mTOR signalling in human cancer (Q36919646)

17 August 2017

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title

mTOR signalling in human cancer (English)

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17 August 2017

Albanell J

1

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17 August 2017

Dalmases A

series ordinal

2

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17 August 2017

Rovira A

series ordinal

3

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17 August 2017

Rojo F

series ordinal

4

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17 August 2017

publication date

1 August 2007

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Clinical and Translational Oncology

17 August 2017

published in

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17 August 2017

volume

9

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17 August 2017

issue

8

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17 August 2017

page(s)

484-493

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Rhebbing up mTOR: New Insights on TSC1 and TSC2, and the Pathogenesis of Tuberous Sclerosis

17 August 2017

cites work

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Crossref

https://api.crossref.org/works/10.1007%2FS12094-007-0092-6

Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities

21 January 2018

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12 December 2020

Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity

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12 December 2020

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines

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12 December 2020

Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).

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12 December 2020

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

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12 December 2020

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

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12 December 2020

eIF4A: the godfather of the DEAD box helicases

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12 December 2020

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

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12 December 2020

Use of proliferation signal inhibitors in the management of post-transplant malignancies--clinical guidance

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12 December 2020

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

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12 December 2020

Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly

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12 December 2020

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

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12 December 2020

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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12 December 2020

ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions

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12 December 2020

AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis

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12 December 2020

Rapamycin-induced endothelial cell death and tumor vessel thrombosis potentiate cytotoxic therapy against pancreatic cancer

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12 December 2020

Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue

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12 December 2020

Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt Activity.

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12 December 2020

Identification of insulin-induced sites of ribosomal protein S6 phosphorylation in Drosophila melanogaster

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12 December 2020

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways

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12 December 2020

Oncogenic mutations of PIK3CA in human cancers

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12 December 2020

mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events

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12 December 2020

The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.

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12 December 2020

Upstream and downstream of mTOR

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12 December 2020

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation

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12 December 2020

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12 December 2020

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

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12 December 2020

Recent progress in the management of advanced renal cell carcinoma

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12 December 2020

Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?

1 reference

12 December 2020

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

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12 December 2020

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI.

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12 December 2020

Aspects of mTOR biology and the use of mTOR inhibitors in non-Hodgkin's lymphoma

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12 December 2020

Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis

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12 December 2020

eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR

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12 December 2020

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

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12 December 2020

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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12 December 2020

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

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12 December 2020

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

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12 December 2020

Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells

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12 December 2020

Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer

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12 December 2020

Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA.

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12 December 2020

Rapamune (Sirolimus, rapamycin): an overview and mechanism of action.

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12 December 2020

The coordinate regulation of the p53 and mTOR pathways in cells

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12 December 2020

Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27.

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12 December 2020

Identification of a conserved motif required for mTOR signaling

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12 December 2020

Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway

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12 December 2020

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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12 December 2020

Interferon-gamma-induced dephosphorylation of STAT3 and apoptosis are dependent on the mTOR pathway

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12 December 2020

Molecular biology of renal cell carcinoma

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12 December 2020

The multifaceted role of mTOR in cellular stress responses

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12 December 2020

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

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12 December 2020

Positive regulation of the cAMP-responsive activator CREM by the p70 S6 kinase: an alternative route to mitogen-induced gene expression

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12 December 2020

Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB.

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12 December 2020

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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12 December 2020

Met acts on Mdm2 via mTOR to signal cell survival during development.

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12 December 2020

Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer.

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12 December 2020

The ATRs, ATMs, and TORs are giant HEAT repeat proteins.

1 reference

12 December 2020

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

1 reference

12 December 2020

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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12 December 2020

IRS-1: auditing the effectiveness of mTOR inhibitors

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12 December 2020

Not just for housekeeping: protein initiation and elongation factors in cell growth and tumorigenesis

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12 December 2020

Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer

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12 December 2020

The rapamycin-binding domain governs substrate selectivity by the mammalian target of rapamycin

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12 December 2020

Impaired Fas response and autoimmunity in Pten+/- mice

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12 December 2020

Rapamycin inhibits constitutive p70s6k phosphorylation, cell proliferation, and colony formation in small cell lung cancer cells

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12 December 2020

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

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12 December 2020

TOR signaling in growth and metabolism

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12 December 2020

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

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12 December 2020

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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12 December 2020

PKB/AKT: functional insights from genetic models

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12 December 2020

Targeting mTOR for cancer treatment.

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12 December 2020

Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth

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12 December 2020

The development of synaptophysin-like immunoreactivity in the lumbosacral enlargement of the spinal cord of the opossum Monodelphis domestica

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12 December 2020

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

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12 December 2020

Growing roles for the mTOR pathway

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12 December 2020

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

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12 December 2020

TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth

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12 December 2020

hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

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12 December 2020

Phosphorylated 4E binding protein 1: a hallmark of cell signaling that correlates with survival in ovarian cancer

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12 December 2020

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

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12 December 2020

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

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12 December 2020

TOR, a central controller of cell growth

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12 December 2020

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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12 December 2020

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

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12 December 2020

A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin

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12 December 2020

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

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12 December 2020

Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.

1 reference

12 December 2020

Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin

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12 December 2020

Activity of rapamycin (AY-22,989) against transplanted tumors

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12 December 2020

Present strategies in the treatment of metastatic renal cell carcinoma: an update on molecular targeting agents.

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12 December 2020

Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis

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12 December 2020

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

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12 December 2020

Differential kinetics of changes in the state of phosphorylation of ribosomal protein S6 and in the rate of protein synthesis in MPC 11 cells during tonicity shifts.

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12 December 2020

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

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12 December 2020

Functional significance of S6K overexpression in meningioma progression

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12 December 2020

Rheb promotes cell growth as a component of the insulin/TOR signalling network

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12 December 2020

Constipation, polyps, or cancer? let PTEN predict your future

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12 December 2020

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

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12 December 2020

4E-binding protein 1, a cell signaling hallmark in breast cancer that correlates with pathologic grade and prognosis

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12 December 2020

eIF4E--from translation to transformation

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12 December 2020

MAP kinases, phosphatidylinositol 3-kinase, and p70 S6 kinase mediate the mitogenic response of human endothelial cells to vascular endothelial growth factor

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12 December 2020

Akt/protein kinase B promotes organ growth in transgenic mice

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12 December 2020

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

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12 December 2020

Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs

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12 December 2020

Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53.

1 reference

12 December 2020

10.1007/S12094-007-0092-6

Identifiers

DOI

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17 August 2017

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