Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. (Q37524180)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24401270%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

title

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia (English)

1 reference

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4 March 2020

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1

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Richard W Groen

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4 March 2020

Alex Kentsis

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4 March 2020

Francoise Pflumio

10

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4 March 2020

Benjamin Uzan

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4 March 2020

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Sandrine Poglio

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Frederic Baleydier

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4 March 2020

author name string

Li Pan

2

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4 March 2020

Jason Marineau

6

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4 March 2020

Ruta Grebliunaite

7

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4 March 2020

Elena Kozakewich

8

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4 March 2020

Casie Reed

9

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4 March 2020

Paul Clemons

13

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Lynn VerPlank

14

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Frank An

15

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4 March 2020

Jason Burbank

16

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4 March 2020

Stephanie Norton

17

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4 March 2020

Nicola Tolliday

18

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Hanno Steen

19

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4 March 2020

Andrew P Weng

20

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4 March 2020

Huipin Yuan

21

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4 March 2020

James E Bradner

22

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4 March 2020

Constantine Mitsiades

23

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4 March 2020

A Thomas Look

24

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4 March 2020

Jon C Aster

25

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language of work or name

English

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publication date

9 January 2014

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Journal of Clinical Investigation

4 March 2020

published in

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4 March 2020

volume

124

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4 March 2020

page(s)

644-655

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4 March 2020

issue

2

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Defined, serum-free conditions for in vitro culture of primary human T-ALL blasts

4 March 2020

cites work

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Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells

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Chemical structure of phenothiazines and their biological activity

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

23 August 2017

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Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

23 August 2017

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23 August 2017

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Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

23 August 2017

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Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

23 August 2017

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Identification of PP2A complexes and pathways involved in cell transformation

23 August 2017

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Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

23 August 2017

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FTY720 shows promising in vitro and in vivo preclinical activity by downmodulating Cyclin D1 and phospho-Akt in mantle cell lymphoma

23 August 2017

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Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents

23 August 2017

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Genome-wide RNA-mediated interference screen identifies miR-19 targets in Notch-induced T-cell acute lymphoblastic leukaemia

23 August 2017

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Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

23 August 2017

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Serine/threonine phosphatases: mechanism through structure

23 August 2017

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Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study

23 August 2017

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T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993)

23 August 2017

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Role of dopamine in the physiology of T-cells and dendritic cells

23 August 2017

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High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

23 August 2017

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The canonical Notch signaling pathway: unfolding the activation mechanism

23 August 2017

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CSL-MAML-dependent Notch1 signaling controls T lineage-specific IL-7R{alpha} gene expression in early human thymopoiesis and leukemia

23 August 2017

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From promiscuity to precision: protein phosphatases get a makeover

23 August 2017

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Identifying the proteins to which small-molecule probes and drugs bind in cells

23 August 2017

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Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

23 August 2017

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Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

23 August 2017

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Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas

23 August 2017

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia

23 August 2017

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23 August 2017

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

23 August 2017

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FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

23 August 2017

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FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

23 August 2017

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CIP2A inhibits PP2A in human malignancies

23 August 2017

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

23 August 2017

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

23 August 2017

1 reference

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

23 August 2017

1 reference

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

23 August 2017

1 reference

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Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth.

23 August 2017

1 reference

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Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia.

23 August 2017

1 reference

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Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

23 August 2017

1 reference

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Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: clinical relevance and possible application for brain-derived tumors.

23 August 2017

1 reference

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Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

23 August 2017

1 reference

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

23 August 2017

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Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

23 August 2017

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23 August 2017

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Drug synergism: its detection and applications

23 August 2017

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Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation

23 August 2017

1 reference

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Reversible tumorigenesis by MYC in hematopoietic lineages

23 August 2017

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nacre encodes a zebrafish microphthalmia-related protein that regulates neural-crest-derived pigment cell fate

23 August 2017

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Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency

23 August 2017

1 reference

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Targeting nonclassical oncogenes for therapy in T-ALL.

6 September 2017

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Notch in T-ALL: new players in a complex disease.

6 September 2017

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A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells.

6 September 2017

1 reference

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NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

14 September 2017

1 reference

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Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia

14 September 2017

1 reference

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c-Myc substitutes for Notch1-CBF1 functions in cooperative transformation with papillomavirus oncogenes

14 September 2017

1 reference

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

14 September 2017

1 reference

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Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia

14 September 2017

1 reference

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Childhood T-Cell Acute Lymphoblastic Leukemia: The Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium Experience

14 September 2017

1 reference

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Dopamine receptor blockade and the neuroleptics, a crystallographic study

14 September 2017

1 reference

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Different susceptibility of lung cell lines to inhibitors of tumor promotion and inducers of differentiation

14 September 2017

1 reference

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PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation.

25 June 2018

1 reference

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A new genetic lesion in B-CLL: a NOTCH1 PEST domain mutation.

2 September 2018

1 reference

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Potential inhibition of PDK1/Akt signaling by phenothiazines suppresses cancer cell proliferation and survival

2 September 2018

1 reference

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Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation

2 September 2018

1 reference

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Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904599

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904599

Myc-induced T cell leukemia in transgenic zebrafish.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904599

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3904599

3 December 2018

Identifiers

DOI

10.1172/JCI65093

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24401270%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24401270%20AND%20SRC:MED&resulttype=core&format=json

4 March 2020

1 reference