Endolysosomal proteases and their inhibitors in immunity. (Q37638201)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19935806%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

review article

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title

Endolysosomal proteases and their inhibitors in immunity (English)

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12 February 2020

1

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12 February 2020

Joseph A. Trapani

2

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12 February 2020

Jose A. Villadangos

3

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12 February 2020

author name string

Phillip I Bird

1

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21 August 2017

Joseph A Trapani

2

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21 August 2017

José A Villadangos

3

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21 August 2017

1 December 2009

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19935806%20AND%20SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

12 February 2020

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19935806%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

9

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12 February 2020

issue

12

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12 February 2020

page(s)

871-882

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Lysosome-related organelles

12 February 2020

cites work

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The lysosomal cysteine proteases in MHC class II antigen presentation

31 March 2020

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Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages

31 March 2020

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Murine cathepsin F deficiency causes neuronal lipofuscinosis and late-onset neurological disease

31 March 2020

1 reference

Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone.

31 March 2020

1 reference

Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice.

31 March 2020

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Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments

31 March 2020

1 reference

The cytoplasmic tail of invariant chain regulates endosome fusion and morphology

31 March 2020

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Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain

31 March 2020

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MIF signal transduction initiated by binding to CD74

31 March 2020

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Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival.

31 March 2020

1 reference

Mhc-guided processing: binding of large antigen fragments

31 March 2020

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Asparaginyl endopeptidase: case history of a class II MHC compartment protease.

31 March 2020

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Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP.

31 March 2020

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Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing.

31 March 2020

1 reference

Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes

31 March 2020

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Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo.

31 March 2020

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The cell biology of cross-presentation and the role of dendritic cell subsets

31 March 2020

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Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo

31 March 2020

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IRAP identifies an endosomal compartment required for MHC class I cross-presentation

31 March 2020

1 reference

Chloroquine enhances human CD8+ T cell responses against soluble antigens in vivo

31 March 2020

1 reference

The small GTPase Rac2 controls phagosomal alkalinization and antigen crosspresentation selectively in CD8(+) dendritic cells

31 March 2020

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Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity

31 March 2020

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The protease inhibitor cystatin C is differentially expressed among dendritic cell populations, but does not control antigen presentation.

31 March 2020

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Developmental regulation of invariant chain proteolysis controls MHC class II trafficking in mouse dendritic cells.

31 March 2020

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MHC Class II Expression Is Regulated in Dendritic Cells Independently of Invariant Chain Degradation

31 March 2020

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Leukocystatin, a new Class II cystatin expressed selectively by hematopoietic cells

31 March 2020

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Cystatin F is a glycosylated human low molecular weight cysteine proteinase inhibitor

31 March 2020

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Inhibitory properties of cystatin F and its localization in U937 promonocyte cells

31 March 2020

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Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

31 March 2020

1 reference

Toll-like receptor control of the adaptive immune responses

31 March 2020

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Dendritic cells in a mature age.

31 March 2020

1 reference

Toll-like receptors in systemic autoimmune disease

31 March 2020

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How dying cells alert the immune system to danger

31 March 2020

1 reference

A cell biological view of Toll-like receptor function: regulation through compartmentalization.

31 March 2020

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TLR9 signals after translocating from the ER to CpG DNA in the lysosome

31 March 2020

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TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA.

31 March 2020

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The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

31 March 2020

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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling

31 March 2020

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UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

31 March 2020

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Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

31 March 2020

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The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

31 March 2020

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Cathepsins are required for Toll-like receptor 9 responses

31 March 2020

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Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

31 March 2020

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Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.

31 March 2020

1 reference

The genome of the blood fluke Schistosoma mansoni

31 March 2020

1 reference

Erratum: Slow earthquakes triggered by typhoons

31 March 2020

1 reference

An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host.

31 March 2020

1 reference

Proteases in parasitic diseases

31 March 2020

1 reference

The Leishmania mexicana cysteine protease, CPB2.8, induces potent Th2 responses

31 March 2020

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Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity

31 March 2020

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Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions.

31 March 2020

1 reference

The neutral cysteine proteinase of Entamoeba histolytica degrades IgG and prevents its binding

31 March 2020

1 reference

IdeS and SpeB: immunoglobulin-degrading cysteine proteinases of Streptococcus pyogenes

31 March 2020

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Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG.

31 March 2020

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The human protease inhibitor cystatin C is an activating cofactor for the streptococcal cysteine protease IdeS.

31 March 2020

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A surface amebic cysteine proteinase inactivates interleukin-18.

31 March 2020

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Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway

31 March 2020

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Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis

31 March 2020

1 reference

A mechanism for the initiation of allergen-induced T helper type 2 responses

31 March 2020

1 reference

MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.

31 March 2020

1 reference

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response

31 March 2020

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Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.

31 March 2020

1 reference

The molecular basis of allergenicity.

31 March 2020

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House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

31 March 2020

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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

31 March 2020

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Inhibitory effects of recombinant human cystatin C on human coronaviruses

31 March 2020

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The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells

31 March 2020

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Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response

31 March 2020

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Signaling events leading to the curative effect of cystatin on experimental visceral leishmaniasis: involvement of ERK1/2, NF-kappaB and JAK/STAT pathways

31 March 2020

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Immunomodulatory properties of cystatins

31 March 2020

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Modulation of host immune responses by nematode cystatins

31 March 2020

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Bm-CPI-2, a cystatin homolog secreted by the filarial parasite Brugia malayi, inhibits class II MHC-restricted antigen processing.

31 March 2020

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Modulation of human T cell responses and macrophage functions by onchocystatin, a secreted protein of the filarial nematode Onchocerca volvulus

31 March 2020

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A filarial cysteine protease inhibitor down-regulates T cell proliferation and enhances interleukin-10 production

31 March 2020

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Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response

31 March 2020

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Apoptosis induced by the lymphocyte effector molecule perforin

31 March 2020

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The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation

31 March 2020

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Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

31 March 2020

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Granzyme B is expressed in mouse mast cells in vivo and in vitro and causes delayed cell death independent of perforin.

31 March 2020

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Granzymes: exogenous proteinases that induce target cell apoptosis.

31 March 2020

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Secretory mechanisms in cell-mediated cytotoxicity

31 March 2020

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Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells

31 March 2020

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A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

31 March 2020

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Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

31 March 2020

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Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

31 March 2020

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Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma

31 March 2020

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The molecular basis for perforin oligomerization and transmembrane pore assembly

31 March 2020

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Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

31 March 2020

1 reference

Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

31 March 2020

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Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

31 March 2020

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Granzyme B short-circuits the need for caspase 8 activity during granule-mediated cytotoxic T-lymphocyte killing by directly cleaving Bid.

31 March 2020

1 reference

The major human and mouse granzymes are structurally and functionally divergent

31 March 2020

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Human and murine granzyme B exhibit divergent substrate preferences

31 March 2020

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Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs

31 March 2020

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Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

31 March 2020

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The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

31 March 2020

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Granzyme A loading induces rapid cytolysis and a novel form of DNA damage independently of caspase activation

31 March 2020

1 reference

Granzyme M mediates a novel form of perforin-dependent cell death

31 March 2020

1 reference

Natural killer cell-derived human granzyme H induces an alternative, caspase-independent cell-death program

31 March 2020

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Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.

31 March 2020

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Cutting edge: rapid and efficient in vivo cytotoxicity by cytotoxic T cells is independent of granzymes A and B.

31 March 2020

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Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

31 March 2020

1 reference

Extracellular granzymes: current perspectives

31 March 2020

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Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition

31 March 2020

1 reference

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

31 March 2020

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Human and mouse granzyme A induce a proinflammatory cytokine response.

31 March 2020

1 reference

31 March 2020

Lysosomal labilization

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Lysosomal membrane permeabilization in cell death

31 March 2020

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Lysosomal cysteine proteases: structural features and their role in apoptosis

31 March 2020

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Cathepsins: key modulators of cell death and inflammatory responses

31 March 2020

1 reference

Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation

31 March 2020

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Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

31 March 2020

1 reference

The human brm protein is cleaved during apoptosis: the role of cathepsin G

31 March 2020

1 reference

Tumor necrosis factor-alpha-associated lysosomal permeabilization is cathepsin B dependent

31 March 2020

1 reference

Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

31 March 2020

1 reference

Lysosomal destabilization contributes to apoptosis of germinal center B-lymphocytes

31 March 2020

1 reference

Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance

31 March 2020

1 reference

TNFalpha-induced macrophage death via caspase-dependent and independent pathways

31 March 2020

1 reference

Granzyme B leakage-induced cell death: a new type of activation-induced natural killer cell death.

31 March 2020

1 reference

Apoptotic death concurrent with CD3 stimulation in primary human CD8+ T lymphocytes: a role for endogenous granzyme B

31 March 2020

1 reference

Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells

31 March 2020

1 reference

The role of cystatins in cells of the immune system

31 March 2020

1 reference

Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1)

31 March 2020

1 reference

The role of serpins in vertebrate immunity

31 March 2020

1 reference

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

31 March 2020

1 reference

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

31 March 2020

1 reference

Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules

31 March 2020

1 reference

NF-kappaB protects from the lysosomal pathway of cell death.

31 March 2020

1 reference

Serine protease inhibitor 2A inhibits caspase-independent cell death

31 March 2020

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Serine protease inhibitor 2A is a protective factor for memory T cell development

31 March 2020

1 reference

Emerging functions of placental cathepsins

31 March 2020

1 reference

Comparison of Human Chromosome 6p25 with Mouse Chromosome 13 Reveals a Greatly Expanded Ov-Serpin Gene Repertoire in the Mouse

31 March 2020

1 reference

Mouse stefins A1 and A2 (Stfa1 and Stfa2) differentiate between papain-like endo- and exopeptidases

31 March 2020

1 reference

Protease inhibitors and their peptidomimetic derivatives as potential drugs

31 March 2020

1 reference

Role of cysteine cathepsins in matrix degradation and cell signalling

31 March 2020

1 reference

Thyroid functions of mouse cathepsins B, K, and L.

31 March 2020

1 reference

A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor

31 March 2020

1 reference

Lymphoid apoptosis and myeloid hyperplasia in CCAAT displacement protein mutant mice

31 March 2020

1 reference

The multiple roles of CUX1: insights from mouse models and cell-based assays

31 March 2020

1 reference

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation

31 March 2020

1 reference

Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite

31 March 2020

1 reference

12 December 2020

Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response.

1 reference

12 December 2020

Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L.

1 reference

12 December 2020

Cysteine proteinases and the pathogenesis of amebiasis

1 reference

12 December 2020

Cystatin C, a human proteinase inhibitor, blocks replication of herpes simplex virus

1 reference

12 December 2020

Intracellular routes and selective retention of antigens in mildly acidic cathepsin D/lysosome-associated membrane protein-1/MHC class II-positive vesicles in immature dendritic cells

1 reference

12 December 2020

The Schistosoma japonicum genome reveals features of host-parasite interplay

1 reference

12 December 2020

Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI2671

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19935806%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

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