The PI3K signaling pathway mediates the biological effects of leptin (Q37810478)

23 August 2017

The PI3K signaling pathway mediates the biological effects of leptin (English)

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23 August 2017

Carol Fuzeti Elias

3

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author name string

Jose Donato

series ordinal

1

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PubMed ID

21085763

23 August 2017

Renata Frazão

series ordinal

2

1 reference

23 August 2017

1 October 2010

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Arquivos Brasileiros de Endocrinologia e Metabologia

23 August 2017

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23 August 2017

54

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23 August 2017

591-602

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23 August 2017

7

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Therapeutic potential of phosphoinositide 3-kinase inhibitors.

23 August 2017

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Should individual PI3 kinase isoforms be targeted in cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

From observation to experimentation: leptin action in the mediobasal hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Central nervous system regulation of food intake

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Hypothalamic regulation of food intake and clinical therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Weight-reducing effects of the plasma protein encoded by the obese gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Role of leptin in the neuroendocrine response to fasting

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin receptor signaling and the regulation of mammalian physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

STAT3 signalling is required for leptin regulation of energy balance but not reproduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin targets in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

The ventral premammillary nucleus links fasting-induced changes in leptin levels and coordinated luteinizing hormone secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Attenuation of leptin and insulin signaling by SOCS proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Intracellular signalling. Key enzyme in leptin-induced anorexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

p110δ, a novel phosphoinositide 3-kinase in leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Both p110alpha and p110beta isoforms of phosphatidylinositol 3-OH-kinase are required for insulin signalling in the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Tumor suppressor PTEN inhibits integrin- and growth factor-mediated mitogen-activated protein (MAP) kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Epidemiological and molecular mechanisms aspects linking obesity and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Obesity, the PI3K/Akt signal pathway and colon cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302010000700002

10.1590/S0004-27302010000700002

21 January 2018

Identifiers

DOI

1 reference

23 August 2017

1 reference

PubMed ID

21085763