Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization (Q37778010)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

review article

1 reference

title

Role of the p53 family in stabilizing the genome and preventing polyploidization (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Role of the p53 Family in Stabilizing the Genome and Preventing Polyploidization (English)

1 reference

https://api.crossref.org/works/10.1007/978-1-4419-6199-0_5

17 June 2024

main subject

whole genome duplication

1 reference

1 reference

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17 June 2024

author name string

Flaminia Talos

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

Ute M. Moll

2

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17 June 2024

language of work or name

English

0 references

publication date

1 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

full work available at URL

9 February 2020

number of pages

19

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based on heuristic

inferred from page(s)

http://link.springer.com/content/pdf/10.1007/978-1-4419-6199-0_5.pdf

file format

Portable Document Format

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Advances in Experimental Medicine and Biology

17 June 2024

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

volume

676

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

page(s)

73-91

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

9 February 2020

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Abnormal centrosome amplification in the absence of p53.

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Genetic instability as a consequence of inappropriate entry into and progression through S-phase.

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BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination

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Tumor suppressor p53 represses transcription of RECQ4 helicase

17 June 2024

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A role for ATR in the DNA damage-induced phosphorylation of p53

17 June 2024

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

17 June 2024

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p53 prevents the accumulation of double-strand DNA breaks at stalled-replication forks induced by UV in human cells

17 June 2024

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p53-dependent cell cycle control: response to genotoxic stress

17 June 2024

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Regulation of the G2/M transition by p53.

17 June 2024

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p53: traffic cop at the crossroads of DNA repair and recombination

17 June 2024

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Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

17 June 2024

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Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

17 June 2024

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

17 June 2024

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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

17 June 2024

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

17 June 2024

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p53 Protein exhibits 3'-to-5' exonuclease activity

17 June 2024

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p53 is linked directly to homologous recombination processes via RAD51/RecA protein interaction

17 June 2024

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p53's double life: transactivation-independent repression of homologous recombination.

17 June 2024

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The DNA damage response: putting checkpoints in perspective

17 June 2024

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On the road to cancer: aneuploidy and the mitotic checkpoint

17 June 2024

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G1 tetraploidy checkpoint and the suppression of tumorigenesis

17 June 2024

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17 June 2024

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17 June 2024

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17 June 2024

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

17 June 2024

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From polyploidy to aneuploidy, genome instability and cancer

17 June 2024

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The advantages and disadvantages of being polyploid

17 June 2024

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17 June 2024

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Centrosome multiplication accompanies a transient clustering of polyploid cells during tissue repair

17 June 2024

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Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity

17 June 2024

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17 June 2024

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Chromatin of endoreduplicated pavement cells has greater range of movement than that of diploid guard cells in Arabidopsis thaliana

17 June 2024

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The nuclear envelope, a key structure in cellular integrity and gene expression

17 June 2024

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High levels of chromosome instability in polyploids of Saccharomyces cerevisiae

17 June 2024

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17 June 2024

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Polyploidization increases the sensitivity to DNA-damaging agents in mammalian cells

17 June 2024

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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Tetraploid state induces p53-dependent arrest of nontransformed mammalian cells in G1.

17 June 2024

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Female embryonic lethality in mice nullizygous for both Msh2 and p53

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A role for mismatch repair in control of DNA ploidy following DNA damage

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A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

17 June 2024

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

17 June 2024

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p63 is a p53 homologue required for limb and epidermal morphogenesis

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Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

17 June 2024

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p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo.

17 June 2024

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p63 deficiency activates a program of cellular senescence and leads to accelerated aging

17 June 2024

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p73 is not mutated in meningiomas as determined with a functional yeast assay but p73 expression increases with tumor grade.

17 June 2024

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Transdominant DeltaTAp73 isoforms are frequently up-regulated in ovarian cancer. Evidence for their role as epigenetic p53 inhibitors in vivo

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

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P73 functionally replaces p53 in Adriamycin-treated, p53-deficient breast cancer cells

17 June 2024

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A common E2F-1 and p73 pathway mediates cell death induced by TCR activation.

17 June 2024

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p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

17 June 2024

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p73 suppresses polyploidy and aneuploidy in the absence of functional p53

17 June 2024

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Near-triploidy and near-tetraploidy in hematological malignancies and mutation of the p53 gene

17 June 2024

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17 June 2024

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p27 as a target for cancer therapeutics

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17 June 2024

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17 June 2024

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Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1

17 June 2024

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17 June 2024

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17 June 2024

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17 June 2024

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Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

17 June 2024

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17 June 2024

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RB signaling prevents replication-dependent DNA double-strand breaks following genotoxic insult

17 June 2024

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Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

17 June 2024

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17 June 2024

Identifiers

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20687470%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference