Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy (Q37781356)

23 August 2017

Pharmacological modulation of voltage-gated potassium channels as a therapeutic strategy (English)

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23 August 2017

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Neil A Castle

1

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PubMed ID

20726689

23 August 2017

language of work or name

English

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publication date

20 August 2010

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Expert Opinion on Therapeutic Patents

23 August 2017

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23 August 2017

20

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23 August 2017

11

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23 August 2017

1471-1503

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Therapeutic approaches to ion channel diseases

23 August 2017

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https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Guide to Receptors and Channels (GRAC), 3rd edition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Towards a structural view of gating in potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Ancillary subunits associated with voltage-dependent K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

New drugs targeting the cardiac ultra-rapid delayed-rectifier current (I Kur): rationale, pharmacology and evidence for potential therapeutic value

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Neural KCNQ (Kv7) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

New tricks for old dogs: KCNQ expression and role in smooth muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The role of Kv3-type potassium channels in cerebellar physiology and behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv7 channels as targets for the treatment of pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Voltage-gated potassium channels as therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

K(+) channels as therapeutic targets in oncology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Subunit composition of Kv1 channels in human CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

alpha subunit compositions of Kv1.1-containing K+ channel subtypes fractionated from rat brain using dendrotoxins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Deletion of the K(V)1.1 potassium channel causes epilepsy in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Production of seizures and brain damage in rats by alpha-dendrotoxin, a selective K+ channel blocker.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Temporal and spatial patterns of Kv1.1 and Kv1.2 protein and gene expression in spinal cord white matter after acute and chronic spinal cord injury in rats: implications for axonal pathophysiology after neurotrauma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The use of 4-aminopyridine (fampridine) in demyelinating disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Ion channels in the immune system as targets for immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The functional network of ion channels in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

K+ channels as targets for specific immunomodulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

A new variant in the human Kv1.3 gene is associated with low insulin sensitivity and impaired glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel, K(v)1.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Synthesis and biological evaluation of chalcones as inhibitors of the voltage-gated potassium channel Kv1.3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Potassium channels, memory T cells, and multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Aryl sulfonamido indane inhibitors of the Kv1.5 ion channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Aryl sulfonamido tetralin inhibitors of the Kv1.5 ion channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Ion channels modulating mouse dendritic cell functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Inhibition by a novel anti-arrhythmic agent, NIP-142, of cloned human cardiac K+ channel Kv1.5 current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Synthesis and evaluation of (2-phenethyl-2H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Pyrano-[2,3b]-pyridines as potassium channel antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Dihydropyrazolopyrimidines containing benzimidazoles as K(V)1.5 potassium channel antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Dihydropyrazolopyrimidine inhibitors of K(V)1.5 (I(Kur)).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

"Early" class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Pharmacophore-based search, synthesis, and biological evaluation of anthranilic amides as novel blockers of the Kv1.5 channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Properties of a time-dependent potassium current in pig atrium: evidence for a role of kv1.5 in repolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Atrial effects of the novel K(+)-channel-blocker AVE0118 in anesthetized pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Vernakalant (RSD1235): a novel, atrial-selective antifibrillatory agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The mechanism of atrial antiarrhythmic action of RSD1235.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Vernakalant hydrochloride for the treatment of atrial fibrillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

New modulatory alpha subunits for mammalian Shab K+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Voltage-gated potassium channel as a facilitator of exocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The MiRP2-Kv3.4 potassium channel: muscling in on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Structure and function of Kv4-family transient potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Safety and efficacy of intravenously administered tedisamil for rapid conversion of recent-onset atrial fibrillation or atrial flutter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The KCNQ1 potassium channel: from gene to physiological function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Kv7.1 (KCNQ1) properties and channelopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Pharmacological modulation of I(Ks): potential for antiarrhythmic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Major recent trials in cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Tetrahydronaphthalene-derived amino alcohols and amino ketones as potent and selective inhibitors of the delayed rectifier potassium current IKs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable I(Ks) blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Inhibition of IKs channels by HMR 1556.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

A potassium channel mutation in neonatal human epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

A reduced K+ current due to a novel mutation in KCNQ2 causes neonatal convulsions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Nervous system KV7 disorders: breakdown of a subthreshold brake

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

KCNQ potassium channels: new targets for pulmonary vasodilator drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Linopirdine (DUP 996): cholinergic treatment of older adults using successive and non-successive tests.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Retigabine: chemical synthesis to clinical application.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Tomorrow's asthma therapy--are antiasthmatics in the 90ties anti-inflammatory drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Refinement of the binding site and mode of action of the anticonvulsant Retigabine on KCNQ K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Novel KCNQ2/Q3 agonists as potential therapeutics for epilepsy and neuropathic pain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Recent developments on KCNQ potassium channel openers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Meclofenamic acid and diclofenac, novel templates of KCNQ2/Q3 potassium channel openers, depress cortical neuron activity and exhibit anticonvulsant properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

A tale of switched functions: from cyclooxygenase inhibition to M-channel modulation in new diphenylamine derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Anxiolytic effects of Maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

KCNQ4 channel activation by BMS-204352 and retigabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Antipsychotic-like effect of retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Cardiovascular KCNQ (Kv7) potassium channels: physiological regulators and new targets for therapeutic intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Overexpression of Eag1 potassium channels in clinical tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Effect of extracellular matrix on adhesion, viability, actin cytoskeleton and K+ currents of cells expressing human ether à go-go channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Oncogenic potential of EAG K(+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Potassium channels as tumour markers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Mechanism of block of hEag1 K+ channels by imipramine and astemizole

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Dofetilide: a new class III antiarrhythmic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Repolarization of the cardiac action potential. Does an increase in repolarization capacity constitute a new anti-arrhythmic principle?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

hERG1 channel activators: a new anti-arrhythmic principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic aci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Electrophysiologic characterization of a novel hERG channel activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Pharmacological removal of human ether-à-go-go-related gene potassium channel inactivation by 3-nitro-N-(4-phenoxyphenyl) benzamide (ICA-105574).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

HERG1 gene expression as a specific tumor marker in colorectal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

The functional properties of the human ether-à-go-go-like (HELK2) K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Cloning and functional expression of rat ether-à-go-go-like K+ channel genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

New ether-à-go-go K(+) channel family members localized in human telencephalon

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Disruption of the ether-a-go-go K+ channel gene BEC1/KCNH3 enhances cognitive function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Pharmacological therapy for atrial fibrillation: current options and new agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Abnormal axonal physiology is associated with altered expression and distribution of Kv1.1 and Kv1.2 K+channels after chronic spinal cord injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Mechanisms of axonal dysfunction after spinal cord injury: with an emphasis on the role of voltage-gated potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

21 January 2018

Eag1 as a cancer target

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

Monoclonal Antibody Blockade of the Human Eag1 Potassium Channel Function Exerts Antitumor Activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2010.513384

10.1517/13543776.2010.513384

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

20726689