Sugar-free approaches to cancer cell killing (Q37802748)

23 August 2017

Sugar-free approaches to cancer cell killing (English)

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23 August 2017

Alfredo Caro-Maldonado

object named as

A Caro-Maldonado

2

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Cristina Muñoz-Pinedo

object named as

C Muñoz-Pinedo

4

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author name string

N El Mjiyad

1

1 reference

PubMed ID

20972457

23 August 2017

S Ramírez-Peinado

3

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PubMed ID

20972457

23 August 2017

language of work or name

English

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publication date

25 October 2010

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23 August 2017

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23 August 2017

30

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23 August 2017

253-264

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23 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/onc.2010.466

23 August 2017

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cites work

Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death

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The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells

21 January 2018

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Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells

21 January 2018

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Inhibition of macroautophagy triggers apoptosis

21 January 2018

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The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

21 January 2018

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Glucose deprivation induces an atypical form of apoptosis mediated by caspase-8 in Bax-, Bak-deficient cells.

21 January 2018

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Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.466

AMP kinase-mediated activation of the BH3-only protein Bim couples energy depletion to stress-induced apoptosis

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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Dual role of proapoptotic BAD in insulin secretion and beta cell survival

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Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study

21 January 2018

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

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Therapeutic starvation and autophagy in prostate cancer: a new paradigm for targeting metabolism in cancer therapy

21 January 2018

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Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines

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Histone deacetylase inhibition and blockade of the glycolytic pathway synergistically induce glioblastoma cell death

21 January 2018

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Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

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Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition

21 January 2018

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Bcl2 family proteins in carcinogenesis and the treatment of cancer.

21 January 2018

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

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Decreased glycolytic metabolism contributes to but is not the inducer of apoptosis following IL-3-starvation

21 January 2018

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Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

21 January 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

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Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment

21 January 2018

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Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells

21 January 2018

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The TRAIL apoptotic pathway in cancer onset, progression and therapy

21 January 2018

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AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

21 January 2018

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Tumor suppressors and cell metabolism: a recipe for cancer growth

21 January 2018

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Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

21 January 2018

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2-Deoxyglucose: an anticancer and antiviral therapeutic, but not any more a low glucose mimetic

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The unfolded protein response in nutrient sensing and differentiation

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Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP.

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Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

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Under normoxia, 2-deoxy-D-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation

21 January 2018

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

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Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

The metabolic life and times of a T-cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Epigenetic control of rDNA loci in response to intracellular energy status

21 January 2018

1 reference

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PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Low glucose-enhanced TRAIL cytotoxicity is mediated through the ceramide-Akt-FLIP pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glycolysis inhibition for anticancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

A unique glucose-dependent apoptotic pathway induced by c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Regulation of autophagy by cytoplasmic p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Apoptosis: controlled demolition at the cellular level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Targeting metabolic transformation for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Understanding the Warburg effect: the metabolic requirements of cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Growth factors can influence cell growth and survival through effects on glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Nutrient control of TORC1, a cell-cycle regulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

ATP-citrate lyase links cellular metabolism to histone acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

A genome-wide RNAi screen reveals multiple regulators of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

The BCL-2 protein family: opposing activities that mediate cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Regulation of cellular metabolism by protein lysine acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Ras-dependent carbon metabolism and transformation in mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

2-Deoxyglucose inhibits chemotherapeutic drug-induced apoptosis in human monocytic leukemia U937 cells with inhibition of c-Jun N-terminal kinase 1/stress-activated protein kinase activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Effect of lonidamine on the cytotoxicity of four alkylating agents in vitro

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Effects of 5-bromo-2-deoxyuridine and 2-deoxy-D-glucose on radiation-induced micronuclei in mouse bone marrow

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Glucose-regulated stresses induce resistance to camptothecin in human cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

Cellular sensitization to cisplatin and carboplatin with decreased removal of platinum-DNA adduct by glucose-regulated stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.466

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.466

1 reference

23 August 2017

1 reference

PubMed ID

20972457