The DNA damage response pathways: at the crossroad of protein modifications (Q37034923)

17 August 2017

1 reference

title

The DNA damage response pathways: at the crossroad of protein modifications (English)

1 reference

17 August 2017

0 references

Michael S Y Huen

1

1 reference

PubMed ID

18087291

17 August 2017

Junjie Chen

series ordinal

2

1 reference

PubMed ID

18087291

17 August 2017

language of work or name

1 reference

1 January 2008

1 reference

17 August 2017

1 reference

17 August 2017

18

1 reference

17 August 2017

1

1 reference

17 August 2017

8-16

1 reference

https://scigraph.springernature.com/pub.10.1038/cr.2007.109

17 August 2017

0 references

cites work

Mechanisms of disease: DNA repair defects and neurological disease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

ATM gene and lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The BRCT Domain Is a Phospho-Protein Binding Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The FHA domain is a modular phosphopeptide recognition motif.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

CCDC98 targets BRCA1 to DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Proteasome function is required for DNA damage response and fanconi anemia pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Ubiquitin-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Role of ubiquitin- and Ubl-binding proteins in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Ubiquitinated proliferating cell nuclear antigen activates translesion DNA polymerases eta and REV1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

A ubiquitin-binding motif in the translesion DNA polymerase Rev1 mediates its essential functional interaction with ubiquitinated proliferating cell nuclear antigen in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The Saccharomyces cerevisiae rev6-1 mutation, which inhibits both the lesion bypass and the recombination mode of DNA damage tolerance, is an allele of POL30, encoding proliferating cell nuclear antigen.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Human SHPRH is a ubiquitin ligase for Mms2-Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

ATR couples FANCD2 monoubiquitination to the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

A novel ubiquitin ligase is deficient in Fanconi anemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Dedicated to the core: understanding the Fanconi anemia complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCA1-independent ubiquitination of FANCD2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

MDC1 is a mediator of the mammalian DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Post-translational modification of p53 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Modulation of p53 function by SET8-mediated methylation at lysine 382

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

Methylation-acetylation interplay activates p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

The MRN complex: coordinating and mediating the response to broken chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

SIRT1 regulates the function of the Nijmegen breakage syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

ATM gene alterations in childhood acute lymphoblastic leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

7 January 2021

DNA repair: The Nijmegen breakage syndrome protein

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

7 January 2021

FHA domains as phospho-threonine binding modules in cell signaling.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

7 January 2021

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

7 January 2021

UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1038%2FCR.2007.109

7 January 2021

Identifiers

DOI

10.1038/CR.2007.109

1 reference

17 August 2017

1 reference

PubMed ID

18087291