Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation. (Q37513993)

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English	Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.	scientific article

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27 March 2020

Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation (English)

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Michael Lazarou

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Thanh Ngoc Nguyen

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Benjamin Scott Padman

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Joanne Usher

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Journal of Cell Biology

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Syntaxin-17 delivers PINK1/parkin-dependent mitochondrial vesicles to the endolysosomal system.

1 reference

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Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

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Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation

1 reference

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Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy

1 reference

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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

1 reference

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

1 reference

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GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion

1 reference

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ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

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PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins

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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

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Ubiquitin is phosphorylated by PINK1 to activate parkin

1 reference

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PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

1 reference

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23 August 2017

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

1 reference

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Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

1 reference

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Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.

1 reference

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Genome engineering using the CRISPR-Cas9 system

1 reference

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The LIR motif - crucial for selective autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

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Autophagosomes form at ER-mitochondria contact sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

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The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

1 reference

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LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

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Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

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LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

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Network organization of the human autophagy system

1 reference

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LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

1 reference

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

1 reference

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Nix is a selective autophagy receptor for mitochondrial clearance

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A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure

1 reference

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

1 reference

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Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion

1 reference

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p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

1 reference

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Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice

1 reference

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1 reference

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A ubiquitin-like system mediates protein lipidation

1 reference

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23 August 2017

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1 reference

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A protein conjugation system essential for autophagy

1 reference

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23 August 2017

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

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23 August 2017

Autophagosome closure requires membrane scission

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Cargo recognition and trafficking in selective autophagy

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6 September 2017

Cargo binding to Atg19 unmasks additional Atg8 binding sites to mediate membrane-cargo apposition during selective autophagy.

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6 September 2017

The autophagosome: origins unknown, biogenesis complex

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6 September 2017

A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery

1 reference

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6 September 2017

Escape of intracellular Shigella from autophagy

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1 reference

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1 reference

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25 June 2018

ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs

1 reference

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25 June 2018

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1 reference

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25 June 2018

The ATG conjugation systems are important for degradation of the inner autophagosomal membrane.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

2 September 2018

The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

2 September 2018

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5166504

2 September 2018

Identifiers

10.1083/JCB.201607039

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27 March 2020

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Europe PubMed Central

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27 March 2020

1 reference

Europe PubMed Central

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27 March 2020

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