2020

Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.

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12 December 2020

Identification of a conserved motif required for mTOR signaling

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12 December 2020

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway

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12 December 2020

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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12 December 2020

Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway

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12 December 2020

Molecular biology of renal cell carcinoma

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12 December 2020

The multifaceted role of mTOR in cellular stress responses

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12 December 2020

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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12 December 2020

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

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12 December 2020

Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.

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12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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12 December 2020

Met acts on Mdm2 via mTOR to signal cell survival during development.

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12 December 2020

Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.

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12 December 2020

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

1 reference

12 December 2020

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

1 reference

12 December 2020

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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12 December 2020

IRS-1: auditing the effectiveness of mTOR inhibitors

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12 December 2020

Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis

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12 December 2020

Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer

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12 December 2020

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

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12 December 2020

Impaired Fas response and autoimmunity in Pten+/- mice

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12 December 2020

Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells

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12 December 2020

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

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12 December 2020

TOR signaling in growth and metabolism

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12 December 2020

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

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12 December 2020

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

1 reference

12 December 2020

PKB/AKT: functional insights from genetic models

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12 December 2020

Targeting mTOR for cancer treatment.

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12 December 2020

Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth

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12 December 2020

The development of synaptophysin-like immunoreactivity in the lumbosacral enlargement of the spinal cord of the opossum Monodelphis domestica.

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12 December 2020

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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12 December 2020

Growing roles for the mTOR pathway

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12 December 2020

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

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12 December 2020

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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12 December 2020

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

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12 December 2020

Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer

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12 December 2020

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

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12 December 2020

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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12 December 2020

TOR, a central controller of cell growth

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12 December 2020

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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12 December 2020

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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12 December 2020

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

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12 December 2020

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

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12 December 2020

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

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12 December 2020

Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin

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12 December 2020

Activity of rapamycin (AY-22,989) against transplanted tumors

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12 December 2020

Present strategies in the treatment of metastatic renal cell carcinoma: an update on molecular targeting agents.

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12 December 2020

Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis

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12 December 2020

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

1 reference

12 December 2020

Differential kinetics of changes in the state of phosphorylation of ribosomal protein S6 and in the rate of protein synthesis in MPC 11 cells during tonicity shifts.

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12 December 2020

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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12 December 2020

Functional significance of S6K overexpression in meningioma progression

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12 December 2020

Rheb promotes cell growth as a component of the insulin/TOR signalling network

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12 December 2020

Constipation, polyps, or cancer? let PTEN predict your future

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12 December 2020

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

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12 December 2020

4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis

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12 December 2020

eIF4E--from translation to transformation

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12 December 2020

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

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12 December 2020

Akt/protein kinase B promotes organ growth in transgenic mice

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12 December 2020

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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12 December 2020

Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs

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12 December 2020

Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.

1 reference

12 December 2020

10.1007/S12094-007-0092-6

Identifiers

DOI

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17 August 2017

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