Molecular basis of iron-loading disorders. (Q37807528)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21054916%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Molecular basis of iron-loading disorders (English)

1 reference

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15 January 2020

1

1 reference

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15 January 2020

David M. Frazer

series ordinal

2

1 reference

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15 January 2020

Gregory J Anderson

series ordinal

3

1 reference

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15 January 2020

3

Gregory J Anderson

1 reference

23 August 2017

publication date

8 November 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21054916%20AND%20SRC:MED&resulttype=core&format=json

Expert Reviews in Molecular Medicine

15 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21054916%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21054916%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

page(s)

e36

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Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

15 January 2020

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1 reference

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Physiologic systemic iron metabolism in mice deficient for duodenal Hfe

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Hfe acts in hepatocytes to prevent hemochromatosis.

21 January 2018

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Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis.

21 January 2018

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The management of porphyria cutanea tarda

21 January 2018

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Neonatal hemochromatosis: a congenital alloimmune hepatitis

21 January 2018

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Hereditary ceruloplasmin deficiency with hemosiderosis: a clinicopathological study of a Japanese family

21 January 2018

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Congenital Atransferrinemia A Case Report and Review of the Literature

21 January 2018

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Transferrin therapy ameliorates disease in beta-thalassemic mice

21 January 2018

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Clinical application of deferasirox: practical patient management

21 January 2018

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21 January 2018

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Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

21 January 2018

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The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

21 January 2018

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SELDI-TOF-MS determination of hepcidin in clinical samples using stable isotope labelled hepcidin as an internal standard

21 January 2018

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Development of a novel immunoassay for the iron regulatory peptide hepcidin.

21 January 2018

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Immunoassay for human serum hepcidin

21 January 2018

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A case of iron overload cardiomyopathy: beneficial effects of iron chelating agent and calcium channel blocker on left ventricular dysfunction

21 January 2018

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L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy

21 January 2018

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Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Iron depletion limits intracellular bacterial growth in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hepatotoxicity of iron overload: mechanisms of iron-induced hepatic fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hemochromatosis and pregnancy: iron stores in the Hfe-/- mouse are not reduced by multiple pregnancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Iron-overload-related disease in HFE hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Twisted gastrulation is a conserved extracellular BMP antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Twisted gastrulation can function as a BMP antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

The role of hepcidin in iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Regulation of systemic iron homeostasis: how the body responds to changes in iron demand

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

A genome-wide association analysis of serum iron concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Effect of hepcidin on intestinal iron absorption in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Blunted hepcidin response to oral iron challenge in HFE-related hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Is iron overload in alcohol-related cirrhosis mediated by hepcidin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: need for standardization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Novel urine hepcidin assay by mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Natural history of juvenile haemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

21 January 2018

Non-HFE hemochromatosis.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hepcidin is decreased in TFR2 hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Diferric transferrin regulates transferrin receptor 2 protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Stoichiometries of transferrin receptors 1 and 2 in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Interleukin-6 induces hepcidin expression through STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Association of hepcidin promoter c.-582 A>G variant and iron overload in thalassemia major

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Regulatory variation in hepcidin expression as a heritable quantitative trait

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

THE ROLE OF THE INTESTINE IN IRON KINETICS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

The serine protease TMPRSS6 is required to sense iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Cis and trans regulation of hepcidin expression by upstream stimulatory factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Forging a field: the golden age of iron biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Suppression of the hepcidin-encoding gene Hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Bone morphogenetic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

An iron-regulated ferric reductase associated with the absorption of dietary iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Regulation of iron absorption in hemoglobinopathies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Regulation of hepcidin and iron-overload disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Nutritional iron deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Serum hepcidin level and erythropoietic activity after hematopoietic stem cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

Autocrine formation of hepcidin induces iron retention in human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

How I treat hemochromatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Targeting the hepcidin-ferroportin axis in the diagnosis and treatment of anemias

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Hereditary hemochromatosis: pathogenesis, diagnosis, and treatment

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Hepcidin decreases iron transporter expression in vivo in mouse duodenum and spleen and in vitro in THP-1 macrophages and intestinal Caco-2 cells

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Juvenile idiopathic haemochromatosis: a life-threatening disorder presenting as hypogonadotropic hypogonadism

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

African iron overload

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Clinical aspects of hemochromatosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Pathology of hepatic iron overload

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Oxidative stress and iron homeostasis: mechanistic and health aspects

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

The physiology of transferrin and transferrin receptors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Genetic mechanisms and modifying factors in hereditary hemochromatosis.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

High-sensitive radioimmunoassay for human serum hepcidin

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Molecular advantage of diferric transferrin in delivering iron to reticulocytes: a comparative study.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Anemia of chronic disease (anemia of inflammation)

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Post-prandial iron absorption in humans: comparison between HFE genotypes and iron deficiency anaemia

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

https://api.crossref.org/works/10.1017%2FS1462399410001687

1 reference

7 January 2021

Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001687

7 January 2021

10.1017/S1462399410001687

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21054916%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

1 reference