Serine kinases of insulin receptor substrate proteins (Q37403970)

20 August 2017

1 reference

title

Serine kinases of insulin receptor substrate proteins (English)

1 reference

20 August 2017

1 reference

Sigalit Boura-Halfon

1

1 reference

PubMed ID

19251043

20 August 2017

Yehiel Zick

series ordinal

2

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20 August 2017

1 January 2009

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20 August 2017

Vitamins and Hormones

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20 August 2017

80

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20 August 2017

313-349

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FAN, a novel WD-repeat protein, couples the p55 TNF-receptor to neutral sphingomyelinase

20 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Cross-talk between skeletal muscle and adipose tissue: a link with obesity?

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

IKK-beta links inflammation to obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells. Transfection studies suggest a role for PKC-zeta in glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PKC- Mediates Insulin Effects on Glucose Transport in Cultured Preadipocyte-Derived Human Adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The IGF-I receptor in cancer research

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Transforming growth factor-beta and insulin-like growth factor-I in relation to diabetes-induced impairment of wound healing

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Activation of protein kinase C zeta induces serine phosphorylation of VAMP2 in the GLUT4 compartment and increases glucose transport in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Altering the genome by homologous recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The renaissance of GSK3

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Signal transduction by the JNK group of MAP kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation and function by mitogen-activated protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Inflammation and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

SIK2 can be activated by deprivation of nutrition and it inhibits expression of lipogenic genes in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Cloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The pleckstrin homology (PH) domain-interacting protein couples the insulin receptor substrate 1 PH domain to insulin signaling pathways leading to mitogenesis and GLUT4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of Irs1 at SER-522 inhibits insulin signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PKCdelta-mediated IRS-1 Ser24 phosphorylation negatively regulates IRS-1 function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Defining the role of mTOR in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

AMPK and Raptor: matching cell growth to energy supply.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Common inhibitory serine sites phosphorylated by IRS-1 kinases, triggered by insulin and inducers of insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Time-dependent effects of fatty acids on skeletal muscle metabolism.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

A central role for JNK in obesity and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Complexity of the TOR signaling network

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Dysregulation of the TSC-mTOR pathway in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The IKK complex: an integrator of all signals that activate NF-kappaB?

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Role of insulin receptor substrate-1 and pp60 in the regulation of insulin-induced glucose transport and GLUT4 translocation in primary adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Mechanisms linking obesity to insulin resistance and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Tumor necrosis factor alpha-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells).

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Prevention of fat-induced insulin resistance by salicylate

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PKC-theta knockout mice are protected from fat-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute [...]

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The Mammalian target of rapamycin pathway regulates nutrient-sensitive glucose uptake in man

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Activation of IkappaB kinase beta by protein kinase C isoforms

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

mTOR pathway as a target in tissue hypertrophy.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Knockout of PKC alpha enhances insulin signaling through PI3K

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Recent advances in our understanding of insulin action and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Molecular and cellular aspects of the insulin-like growth factor I receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Serine 332 phosphorylation of insulin receptor substrate-1 by glycogen synthase kinase-3 attenuates insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase Czeta mediates insulin-induced glucose transport through actin remodeling in L6 muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Alterations of proteasome activities in skeletal muscle tissue of diabetic rats.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor substrate-1 (IRS-1) attenuates the interaction with the insulin receptor and the tyrosine phosphorylation of IRS-1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Jun N-terminal kinase mediates activation of skeletal muscle glycogen synthase by insulin in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin-induced stimulation of JNK and the PI 3-kinase/mTOR pathway leads to phosphorylation of serine 318 of IRS-1 in C2C12 myotubes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The IRS-1 signaling system

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Myosin motor Myo1c and its receptor NEMO/IKK-gamma promote TNF-alpha-induced serine307 phosphorylation of IRS-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Regulation of insulin receptor substrate 1 pleckstrin homology domain by protein kinase C: role of serine 24 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein modules and signalling networks

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphory

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

In vivo phosphorylation of insulin receptor substrate 1 at serine 789 by a novel serine kinase in insulin-resistant rodents

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and impairs its ability to activate phosphatidylinositol 3-kinase in response to insulin.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Myeloid C-type lectins in innate immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

FoxO transcription factors in the maintenance of cellular homeostasis during aging

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin signaling pathways in time and space.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Specific protein kinase C isoforms as transducers and modulators of insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Tyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Impaired insulin receptor phosphorylation in skeletal muscle membranes of db/db mice: the use of a novel skeletal muscle plasma membrane preparation to compare insulin binding and stimulation of receptor phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Inflammation and insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Wortmannin and LY294002 inhibit the insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

In vitro phosphorylation of insulin receptor substrate 1 by protein kinase C-zeta: functional analysis and identification of novel phosphorylation sites

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Role of IRS-2 in insulin and cytokine signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

One ring to rule a superfamily of E3 ubiquitin ligases

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

IRS proteins and the common path to diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

TOR signaling in growth and metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Expanding mTOR signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Negative regulation of cytokine signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Global Assessment of Regulation of Phosphorylation of Insulin Receptor Substrate-1 by Insulin In Vivo in Human Muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Regulation of insulin receptor function

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Insulin resistance: a phosphorylation-based uncoupling of insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Role of Ser/Thr kinases in the uncoupling of insulin signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0083-6729%2808%2900612-2

7 January 2021

10.1016/S0083-6729(08)00612-2

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19251043