Functional role of Notch signaling in the developing and postnatal heart (Q37138197)

18 August 2017

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title

Functional role of Notch signaling in the developing and postnatal heart (English)

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18 August 2017

Mohamed Nemir

1

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PubMed ID

18410944

18 August 2017

Thierry Pedrazzini

series ordinal

2

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18 August 2017

10 March 2008

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Journal of Molecular and Cellular Cardiology

18 August 2017

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18 August 2017

45

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18 August 2017

4

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18 August 2017

495-504

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

18 August 2017

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Multiple functions of Notch signaling in self-renewing organs and cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling and inherited disease syndromes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

The role of Notch in tumorigenesis: oncogene or tumour suppressor?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Self-renewal and cancer of the gut: two sides of a coin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Control of cardiogenesis by the notch pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling in the developing cardiovascular system

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signalling: a simple pathway becomes complex

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Glycosylation regulates Notch signalling.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signalling regulates stem cell numbers in vitro and in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

The roles of receptor and ligand endocytosis in regulating Notch signaling

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling--constantly on the move

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Bare rudiments of notch signaling: how receptor levels are regulated

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch1 functions as a tumor suppressor in mouse skin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch controls proliferation and differentiation of stem cells in a dose-dependent manner.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Crossing paths with Notch in the hyper-network

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

HES and HERP families: multiple effectors of the Notch signaling pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling in stem cell systems

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Asymmetric self-renewal and commitment of satellite stem cells in muscle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch-mediated restoration of regenerative potential to aged muscle

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

The regulation of Notch signaling in muscle stem cell activation and postnatal myogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Making or breaking the heart: from lineage determination to morphogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Building the mammalian heart from two sources of myocardial cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Heart valve development: endothelial cell signaling and differentiation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Developmental patterning of the myocardium

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Cardiac chamber formation: development, genes, and evolution.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Biology of Isl1+ cardiac progenitor cells in development and disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch1 is essential for postimplantation development in mice.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

The expression of Jagged1 in the developing mammalian heart correlates with cardiovascular disease in Alagille syndrome

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Characterization of Notch receptor expression in the developing mammalian heart and liver.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling is essential for ventricular chamber development

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Dosage-sensitive requirement for mouse Dll4 in artery development

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

RBP-Jkappa-dependent notch signaling is dispensable for mouse early embryonic development.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling regulates left-right asymmetry determination by inducing Nodal expression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling in vascular development and physiology

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Monitoring Notch1 activity in development: evidence for a feedback regulatory loop

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch1b and neuregulin are required for specification of central cardiac conduction tissue.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch signaling plays a key role in cardiac cell differentiation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Mutations in NOTCH1 cause aortic valve disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

CHF1/Hey2 plays a pivotal role in left ventricular maturation through suppression of ectopic atrial gene expression

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Tetralogy of fallot and other congenital heart defects in Hey2 mutant mice

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch promotes neural lineage entry by pluripotent embryonic stem cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch Signaling Contributes to the Expression of Cardiac Markers in Human Circulating Progenitor Cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Jagged1 protein enhances the differentiation of mesenchymal stem cells into cardiomyocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Transcription factor CHF1/Hey2 suppresses cardiac hypertrophy through an inhibitory interaction with GATA4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Osteoblastic cells regulate the haematopoietic stem cell niche

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Identification of the haematopoietic stem cell niche and control of the niche size

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Adult cardiac stem cells are multipotent and support myocardial regeneration

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

FGF-dependent Notch signaling maintains the spinal cord stem zone

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Stem cell niches in the adult mouse heart

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

The spectrum of cardiovascular anomalies in CHF1/Hey2 deficient mice reveals roles in endocardial cushion, myocardial and vascular maturation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YJMCC.2008.02.273

10.1016/J.YJMCC.2008.02.273

7 January 2021

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18410944