Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase (Q33850553)

29 July 2017

title

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase (English)

1 reference

29 July 2017

23

William G Kaelin

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29 July 2017

22

Steven P Gygi

1 reference

29 July 2017

20

Ronald A DePinho

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29 July 2017

Xingnan Zheng

1

1 reference

29 July 2017

Bo Zhai

2

1 reference

29 July 2017

Peppi Koivunen

3

1 reference

29 July 2017

Sandra J Shin

4

1 reference

29 July 2017

Gang Lu

5

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29 July 2017

Jiayun Liu

6

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29 July 2017

Christoph Geisen

7

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29 July 2017

Abhishek A Chakraborty

8

1 reference

29 July 2017

Javid J Moslehi

9

1 reference

29 July 2017

David M Smalley

10

1 reference

29 July 2017

Xin Wei

11

1 reference

29 July 2017

Xian Chen

12

1 reference

29 July 2017

Zhengming Chen

13

1 reference

29 July 2017

Justine M Beres

14

1 reference

29 July 2017

Jing Zhang

15

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29 July 2017

Jen Lan Tsao

16

1 reference

29 July 2017

Mitchell C Brenner

17

1 reference

29 July 2017

Yuqing Zhang

18

1 reference

29 July 2017

Cheng Fan

19

1 reference

29 July 2017

Jihye Paik

21

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29 July 2017

Qing Zhang

24

1 reference

29 July 2017

publication date

1 July 2014

1 reference

29 July 2017

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29 July 2017

volume

28

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29 July 2017

issue

13

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29 July 2017

page(s)

1429-1444

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describes a project that uses

29 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4083087/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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28 July 2018

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28 July 2018

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Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a

28 July 2018

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28 July 2018

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Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy

28 July 2018

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28 July 2018

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HIF prolyl hydroxylase-3 mediates alpha-ketoglutarate-induced apoptosis and tumor suppression

28 July 2018

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

28 July 2018

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Divergent mechanisms controlling hypoxic sensitivity and lifespan by the DAF-2/insulin/IGF-receptor pathway

28 July 2018

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Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase

28 July 2018

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A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo

28 July 2018

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Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Abnormal sympathoadrenal development and systemic hypotension in PHD3-/- mice

28 July 2018

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ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

28 July 2018

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28 July 2018

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Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Failure to prolyl hydroxylate hypoxia-inducible factor alpha phenocopies VHL inactivation in vivo

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1

28 July 2018

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

28 July 2018

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28 July 2018

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Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway

28 July 2018

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Forkhead box transcription factor FOXO3a regulates estrogen receptor alpha expression and is repressed by the Her-2/neu/phosphatidylinositol 3-kinase/Akt signaling pathway

28 July 2018

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

28 July 2018

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IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a

28 July 2018

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Protein kinase B-alpha inhibits human pyruvate dehydrogenase kinase-4 gene induction by dexamethasone through inactivation of FOXO transcription factors

28 July 2018

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FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines

28 July 2018

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

28 July 2018

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Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D.

28 July 2018

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Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

28 July 2018

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A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

28 July 2018

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14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport

28 July 2018

1 reference

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Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

28 July 2018

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A conserved family of prolyl-4-hydroxylases that modify HIF

28 July 2018

1 reference

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

28 July 2018

1 reference

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4083087

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

28 July 2018

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

28 July 2018

1 reference

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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

28 July 2018

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

28 July 2018

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FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity

28 July 2018

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FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

29 October 2018

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

29 October 2018

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

29 October 2018

1 reference

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FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.

29 October 2018

1 reference

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Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification

29 October 2018

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Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity

29 October 2018

1 reference

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A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen

29 October 2018

1 reference

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Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer

29 October 2018

1 reference

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Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells.

29 October 2018

1 reference

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

29 October 2018

1 reference

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Regulation of hypoxic death in C. elegans by the insulin/IGF receptor homolog DAF-2.

29 October 2018

1 reference

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Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction

29 October 2018

1 reference

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Development of a carbon dioxide-capture assay in microtiter plate for aspartyl-beta-hydroxylase

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24990963

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.242131.114

1 reference

29 July 2017

1 reference

29 July 2017

1 reference