Drugs as CYP3A probes, inducers, and inhibitors (Q37023996)

17 August 2017

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title

Drugs as CYP3A probes, inducers, and inhibitors (English)

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17 August 2017

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Yi-Tong Liu

1

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17 August 2017

Hai-Ping Hao

2

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17 August 2017

Chang-Xiao Liu

3

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17 August 2017

Guang-Ji Wang

4

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17 August 2017

Hong-Guang Xie

5

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17 August 2017

language of work or name

English

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publication date

1 January 2007

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17 August 2017

Drug Metabolism Reviews

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17 August 2017

39

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17 August 2017

4

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17 August 2017

699-721

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Factors affecting cytochrome P-450 3A activity in cancer patients.

17 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

CYP3A4 activity in four different animal species liver microsomes using 7-benzyloxyquinoline and HPLC/spectrofluorometric determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Transporter-Enzyme Interactions: Implications for Predicting Drug-Drug Interactions from In Vitro Data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Cytochrome P450 3A and their regulation

21 January 2018

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https://api.crossref.org/works/10.1080%2F03602530701690374

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Methodologies to study the induction of rat hepatic and intestinal cytochrome P450 3A at the mRNA, protein, and catalytic activity level.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Effect of CYP3A5 polymorphism on tacrolimus metabolic clearance in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Erythromycin increases plasma concentrations of alpha-dihydroergocryptine in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Comparative CYP3A4 inhibitory effects of venlafaxine, fluoxetine, sertraline, and nefazodone in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: a comparison with SKF-525A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Pharmacokinetics of vincristine in cancer patients treated with nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Evidence for the validity of cortisol 6 beta-hydroxylation clearance as a new index for in vivo cytochrome P450 3A phenotyping in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Urinary 6?-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Age and gender effects on the pharmacokinetics and pharmacodynamics of triazolam, a cytochrome P450 3A substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Clinical pharmacokinetics of alprazolam. Therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Effects of dexamethasone on mRNA abundance of nuclear receptors and hepatic nuclear receptor target genes in neonatal calves.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Factors influencing midazolam hydroxylation activity in human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Evidence of significant contribution from CYP3A5 to hepatic drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Role of itraconazole metabolites in CYP3A4 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

The constitutive active/androstane receptor regulates phenytoin induction of Cyp2c29.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Limited contribution of CYP3A5 to the hepatic 6beta-hydroxylation of testosterone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Contribution of CYP3A5 to the in vitro hepatic clearance of tacrolimus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Drugs as P-glycoprotein substrates, inhibitors, and inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Differential drug-induced mRNA expression of human CYP3A4 compared to CYP3A5, CYP3A7 and CYP3A43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Gastrointestinal and systemic uptake of bismuth in mice after oral exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Genetic contribution to variable human CYP3A-mediated metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Measurement of hepatic and intestinal CYP3A4 and PGP activity by combined po + iv [14C]erythromycin breath and urine test

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Coadministration of lopinavir/ritonavir and phenytoin results in two-way drug interaction through cytochrome P-450 induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Interindividual variability in inhibition and induction of cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Expression and induction of CYP3As in human fetal hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Metabolism and elimination of quinine in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Use of a benzyloxy-substituted lactone cyclooxygenase-2 inhibitor as a selective fluorescent probe for CYP3A activity in primary cultured rat and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Can oral midazolam predict oral cyclosporine disposition?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

The human intestinal cytochrome P450 "pie".

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

MDR- and CYP3A4-mediated drug-herbal interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Effect of Cimetidine and Phenobarbital on metabolite kinetics of Omeprazole in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Strategies to overcome simultaneous P-glycoprotein mediated efflux and CYP3A4 mediated metabolism of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Summary of information on human CYP enzymes: human P450 metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Differential enantioselectivity and product-dependent activation and inhibition in metabolism of verapamil by human CYP3As

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Cytochrome P450 fluorometric substrates: identification of isoform-selective probes for rat CYP2D2 and human CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Nuclear receptors and drug disposition gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Induction of CYP3As in HepG2 cells by several drugs. Association between induction of CYP3A4 and expression of glucocorticoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro and in vivo assessment of herb drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Nuclear receptor expression in fetal and pediatric liver: correlation with CYP3A expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

St John's wort-associated drug interactions: short-term inhibition and long-term induction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Molecular basis of ethnic differences in drug disposition and response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Genetic variability in CYP3A5 and its possible consequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Induction of phase I, II and III drug metabolism/transport by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Inhibitory effects of verapamil and diltiazem on simvastatin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Inhibition of cytochromes P450 by antifungal imidazole derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Noninvasive tests of CYP3A enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

In vitro and in vivo correlation of the inhibitory effect of cyclosporin A on the transporter-mediated hepatic uptake of cerivastatin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530701690374

10.1080/03602530701690374

21 January 2018

Identifiers

DOI

1 reference

17 August 2017

1 reference