Therapeutic prospect of Syk inhibitors (Q37577893)

21 August 2017

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title

Therapeutic prospect of Syk inhibitors (English)

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21 August 2017

Andrea Calderan

3

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ORCID Public Data File 2021

author name string

Paolo Ruzza

series ordinal

1

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21 August 2017

Barbara Biondi

series ordinal

2

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21 August 2017

language of work or name

English

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publication date

1 October 2009

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Expert Opinion on Therapeutic Patents

21 August 2017

published in

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21 August 2017

volume

19

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21 August 2017

issue

10

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21 August 2017

page(s)

1361-1376

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

21 August 2017

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Kinomics: characterizing the therapeutically validated kinase space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Structure and function of Syk protein-tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

3D structure of Syk kinase determined by single-particle electron microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Conformational rearrangements upon Syk auto-phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Src protein-tyrosine kinase structure and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Structural basis for the inhibition of tyrosine kinase activity of ZAP-70

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Molecular mechanism of the Syk activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Proximal protein tyrosine kinases in immunoreceptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

21 January 2018

The many faces of ITAMs.

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Tyrosine kinase inhibitors: a new approach for asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Targeting Syk as a treatment for allergic and autoimmune disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Src and Syk kinases: key regulators of phagocytic cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Autoantibody-mediated demyelination depends on complement activation but not activatory Fc-receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Syk-dependent mTOR activation in follicular lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Constitutive kinase activation of the TEL-Syk fusion gene in myelodysplastic syndrome with t(9;12)(q22;p12).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Spleen tyrosine kinase functions as a tumor suppressor in melanoma cells by inducing senescence-like growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Tyrphostins and other tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Sequence and structural analysis of kinase ATP pocket residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Identification of the Syk kinase inhibitor R112 by a human mast cell screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Treatment of rheumatoid arthritis with a Syk kinase inhibitor: a twelve-week, randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

The orally available spleen tyrosine kinase inhibitor 2-[7-(3,4-dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino]nicotinamide dihydrochloride (BAY 61-3606) blocks antigen-induced airway inflammation in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Steady state kinetics of spleen tyrosine kinase investigated by a real time fluorescence assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

A novel Syk family kinase inhibitor: design, synthesis, and structure-activity relationship of 1,2,4-triazolo[4,3-c]pyrimidine and 1,2,4-triazolo[1,5-c]pyrimidine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Potent small molecule inhibitors of spleen tyrosine kinase (Syk).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Discovery and SAR of novel 4-thiazolyl-2-phenylaminopyrimidines as potent inhibitors of spleen tyrosine kinase (SYK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Piceatannol is an effective inhibitor of IgE-mediated secretion from human basophils but is neither selective for this receptor nor acts on syk kinase at concentrations where mediator release inhibition occurs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Inhibition of allergic inflammation in the airways using aerosolized antisense to Syk kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Molecular mechanisms of action of antisense drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Progress in antisense technology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Direct comparison of the specificity of gene silencing using antisense oligonucleotides and RNAi.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Antisense DNAs as multisite genomic modulators identified by DNA microarray

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Inhibition of high affinity basic fibroblast growth factor binding by oligonucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Evaluating the specificity of antisense oligonucleotide conjugates. A DNA array analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Gene silencing in mammals by small interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Activation of the interferon system by short-interfering RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Induction of the interferon response by siRNA is cell type- and duplex length-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Specific interference with gene function by double-stranded RNA in early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

RNase H-independent antisense activity of oligonucleotide N3 '--> P5 ' phosphoramidates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

The interaction of intercalators and groove-binding agents with DNA triple-helical structures: the influence of ligand structure, DNA backbone modifications and sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

31P NMR spectroscopy in oligonucleotide research and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Phagocytosis of Antibody-Coated Platelets by Human Granulocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Flow cytometric monocyte phagocytic assay for predicting platelet transfusion outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Anti-HPA-1a-mediated platelet phagocytosis by monocytes in vitro and its inhibition by Fc gamma receptor (FcgammaR) reactive reagents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

Points of control in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903207039

10.1517/13543770903207039

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference