Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets (Q37374651)

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scientific article published on January 2008

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English	Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets	scientific article published on January 2008

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scholarly article

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets (English)

1 reference

Europe PubMed Central

20 August 2017

3,4-dihydroxybenzoic acid

1 reference

ChEBI release 2020-05-28

1 reference

based on heuristic

inferred from title

Johanna Myllyharju

1

object named as

Johanna Myllyharju

1 reference

Europe PubMed Central

20 August 2017

language of work or name

0 references

publication date

1 January 2008

1 reference

Europe PubMed Central

20 August 2017

Annals of Medicine

1 reference

Europe PubMed Central

20 August 2017

40

1 reference

Europe PubMed Central

20 August 2017

402-417

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Europe PubMed Central

20 August 2017

6

1 reference

Europe PubMed Central

20 August 2017

Collagens, modifying enzymes and their mutations in humans, flies and worms

1 reference

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The collagen superfamily: from the extracellular matrix to the cell membrane

1 reference

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Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain

1 reference

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Variants in a novel epidermal collagen gene (COL29A1) are associated with atopic dermatitis

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21 January 2018

Prolyl 4-hydroxylases and their protein disulfide isomerase subunit

1 reference

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21 January 2018

Prolyl 4-hydroxylases, the key enzymes of collagen biosynthesis

1 reference

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21 January 2018

Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme

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21 January 2018

Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque.

1 reference

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21 January 2018

Cloning of the alpha subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties.

1 reference

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21 January 2018

The exoskeleton collagens in Caenorhabditis elegans are modified by prolyl 4-hydroxylases with unique combinations of subunits

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21 January 2018

Egg shell collagen formation in Caenorhabditis elegans involves a novel prolyl 4-hydroxylase expressed in spermatheca and embryos and possessing many unique properties

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Fork head and Sage maintain a uniform and patent salivary gland lumen through regulation of two downstream target genes, PH4alphaSG1 and PH4alphaSG2.

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21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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21 January 2018

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

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21 January 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

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21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

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21 January 2018

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

1 reference

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21 January 2018

Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of hypoxia-inducible factor-alpha/Sima

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21 January 2018

Oxygen sensing by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Signalling hypoxia by HIF hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Proline hydroxylation and gene expression

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Non-heme dioxygenases: cellular sensors and regulators jelly rolled into one?

1 reference

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21 January 2018

Hypoxia inducible factor prolyl 4-hydroxylase enzymes: center stage in the battle against hypoxia, metabolic compromise and oxidative stress

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Oxygen tension regulates the expression of a group of procollagen hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

RETRACTED: Lysyl oxidase is essential for hypoxia-induced metastasis

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Understanding hypoxia signalling in cells--a new therapeutic opportunity?

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF-1 and HIF-2: working alone or together in hypoxia?

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Acute postnatal ablation of Hif-2alpha results in anemia

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Assembly of human prolyl 4-hydroxylase and type III collagen in the yeast pichia pastoris: formation of a stable enzyme tetramer requires coexpression with collagen and assembly of a stable collagen requires coexpression with prolyl 4-hydroxylase

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hydroxylated human homotrimeric collagen I in Agrobacterium tumefaciens-mediated transient expression and in transgenic tobacco plant

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Production of human prolyl 4-hydroxylase in Escherichia coli

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

High-level production of human collagen prolyl 4-hydroxylase in Escherichia coli

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Characterization of human type III collagen expressed in a baculovirus system. Production of a protein with a stable triple helix requires coexpression with the two types of recombinant prolyl 4-hydroxylase subunit

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Expression of wild-type and modified proalpha chains of human type I procollagen in insect cells leads to the formation of stable [alpha1(I)]2alpha2(I) collagen heterotrimers and [alpha1(I)]3 homotrimers but not [alpha2(I)]3 homotrimers

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Production of recombinant human type I procollagen trimers using a four-gene expression system in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

High-level production of human type I collagen in the yeast Pichia pastoris

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Assembly of stable human type I and III collagen molecules from hydroxylated recombinant chains in the yeast Pichia pastoris. Effect of an engineered C-terminal oligomerization domain foldon

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The peptide-substrate-binding domain of human collagen prolyl 4-hydroxylases. Backbone assignments, secondary structure, and binding of proline-rich peptides

1 reference

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21 January 2018

The peptide-substrate-binding domain of collagen prolyl 4-hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues

1 reference

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21 January 2018

Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase. Identification of a previously unknown alternatively spliced exon and its expression in various tissues

1 reference

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21 January 2018

Collagens and collagen-related diseases

1 reference

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21 January 2018

Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels

1 reference

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21 January 2018

Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice

1 reference

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21 January 2018

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

An alternatively spliced transcript of the PHD3 gene retains prolyl hydroxylase activity.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Differential regulation of HIF-1 alpha prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Expression and actions of HIF prolyl-4-hydroxylase in the rat kidneys.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The von Hippel Lindau/hypoxia-inducible factor (HIF) pathway regulates the transcription of the HIF-proline hydroxylase genes in response to low oxygen

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

A family with erythrocytosis establishes a role for prolyl hydroxylase domain protein 2 in oxygen homeostasis

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Chlamydomonas reinhardtii has multiple prolyl 4-hydroxylases, one of which is essential for proper cell wall assembly.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The active site of an algal prolyl 4-hydroxylase has a large structural plasticity

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The HAG mechanism: a molecular rationale for the therapeutic application of iron chelators in human diseases involving the 2-oxoacid utilizing dioxygenases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Determination and comparison of specific activity of the HIF-prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Collagen prolyl 4-hydroxylase tetramers and dimers show identical decreases in Km values for peptide substrates with increasing chain length: mutation of one of the two catalytic sites in the tetramer inactivates the enzyme by more than half

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Many amino acid substitutions in a hypoxia-inducible transcription factor (HIF)-1alpha-like peptide cause only minor changes in its hydroxylation by the HIF prolyl 4-hydroxylases: substitution of 3,4-dehydroproline or azetidine-2-carboxylic acid for

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Oxygen and iron regulation of iron regulatory protein 2.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The novel WD-repeat protein Morg1 acts as a molecular scaffold for hypoxia-inducible factor prolyl hydroxylase 3 (PHD3)

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The HIF pathway as a therapeutic target

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hydroxylation of hypoxia-inducible transcription factors and chemical compounds targeting the HIF-alpha hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Cobalt inhibits the interaction between hypoxia-inducible factor-alpha and von Hippel-Lindau protein by direct binding to hypoxia-inducible factor-alpha

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Nitric oxide inhibits the synthesis of type-II collagen without altering Col2A1 mRNA abundance: prolyl hydroxylase as a possible target

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Nitric oxide impairs normoxic degradation of HIF-1alpha by inhibition of prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Nitric oxide modulates oxygen sensing by hypoxia-inducible factor 1-dependent induction of prolyl hydroxylase 2.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Reactive oxygen species and cellular oxygen sensing

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Design and synthesis of a series of novel pyrazolopyridines as HIF-1alpha prolyl hydroxylase inhibitors

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Therapeutic approaches to organ fibrosis

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin protect from retinal degeneration

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia and the HIF system in kidney disease

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia-induced stroke tolerance in the mouse is mediated by erythropoietin.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Translation of ischemic preconditioning to the patient: prolyl hydroxylase inhibition and hypoxia inducible factor-1 as novel targets for stroke therapy.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Novel strategies for stimulating erythropoiesis and potential new treatments for anaemia

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

New agents that stimulate erythropoiesis

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Regulation of angiogenesis by hypoxia: role of the HIF system

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Gene therapy progress and prospects: therapeutic angiogenesis for ischemic cardiovascular disease

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Activation of hypoxia-inducible factors in hyperoxia through prolyl 4-hydroxylase blockade in cells and explants of primate lung

1 reference

https://api.crossref.org/works/10.1080%2F07853890801986594

21 January 2018

Identifiers

10.1080/07853890801986594

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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