pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner (Q37666827)

21 August 2017

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner (English)

1 reference

21 August 2017

17

William G Kaelin

1 reference

21 August 2017

14

Sabina Signoretti

1 reference

21 August 2017

Jianping Guo

1

1 reference

21 August 2017

Abhishek A Chakraborty

2

1 reference

21 August 2017

Pengda Liu

3

1 reference

21 August 2017

Wenjian Gan

4

1 reference

21 August 2017

Xingnan Zheng

5

1 reference

21 August 2017

Hiroyuki Inuzuka

6

1 reference

21 August 2017

Bin Wang

7

1 reference

21 August 2017

Jinfang Zhang

8

1 reference

21 August 2017

Linli Zhang

9

1 reference

21 August 2017

Min Yuan

10

1 reference

21 August 2017

Jesse Novak

11

1 reference

21 August 2017

Jin Q Cheng

12

1 reference

21 August 2017

Alex Toker

13

1 reference

21 August 2017

Qing Zhang

15

1 reference

21 August 2017

John M Asara

16

1 reference

21 August 2017

Wenyi Wei

18

1 reference

21 August 2017

language of work or name

English

0 references

publication date

1 August 2016

1 reference

21 August 2017

1 reference

21 August 2017

353

1 reference

21 August 2017

6302

1 reference

21 August 2017

929-932

1 reference

VHL, the story of a tumour suppressor gene

21 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

mTOR signaling in growth control and disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Role of VHL gene mutation in human cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

The Molecule Pages database

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Regulation of protein kinase cascades by protein phosphatase 2A.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

The akt kinase: molecular determinants of oncogenicity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Increased activated Akt expression in renal cell carcinomas and prognosis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

TSC2 regulates VEGF through mTOR-dependent and -independent pathways

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5326551

A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

1 September 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Genome engineering using CRISPR-Cas9 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAD5755

Development of a carbon dioxide-capture assay in microtiter plate for aspartyl-beta-hydroxylase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27563096

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.AAD5755

1 reference

21 August 2017

0 references

1 reference

21 August 2017

1 reference