RNA interference as an anticancer therapy: a patent perspective (Q37481329)

20 August 2017

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title

RNA interference as an anticancer therapy: a patent perspective (English)

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20 August 2017

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Derek M Dykxhoorn

1

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PubMed ID

19441927

20 August 2017

language of work or name

English

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publication date

1 April 2009

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Expert Opinion on Therapeutic Patents

20 August 2017

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20 August 2017

19

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20 August 2017

4

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20 August 2017

475-491

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The expanding universe of noncoding RNAs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

A mammalian microRNA expression atlas based on small RNA library sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

21 January 2018

Genomics of microRNA.

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https://api.crossref.org/works/10.1517%2F13543770902838008

MicroRNA genes are transcribed by RNA polymerase II

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

The nuclear RNase III Drosha initiates microRNA processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Processing of primary microRNAs by the Microprocessor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The human DiGeorge syndrome critical region gene 8 and Its D. melanogaster homolog are required for miRNA biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Nuclear export of microRNA precursors

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Role for a bidentate ribonuclease in the initiation step of RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

siRNA and miRNA: an insight into RISCs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Specificity of microRNA target selection in translational repression

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

siRNAs can function as miRNAs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

miRNA, siRNA, piRNA: Knowns of the unknown.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Prediction of mammalian microRNA targets

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

The widespread impact of mammalian MicroRNAs on mRNA repression and evolution

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

RNA interference and cancer: endogenous pathways and therapeutic approaches

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

A microRNA polycistron as a potential human oncogene

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

miR-15 and miR-16 induce apoptosis by targeting BCL2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

21 January 2018

An inside job for siRNAs

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Endogenous small interfering RNAs in animals

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Killing the messenger: short RNAs that silence gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Rational design and in vitro and in vivo delivery of Dicer substrate siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cancer genes and the pathways they control

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

21 January 2018

The Hallmarks of Cancer

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https://api.crossref.org/works/10.1517%2F13543770902838008

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Principles of tumor suppression

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Receptor tyrosine kinases: mechanisms of activation and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The protein tyrosine kinase family of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Oncogenic kinase signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Epidermal growth factor receptor dependence in human tumors: more than just expression?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cytokine signaling in 2002: new surprises in the Jak/Stat pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

PI3K pathway alterations in cancer: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

ERBB receptors and cancer: the complexity of targeted inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

MAP kinase signalling pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RAS oncogenes: the first 30 years.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Stable suppression of tumorigenicity by virus-mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Chromosomal abnormalities in cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Myc pathways provoking cell suicide and cancer

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Tumorigenesis and the angiogenic switch

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543770902838008

Angiogenesis: an organizing principle for drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Modulation of angiogenesis with siRNA inhibitors for novel therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The Met tyrosine kinase receptor in development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Mechanisms by which genes encoding growth factors and growth factor receptors contribute to malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Stable and complete overcoming of MDR1/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Modulation of the classical multidrug resistance (MDR) phenotype by RNA interference (RNAi).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Small interfering RNA-induced suppression of ERCC1 enhances sensitivity of human cancer cells to cisplatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Tumor regression in mice by delivery of Bcl-2 small interfering RNA with pegylated cationic liposomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The silent revolution: RNA interference as basic biology, research tool, and therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Modelling the molecular circuitry of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

A large-scale RNAi screen in human cells identifies new components of the p53 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

A genetic screen for candidate tumor suppressors identifies REST

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

A loss-of-function RNA interference screen for molecular targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Profiling essential genes in human mammary cells by multiplex RNAi screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cancer proliferation gene discovery through functional genomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The silent treatment: siRNAs as small molecule drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Knocking down disease with siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Inhibition of respiratory viruses by nasally administered siRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Progress towards in vivo use of siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Comprehensive analysis of the acute toxicities induced by systemic administration of cationic lipid:plasmid DNA complexes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cytotoxicity issues pertinent to lipoplex-mediated gene therapy in-vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Novel cationic cardiolipin analogue-based liposome for efficient DNA and small interfering RNA delivery in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

An endogenous small interfering RNA pathway in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RNAi-mediated gene silencing in non-human primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

DNA-polycation nanospheres as non-viral gene delivery vehicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cyclodextrin-modified polyethylenimine polymers for gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Chitosans for gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Efficient delivery of small interfering RNA to bone-metastatic tumors by using atelocollagen in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Transvascular delivery of small interfering RNA to the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Cell type-specific delivery of siRNAs with aptamer-siRNA chimeras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Strategies for silencing human disease using RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Therapeutic application of RNAi: is mRNA targeting finally ready for prime time?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RNAi and gene therapy: a mutual attraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Molecular engineering of viral gene delivery vehicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Adenovirus vectors for gene delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Adenovirus expressing shRNA to IGF-1R enhances the chemosensitivity of lung cancer cell lines by blocking IGF-1 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

VEGF-specific short hairpin RNA-expressing oncolytic adenovirus elicits potent inhibition of angiogenesis and tumor growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Inhibition of renal cancer cell growth in vitro and in vivo with oncolytic adenovirus armed short hairpin RNA targeting Ki-67 encoding mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Gene therapy using adeno-associated virus vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Use of adeno-associated viral vector for delivery of small interfering RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Risks and benefits of gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Effective inhibition of cell growth and invasion of melanoma by combined suppression of BRAF (V599E) and Skp2 with lentiviral RNAi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Optimization and functional effects of stable short hairpin RNA expression in primary human lymphocytes via lentiviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Expression of shRNA from a tissue-specific pol II promoter is an effective and safe RNAi therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Determinants of specific RNA interference-mediated silencing of human beta-globin alleles differing by a single nucleotide polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

siRNA-mediated off-target gene silencing triggered by a 7 nt complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Experimental validation of the importance of seed complement frequency to siRNA specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RNA interference and innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

Negotiating the RNAi patent thicket.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

The business of RNAi therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

RAF/RAS oncogenes and mismatch-repair status

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770902838008

10.1517/13543770902838008

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference

PubMed ID

19441927