IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1 (Q37488455)

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English	IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

20 August 2017

IκB kinase γ/nuclear factor-κB-essential modulator (IKKγ/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated KINASE (ROCK) to phosphorylate IKKβ in response to transforming growth factor (TGF)-β1 (English)

1 reference

Europe PubMed Central

20 August 2017

phosphorylation

0 references

author name string

Hee-Jun Kim

1

1 reference

Europe PubMed Central

20 August 2017

Jae-Gyu Kim

2

1 reference

Europe PubMed Central

20 August 2017

Mi-Young Moon

3

1 reference

Europe PubMed Central

20 August 2017

Seol-Hye Park

4

1 reference

Europe PubMed Central

20 August 2017

Jae-Bong Park

5

1 reference

Europe PubMed Central

20 August 2017

language of work or name

0 references

publication date

16 November 2013

1 reference

Europe PubMed Central

20 August 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

20 August 2017

289

1 reference

Europe PubMed Central

20 August 2017

3

1 reference

Europe PubMed Central

20 August 2017

1429-1440

1 reference

Europe PubMed Central

20 August 2017

Activated RhoA is a positive feedback regulator of the Lbc family of Rho guanine nucleotide exchange factor proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

NF-κB, the first quarter-century: remarkable progress and outstanding questions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Crystal structure of inhibitor of κB kinase β

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Protein-protein interactions involving IKKgamma (NEMO) that promote the activation of NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

TNF-like weak inducer of apoptosis (TWEAK) activates proinflammatory signaling pathways and gene expression through the activation of TGF-beta-activated kinase 1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Non-Smad pathways in TGF-beta signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Shared principles in NF-kappaB signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Transforming growth factor-beta regulation of immune responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

p120-catenin mediates inflammatory responses in the skin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Rho GTPases: biochemistry and biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Ubiquitin signalling in the NF-kappaB pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Signaling to NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

IkappaB kinases: key regulators of the NF-kappaB pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Transforming growth factor-beta-induced mobilization of actin cytoskeleton requires signaling by small GTPases Cdc42 and RhoA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

The activity of guanine exchange factor NET1 is essential for transforming growth factor-beta-mediated stress fiber formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Rho signals to cell growth and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Molecular basis for Rac2 regulation of phagocyte NADPH oxidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

23 August 2017

Small GTPase Rap1 regulates cell migration through regulation of small GTPase RhoA activity in response to transforming growth factor-β1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

6 September 2017

Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

6 September 2017

Transforming growth factor-beta1 regulates macrophage migration via RhoA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

6 September 2017

TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

6 September 2017

TGF-beta1 increases motility and alphavbeta3 integrin up-regulation via PI3K, Akt and NF-kappaB-dependent pathway in human chondrosarcoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

14 September 2017

Wnt-3a and Dvl induce neurite retraction by activating Rho-associated kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

14 September 2017

The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

14 September 2017

Rho as a regulator of the cytoskeleton.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

14 September 2017

Selective activation of small GTPase RhoA by tyrosine kinase Etk through its pleckstrin homology domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

28 September 2017

Constitutive association of TGF-beta-activated kinase 1 with the IkappaB kinase complex in the nucleus and cytoplasm of human neutrophils and its impact on downstream processes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

2 September 2018

Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

2 September 2018

Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3894326

2 September 2018

Determination of GTP loading on Rho

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.520130

21 January 2018

Rho proteins and the p38-MAPK pathway are important mediators for LPS-induced interleukin-8 expression in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of nucleotide release from Rho by the GDP dissociation stimulator protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IKKgamma /NEMO facilitates the recruitment of the IkappaB proteins into the IkappaB kinase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and characterization from bovine brain cytosol of two GTPase-activating proteins specific for smg p21, a GTP-binding protein having the same effector domain as c-ras p21s

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of nuclear factor-kB activation through RhoA/Rho-kinase pathway in LPS-induced IL-8 production in human cervical stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of the Interaction of Translation Factor SelB fromEscherichia coliwith Guanosine Nucleotides and Selenocysteine Insertion Sequence RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/24240172

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M113.520130

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

1 reference

Europe PubMed Central

20 August 2017

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