Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors (Q37622077)

21 August 2017

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title

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors (English)

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21 August 2017

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Pamela Nicholson

1

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Oliver Mühlemann

series ordinal

6

object named as

Oliver Mühlemann

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21 August 2017

2

Hasmik Yepiskoposyan

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21 August 2017

Stefanie Metze

3

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21 August 2017

Rodolfo Zamudio Orozco

series ordinal

4

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21 August 2017

Nicole Kleinschmidt

series ordinal

5

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21 August 2017

publication date

27 October 2009

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Cellular and Molecular Life Sciences

21 August 2017

published in

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21 August 2017

volume

67

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21 August 2017

issue

5

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21 August 2017

page(s)

677-700

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Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

21 August 2017

cites work

1 reference

12 December 2020

DNA-activated protein kinase functions in a newly observed S phase checkpoint that links histone mRNA abundance with DNA replication.

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12 December 2020

An alternative branch of the nonsense-mediated decay pathway

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12 December 2020

P bodies: at the crossroads of post-transcriptional pathways

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12 December 2020

Interaction of translation factor SELB with the formate dehydrogenase H selenopolypeptide mRNA.

1 reference

12 December 2020

Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges

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12 December 2020

P-body formation is a consequence, not the cause, of RNA-mediated gene silencing

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12 December 2020

Genome-wide suppression of aberrant mRNA-like noncoding RNAs by NMD in Arabidopsis

1 reference

12 December 2020

Long 3'-UTRs target wild-type mRNAs for nonsense-mediated mRNA decay in Saccharomyces cerevisiae.

1 reference

12 December 2020

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

1 reference

12 December 2020

The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons

1 reference

12 December 2020

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

1 reference

12 December 2020

Mammalian orthologues of a yeast regulator of nonsense transcript stability

1 reference

12 December 2020

Gene products that promote mRNA turnover in Saccharomyces cerevisiae

1 reference

12 December 2020

The beginning of the end

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12 December 2020

Pharmacologic therapy for stop mutations: how much CFTR activity is enough?

1 reference

12 December 2020

At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

1 reference

12 December 2020

A protective role for the human SMG-1 kinase against tumor necrosis factor-alpha-induced apoptosis

1 reference

12 December 2020

The human RNA surveillance factor UPF1 is required for S phase progression and genome stability

1 reference

12 December 2020

Computational modeling and experimental analysis of nonsense-mediated decay in yeast

1 reference

12 December 2020

Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast

1 reference

12 December 2020

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway

1 reference

12 December 2020

Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection

1 reference

12 December 2020

A human sequence homologue of Staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum

1 reference

12 December 2020

smg-7 is required for mRNA surveillance in Caenorhabditis elegans.

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12 December 2020

Functional conservation of the telomerase protein Est1p in humans

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12 December 2020

The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex

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12 December 2020

Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance

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12 December 2020

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

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12 December 2020

SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

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12 December 2020

Interaction of Staufen1 with the 5' end of mRNA facilitates translation of these RNAs

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12 December 2020

DNA damage induces downregulation of histone gene expression through the G1 checkpoint pathway

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12 December 2020

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2

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12 December 2020

Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

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12 December 2020

Nonsense mutations in the human beta-globin gene lead to unexpected levels of cytoplasmic mRNA accumulation

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12 December 2020

Early nonsense: mRNA decay solves a translational problem

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12 December 2020

Disassembly of exon junction complexes by PYM

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12 December 2020

The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae

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12 December 2020

Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner

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12 December 2020

Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis

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12 December 2020

A recoding element that stimulates decoding of UGA codons by Sec tRNA[Ser]Sec

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12 December 2020

Four novel FBN1 mutations: significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome

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12 December 2020

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

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12 December 2020

Nonsense-mediated decay does not occur within the yeast nucleus

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12 December 2020

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

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12 December 2020

Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.

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12 December 2020

Regulated degradation of replication-dependent histone mRNAs requires both ATR and Upf1

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12 December 2020

Arabidopsis UPF1 RNA helicase for nonsense-mediated mRNA decay is involved in seed size control and is essential for growth

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12 December 2020

Messenger RNA turnover in eukaryotes: pathways and enzymes

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12 December 2020

The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein

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12 December 2020

Interaction between Nmd2p and Upf1p is required for activity but not for dominant-negative inhibition of the nonsense-mediated mRNA decay pathway in yeast

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12 December 2020

Aberrant mRNA transcripts and the nonsense-mediated decay proteins UPF2 and UPF3 are enriched in the Arabidopsis nucleolus.

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12 December 2020

Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay.

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12 December 2020

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival

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12 December 2020

The double life of UPF1 in RNA and DNA stability pathways

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12 December 2020

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential

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12 December 2020

Both introns and long 3'-UTRs operate as cis-acting elements to trigger nonsense-mediated decay in plants

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12 December 2020

hSMG-1 and ATM sequentially and independently regulate the G1 checkpoint during oxidative stress

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12 December 2020

A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

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12 December 2020

The meaning of nonsense

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12 December 2020

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

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12 December 2020

A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes

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12 December 2020

Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

1 reference

12 December 2020

UGA codon position affects the efficiency of selenocysteine incorporation into glutathione peroxidase-1

1 reference

12 December 2020

Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles

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12 December 2020

A pilot study of the effect of gentamicin on nasal potential difference measurements in cystic fibrosis patients carrying stop mutations

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12 December 2020

A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

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12 December 2020

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

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12 December 2020

A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

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12 December 2020

Estimating rates of alternative splicing in mammals and invertebrates

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12 December 2020

Interference of nonsense mutations with eukaryotic messenger RNA stability

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12 December 2020

The double-stranded RNA-binding protein Staufen is incorporated in human immunodeficiency virus type 1: evidence for a role in genomic RNA encapsidation

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12 December 2020

The control of mRNA decapping and P-body formation.

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12 December 2020

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

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12 December 2020

TPR proteins: the versatile helix

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12 December 2020

A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

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12 December 2020

Binary specification of nonsense codons by splicing and cytoplasmic translation

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12 December 2020

Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3

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12 December 2020

Nonsense surveillance in lymphocytes?

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12 December 2020

The telomeric transcriptome and SMG proteins at the crossroads.

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12 December 2020

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail

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12 December 2020

CBP80 promotes interaction of Upf1 with Upf2 during nonsense-mediated mRNA decay in mammalian cells.

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12 December 2020

Evidence that phosphorylation of human Upfl protein varies with intracellular location and is mediated by a wortmannin-sensitive and rapamycin-sensitive PI 3-kinase-related kinase signaling pathway

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12 December 2020

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

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12 December 2020

The mammalian nonsense-mediated mRNA decay pathway: to decay or not to decay! Which players make the decision?

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12 December 2020

The Rat1p 5′ to 3′ Exonuclease Degrades Telomeric Repeat-Containing RNA and Promotes Telomere Elongation in Saccharomyces cerevisiae

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12 December 2020

Recognition and elimination of nonsense mRNA.

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12 December 2020

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

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12 December 2020

The DNA damage response: putting checkpoints in perspective

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12 December 2020

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

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12 December 2020

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

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12 December 2020

Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex

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12 December 2020

Nonsense-mediated mRNA decay (NMD) mechanisms

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12 December 2020

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G

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12 December 2020

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

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12 December 2020

The multiple lives of NMD factors: balancing roles in gene and genome regulation

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12 December 2020

A novel protein domain induces high affinity selenocysteine insertion sequence binding and elongation factor recruitment

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12 December 2020

The enzymes and control of eukaryotic mRNA turnover

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12 December 2020

Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay

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12 December 2020

Telomere length regulation and telomeric chromatin require the nonsense-mediated mRNA decay pathway

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12 December 2020

Premature translational termination triggers mRNA decapping

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12 December 2020

SMD and NMD are competitive pathways that contribute to myogenesis: effects on PAX3 and myogenin mRNAs

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12 December 2020

Post-transcriptional control of animal histone gene expression--not so different after all...

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12 December 2020

Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay

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12 December 2020

SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.

1 reference

12 December 2020

Five Percent of Normal Cystic Fibrosis Transmembrane Conductance Regulator mRNA Ameliorates the Severity of Pulmonary Disease in Cystic Fibrosis

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12 December 2020

Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends

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12 December 2020

Premature termination codons enhance mRNA decapping in human cells.

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12 December 2020

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

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12 December 2020

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

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12 December 2020

Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression

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12 December 2020

Processing bodies are not required for mammalian nonsense-mediated mRNA decay

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12 December 2020

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

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12 December 2020

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

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12 December 2020

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

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12 December 2020

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements

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12 December 2020

Long mutant dystrophins and variable phenotypes: evasion of nonsense-mediated decay?

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12 December 2020

Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

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12 December 2020

Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

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12 December 2020

Alternative splicing resulting in nonsense-mediated mRNA decay: what is the meaning of nonsense?

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12 December 2020

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

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12 December 2020

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12 December 2020

Structural and functional insights into the human Upf1 helicase core

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12 December 2020

The regulation of histone synthesis in the cell cycle

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12 December 2020

Truncated WT1 mutants alter the subnuclear localization of the wild-type protein

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12 December 2020

Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

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12 December 2020

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

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12 December 2020

Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease

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12 December 2020

Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression

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12 December 2020

Metazoan replication-dependent histone mRNAs: a distinct set of RNA polymerase II transcripts

1 reference

12 December 2020

Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: a mechanism for the phenotype of dominant beta-thalassemia

1 reference

12 December 2020

A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans

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12 December 2020

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells

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12 December 2020

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

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12 December 2020

Looking at mRNA decay pathways through the window of molecular evolution

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12 December 2020

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

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12 December 2020

An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation

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12 December 2020

Genotype-phenotype correlation in cystic fibrosis: the role of modifier genes.

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12 December 2020

Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

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12 December 2020

Translation termination is involved in histone mRNA degradation when DNA replication is inhibited

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12 December 2020

Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.

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12 December 2020

The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells

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12 December 2020

Antibiotics show promise as therapy for genetic disorders

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12 December 2020

Infrequent translation of a nonsense codon is sufficient to decrease mRNA level

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12 December 2020

Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover

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12 December 2020

Upf1p, Nmd2p, and Upf3p are interacting components of the yeast nonsense-mediated mRNA decay pathway

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12 December 2020

Size matters: a view of selenocysteine incorporation from the ribosome

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12 December 2020

Unstable β-globin mRNA in mRNA-deficient β0 thalassemia

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12 December 2020

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

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12 December 2020

Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues

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12 December 2020

Frameshift suppression Saccharomyces cerevisiae. II. Genetic properties of group II suppressors.

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12 December 2020

Inter-kingdom conservation of mechanism of nonsense-mediated mRNA decay

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12 December 2020

Yeast Upf proteins required for RNA surveillance affect global expression of the yeast transcriptome

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12 December 2020

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

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12 December 2020

A UPF3-mediated regulatory switch that maintains RNA surveillance

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12 December 2020

Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells

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12 December 2020

WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

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12 December 2020

Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution

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12 December 2020

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

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12 December 2020

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay

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12 December 2020

Beginning to understand the end of the chromosome

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12 December 2020

Mammalian staufen is a double-stranded-RNA- and tubulin-binding protein which localizes to the rough endoplasmic reticulum

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12 December 2020

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay

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12 December 2020

Y14 and hUpf3b form an NMD-activating complex

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12 December 2020

Translation initiation factor eIF4G mediates in vitro poly(A) tail-dependent translation

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12 December 2020

Nonsense-mediated mRNA decay: target genes and functional diversification of effectors

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12 December 2020

Inhibition of nonsense-mediated mRNA decay (NMD) by a new chemical molecule reveals the dynamic of NMD factors in P-bodies

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12 December 2020

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

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12 December 2020

hUPF2 silencing identifies physiologic substrates of mammalian nonsense-mediated mRNA decay

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12 December 2020

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

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12 December 2020

Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay

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12 December 2020

Targeting of aberrant mRNAs to cytoplasmic processing bodies

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12 December 2020

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

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12 December 2020

Staufen1 regulates diverse classes of mammalian transcripts

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12 December 2020

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor

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12 December 2020

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

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12 December 2020

Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.

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12 December 2020

mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

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12 December 2020

A new kind of informational suppression in the nematode Caenorhabditis elegans

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12 December 2020

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

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12 December 2020

Protein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomerase

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12 December 2020

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.

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12 December 2020

The role of SMG-1 in nonsense-mediated mRNA decay.

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12 December 2020

Regulation of multiple core spliceosomal proteins by alternative splicing-coupled nonsense-mediated mRNA decay

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12 December 2020

A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infection

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12 December 2020

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

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12 December 2020

The mammalian RNA-binding protein Staufen2 links nuclear and cytoplasmic RNA processing pathways in neurons

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12 December 2020

Upf1, an RNA helicase required for nonsense-mediated mRNA decay, modulates the transcriptional response to oxidative stress in fission yeast

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12 December 2020

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'

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12 December 2020

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

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12 December 2020

mRNA surveillance by the Caenorhabditis elegans smg genes

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12 December 2020

Functional analysis of the interplay between translation termination, selenocysteine codon context, and selenocysteine insertion sequence-binding protein 2.

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12 December 2020

Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay

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12 December 2020

Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta

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12 December 2020

Functional characterization in vivo of mutant p53 molecules derived from squamous cell carcinomas of the head and neck

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12 December 2020

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

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12 December 2020

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

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12 December 2020

Purification and characterization of the Upf1 protein: a factor involved in translation and mRNA degradation

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12 December 2020

The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs

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12 December 2020

Regulation of telomerase by telomeric proteins

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12 December 2020

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

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12 December 2020

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

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12 December 2020

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

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12 December 2020

P bodies and the control of mRNA translation and degradation

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12 December 2020

Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

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12 December 2020

Functions of the nonsense-mediated mRNA decay pathway in Drosophila development

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12 December 2020

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

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12 December 2020

Molecular basis for dominantly inherited inclusion body beta-thalassemia

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12 December 2020

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

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12 December 2020

PTC124 targets genetic disorders caused by nonsense mutations

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12 December 2020

New ways to meet your (3') end oligouridylation as a step on the path to destruction

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12 December 2020

Effectiveness of PTC124 treatment of cystic fibrosis caused by nonsense mutations: a prospective phase II trial

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12 December 2020

The exosome: a multipurpose RNA-decay machine

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12 December 2020

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

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12 December 2020

Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats.

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12 December 2020

staufen, a gene required to localize maternal RNAs in the Drosophila egg

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12 December 2020

Eukaryotic mRNA decapping

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12 December 2020

The role of Upf proteins in modulating the translation read-through of nonsense-containing transcripts

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12 December 2020

PIN domains in nonsense-mediated mRNA decay and RNAi

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12 December 2020

Interaction of influenza virus NS1 protein and the human homologue of Staufen in vivo and in vitro

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12 December 2020

mRNAs encoding telomerase components and regulators are controlled by UPF genes in Saccharomyces cerevisiae

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12 December 2020

The highways and byways of mRNA decay

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12 December 2020

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

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12 December 2020

Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

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12 December 2020

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

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12 December 2020

mRNA surveillance of expressed pseudogenes in C. elegans.

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12 December 2020

Unexpected roles for UPF1 in HIV-1 RNA metabolism and translation

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12 December 2020

Nonsense-mediated decay approaches the clinic

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12 December 2020

Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast

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12 December 2020

10.1007/S00018-009-0177-1

Identifiers

DOI

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21 August 2017

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