Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin (Q37199784)

18 August 2017

Mutation of Gly721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin (English)

1 reference

18 August 2017

Marié van der Merwe

1

1 reference

PMCID

4995888

18 August 2017

Mary-Ann Bjornsti

series ordinal

2

1 reference

PMCID

4995888

18 August 2017

language of work or name

English

0 references

publication date

4 December 2007

1 reference

Journal of Biological Chemistry

18 August 2017

1 reference

18 August 2017

283

1 reference

18 August 2017

6

1 reference

18 August 2017

3305-3315

1 reference

Inhibition of topoisomerase I cleavage activity by thiol-reactive compounds: importance of vicinal cysteines 504 and 505

18 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Topoisomerase I inhibitors: camptothecins and beyond

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Structure, molecular mechanisms, and evolutionary relationships in DNA topoisomerases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Locking the DNA topoisomerase I protein clamp inhibits DNA rotation and induces cell lethality.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Single mutation in the linker domain confers protein flexibility and camptothecin resistance to human topoisomerase I.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Cancer therapeutics in yeast

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Cellular roles of dna topoisomerases: a molecular perspective

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Active site mutations in DNA topoisomerase I distinguish the cytotoxic activities of camptothecin and the indolocarbazole, rebeccamycin

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

DNA topoisomerases: structure, function, and mechanism

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Tumor cell death induced by topoisomerase-targeting drugs.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Topoisomerase I-mediated DNA damage

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

A functional linker in human topoisomerase I is required for maximum sensitivity to camptothecin in a DNA relaxation assay

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Induction of reversible complexes between eukaryotic DNA topoisomerase I and DNA-containing oxidative base damages. 7, 8-dihydro-8-oxoguanine and 5-hydroxycytosine

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

A model for the mechanism of human topoisomerase I

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Reconstitution of human topoisomerase I by fragment complementation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

The domain organization of human topoisomerase I

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

A novel mutation in DNA topoisomerase I of yeast causes DNA damage and RAD9-dependent cell cycle arrest.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

A novel suicide substrate for DNA topoisomerases and site-specific recombinases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Protein concerted motions in the DNA-human topoisomerase I complex.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I.

14 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

Mechanisms of camptothecin resistance by human topoisomerase I mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

Domain interactions affecting human DNA topoisomerase I catalysis and camptothecin sensitivity.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Mechanisms of camptothecin resistance in yeast DNA topoisomerase I mutants.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4995888

Residues within the N-terminal Domain of Human Topoisomerase I Play a Direct Role in Relaxation*

3 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

Antitumour drugs impede DNA uncoiling by topoisomerase I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705781200

Alterations in the catalytic activity of yeast DNA topoisomerase I result in cell cycle arrest and cell death

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18056711

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alterations in linker flexibility suppress DNA topoisomerase I mutant-induced cell lethality

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18056711

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Trapping of mammalian topoisomerase I and recombinations induced by damaged DNA containing nicks or gaps. Importance of DNA end phosphorylation and camptothecin effects

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18056711

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M705781200

1 reference

18 August 2017

1 reference

18 August 2017

1 reference

PMCID

4995888