Ras signaling and therapies (Q37548931)

21 August 2017

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title

Ras signaling and therapies (English)

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21 August 2017

Jesse Lyons

2

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author name string

Amy Young

1

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21 August 2017

Abigail L Miller

3

1 reference

21 August 2017

Vernon T Phan

4

1 reference

21 August 2017

Irma Rangel Alarcón

5

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21 August 2017

Frank McCormick

6

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21 August 2017

language of work or name

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1 January 2009

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Advances in Cancer Research

21 August 2017

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21 August 2017

102

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21 August 2017

1-17

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Phase II study of sorafenib in patients with advanced hepatocellular carcinoma

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-like phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

The VASP-Spred-Sprouty domain puzzle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Getting a first clue about SPRED functions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Clinical and molecular aspects of RAS related disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

MAP kinase signalling pathways in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

New insight into BRAF mutations in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Targeting RAS signalling pathways in cancer therapy

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https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Targeting RAS and PI3K in lung cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Eph receptors and ephrin signaling pathways: a role in bone homeostasis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Selective PDZ protein-dependent stimulation of phosphatidylinositol 3-kinase by the adenovirus E4-ORF1 oncoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Guilty as charged: B-RAF is a human oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

PI3K/PTEN signaling in tumorigenesis and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

TORC1 is essential for NF1-associated malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

The NF1 tumor suppressor critically regulates TSC2 and mTOR.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Modulation of signalling by Sprouty: a developing story

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Spatial regulation of EGFR signaling by Sprouty2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Dephosphorylation of Ser-259 regulates Raf-1 membrane association

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Mechanisms and functions of Eph and ephrin signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Sprouty and cancer: the first terms report.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

A conditional feedback loop regulates Ras activity through EphA2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

1 reference

7 January 2021

EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Eph receptor signalling casts a wide net on cell behaviour

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Ras oncogenes and their downstream targets

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Ras activation of phosphatidylinositol 3-kinase and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Phosphatidylinositol 3' kinase: one of the effectors of Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Phosphatidylinositol-3-OH kinase as a direct target of Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Deregulated Ras signaling in developmental disorders: new tricks for an old dog.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Hyperactive Ras in developmental disorders and cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Germline KRAS mutations cause Noonan syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

The role of ephrins and Eph receptors in cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Small GTP-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Noonan, Costello and cardio-facio-cutaneous syndromes: dysregulation of the Ras-MAPK pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Spred is a Sprouty-related suppressor of Ras signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

The RAF proteins take centre stage

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

PI3K pathway alterations in cancer: variations on a theme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

Class I PI3K in oncogenic cellular transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2809%2902001-6

7 January 2021

10.1016/S0065-230X(09)02001-6

Identifiers

DOI

1 reference

21 August 2017

1 reference