Pharmacogenetics of drug-induced liver injury (Q37770487)

22 August 2017

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title

Pharmacogenetics of drug-induced liver injury (English)

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22 August 2017

Stefan Russmann

1

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22 August 2017

Alexander Jetter

series ordinal

2

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22 August 2017

Gerd A Kullak-Ublick

series ordinal

3

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22 August 2017

language of work or name

English

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publication date

1 August 2010

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22 August 2017

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22 August 2017

52

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22 August 2017

2

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22 August 2017

748-761

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HLA-B*5701 screening for hypersensitivity to abacavir

22 August 2017

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Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research Database

21 January 2018

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Incidence of drug-induced hepatic injuries: a French population-based study

21 January 2018

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The role of metabolic activation in drug-induced hepatotoxicity

21 January 2018

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Role of metabolism in drug-induced idiosyncratic hepatotoxicity

21 January 2018

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Idiosyncratic drug hepatotoxicity

21 January 2018

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Hepatotoxicity due to mitochondrial dysfunction

21 January 2018

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Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

21 January 2018

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Current concepts of mechanisms in drug-induced hepatotoxicity

21 January 2018

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Delayed drug hypersensitivity reactions - new concepts

21 January 2018

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HLA class II genotype influences the type of liver injury in drug-induced idiosyncratic liver disease

21 January 2018

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The danger hypothesis applied to idiosyncratic drug reactions

21 January 2018

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Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity

21 January 2018

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Ethanol and production of the hepatotoxic metabolite of acetaminophen in healthy adults.

21 January 2018

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Glutathione deficiency in alcoholics: risk factor for paracetamol hepatotoxicity

21 January 2018

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Decreased glutathione in patients with anorexia nervosa. Risk factor for toxic liver injury?

21 January 2018

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Adverse Reactions to Trimethoprim-Sulfamethoxazole in Patients with the Acquired Immunodeficiency Syndrome

21 January 2018

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Pretreatment of chronic active hepatitis C in patients coinfected with HIV and hepatitis C virus reduces the hepatotoxicity associated with subsequent antiretroviral therapy

21 January 2018

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Hepatotoxicity of antitubercular treatments. Rationale for monitoring liver status

21 January 2018

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Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals

21 January 2018

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Acute and clinically relevant drug-induced liver injury: a population based case-control study.

21 January 2018

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Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity

21 January 2018

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Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury.

21 January 2018

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Analysis of IL-10, IL-4 and TNF-alpha polymorphisms in drug-induced liver injury (DILI) and its outcome

21 January 2018

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The role of FXR in disorders of bile acid homeostasis

21 January 2018

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Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis

21 January 2018

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Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans

21 January 2018

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Haplotypic analysis of Wellcome Trust Case Control Consortium data

21 January 2018

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The structure of haplotype blocks in the human genome

21 January 2018

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

21 January 2018

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HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

21 January 2018

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Candidate gene case-control association studies: advantages and potential pitfalls

21 January 2018

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Genomewide association studies and human disease

21 January 2018

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Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.

21 January 2018

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Pharmacogenetics and drug development: the path to safer and more effective drugs

21 January 2018

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Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States

21 January 2018

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Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries

21 January 2018

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Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis

21 January 2018

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Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions

21 January 2018

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Practical aspects of imputation-driven meta-analysis of genome-wide association studies

21 January 2018

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Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

21 January 2018

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21 January 2018

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Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI)

21 January 2018

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Relationship of polymorphism in CYP2C9 to genetic susceptibility to diclofenac-induced hepatitis

21 January 2018

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Leflunomide-induced acute hepatitis

21 January 2018

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Acetaminophen-induced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition

21 January 2018

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CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

21 January 2018

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CYP2E1 and oxidative liver injury by alcohol

21 January 2018

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Inhibition of cytochrome P450 (CYP450) isoforms by isoniazid: potent inhibition of CYP2C19 and CYP3A

21 January 2018

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Inhibition and induction of cytochrome P4502E1-catalyzed oxidation by isoniazid in humans

21 January 2018

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Arylamine N-acetyltransferase-2 genotypes in the Thai population.

21 January 2018

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Genetic polymorphisms of drug-metabolizing enzymes and the susceptibility to antituberculosis drug-induced liver injury

21 January 2018

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A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

21 January 2018

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Influence of glutathione S-transferase M1 and T1 homozygous null mutations on the risk of antituberculosis drug-induced hepatotoxicity in a Caucasian population.

21 January 2018

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Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity.

21 January 2018

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Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

21 January 2018

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A systems biology approach to understanding elevated serum alanine transaminase levels in a clinical trial with ximelagatran

21 January 2018

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HLA association of amoxicillin-clavulanate--induced hepatitis

21 January 2018

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Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment

21 January 2018

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Molecular and genetic association of interleukin-6 in tacrine-induced hepatotoxicity.

21 January 2018

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Nimesulide-induced hepatic mitochondrial injury in heterozygous Sod2(+/-) mice

21 January 2018

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The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity

21 January 2018

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Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice

21 January 2018

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The bile salt export pump

21 January 2018

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Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families.

21 January 2018

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Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy

21 January 2018

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Interindividual variability of canalicular ATP-binding-cassette (ABC)-transporter expression in human liver.

21 January 2018

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Genetic variations of the ABC transporter gene ABCB11 encoding the human bile salt export pump (BSEP) in a Japanese population

21 January 2018

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Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

21 January 2018

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MRP2 haplotypes confer differential susceptibility to toxic liver injury

21 January 2018

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Enterohepatic bile salt transporters in normal physiology and liver disease

21 January 2018

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Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

21 January 2018

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Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

21 January 2018

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Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.

21 January 2018

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Pharmacogenetics of OATP (SLC21/SLCO), OAT and OCT (SLC22) and PEPT (SLC15) transporters in the intestine, liver and kidney

21 January 2018

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SLCO1B1 variants and statin-induced myopathy--a genomewide study

21 January 2018

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Impact of OATP transporters on pharmacokinetics

21 January 2018

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Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

21 January 2018

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Fatal liver failure with atorvastatin

21 January 2018

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Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

21 January 2018

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Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

21 January 2018

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Bioactivation of flutamide metabolites by human liver microsomes

21 January 2018

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Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update

21 January 2018

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Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s

21 January 2018

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Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy

21 January 2018

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Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans

21 January 2018

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'Hy's law,' the 'Rezulin Rule,' and other predictors of severe drug-induced hepatotoxicity: putting risk-benefit into perspective

21 January 2018

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Hepatic findings in long-term clinical trials of ximelagatran

21 January 2018

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Pharmacogenetics: from discovery to patient care

21 January 2018

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Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities

21 January 2018

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7 January 2021

Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis

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7 January 2021

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7 January 2021

Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone

1 reference

7 January 2021

Influence of polymorphic N-acetyltransferase phenotype on the inhibition and induction of acetaminophen bioactivation with long-term isoniazid

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7 January 2021

Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period

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7 January 2021

Causality assessment versus guilt-by-association in drug hepatotoxicity

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7 January 2021

Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2

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7 January 2021

Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

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7 January 2021

Genetic polymorphisms of manganese superoxide dismutase, NAD(P)H:quinone oxidoreductase, glutathione S-transferase M1 and T1, and the susceptibility to drug-induced liver injury

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7 January 2021

Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury

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7 January 2021

A common polymorphism in the bile acid receptor farnesoid X receptor is associated with decreased hepatic target gene expression

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7 January 2021

Observations of alanine aminotransferase and aspartate aminotransferase in THRIVE studies treated orally with ximelagatran

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7 January 2021

Identifiers

DOI

10.1002/HEP.23720

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22 August 2017

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