Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target? (Q37820481)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

review article

1 reference

title

Intracellular amino acid sensing and mTORC1-regulated growth: new ways to block an old target? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Deborah C I Goberdhan

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

1 reference

1 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

Current Opinion in Investigational Drugs

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

1360-1367

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2)

18 January 2020

cites work

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

6 September 2017

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mTOR signaling and drug development in cancer

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Single amino-acid changes that confer constitutive activation of mTOR are discovered in human cancer

6 September 2017

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6 September 2017

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The late endosome is essential for mTORC1 signaling

6 September 2017

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Vascular endothelial growth factor and mTOR pathways in renal cell carcinoma: differences and synergies of two targeted mechanisms

6 September 2017

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mTOR signaling at a glance

6 September 2017

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Functioning and evolutionary significance of nutrient transceptors.

6 September 2017

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Caloric restriction delays disease onset and mortality in rhesus monkeys

6 September 2017

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Nutrient control of TORC1, a cell-cycle regulator

6 September 2017

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The orally active antihyperglycemic drug beta-guanidinopropionic acid is transported by the human proton-coupled amino acid transporter hPAT1.

6 September 2017

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Bidirectional transport of amino acids regulates mTOR and autophagy

6 September 2017

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A new fork for clinical application: targeting forkhead transcription factors in cancer

6 September 2017

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Amino acid transceptors: gate keepers of nutrient exchange and regulators of nutrient signaling

6 September 2017

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Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters

6 September 2017

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Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond

6 September 2017

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Missense mutation in exon 2 of SLC36A1 responsible for champagne dilution in horses

6 September 2017

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Amino acid regulation of TOR complex 1.

6 September 2017

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Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial

6 September 2017

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6 September 2017

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

6 September 2017

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The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling

6 September 2017

1 reference

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Deciphering the mechanisms of intestinal imino (and amino) acid transport: the redemption of SLC36A1.

6 September 2017

1 reference

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A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast

6 September 2017

1 reference

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

6 September 2017

1 reference

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Fatty acids and insulin resistance in muscle and liver

6 September 2017

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase.

6 September 2017

1 reference

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Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1.

6 September 2017

1 reference

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Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).

6 September 2017

1 reference

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Cancer, type 2 diabetes, and ageing: news from flies and worms

6 September 2017

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A novel bifunctionality: PAT1 and PAT2 mediate electrogenic proton/amino acid and electroneutral proton/fatty acid symport

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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PTEN: tumour suppressor, multifunctional growth regulator and more

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2

6 September 2017

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Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve

6 September 2017

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Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters

6 September 2017

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Identification and characterization of a lysosomal transporter for small neutral amino acids

6 September 2017

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A family of yeast proteins mediating bidirectional vacuolar amino acid transport

6 September 2017

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

6 September 2017

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Chemical neurotransmission: an hypothesis concerning the evolution of neurotransmitter substances

6 September 2017

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Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation

6 September 2017

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PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.

14 September 2017

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Delta-aminolevulinic acid is a substrate for the amino acid transporter SLC36A1 (hPAT1).

14 September 2017

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hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase

14 September 2017

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Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34.

14 September 2017

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Human muscle protein synthesis is modulated by extracellular, not intramuscular amino acid availability: a dose-response study

23 June 2018

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Regulation of targets of mTOR (mammalian target of rapamycin) signalling by intracellular amino acid availability

23 June 2018

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Transporters for cationic amino acids in animal cells: discovery, structure, and function

23 June 2018

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MAP4K3 regulates body size and metabolism in Drosophila

23 June 2018

1 reference

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Renal imino acid and glycine transport system ontogeny and involvement in developmental iminoglycinuria.

1 September 2018

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1 September 2018

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Transport of the photodynamic therapy agent 5-aminolevulinic acid by distinct H+-coupled nutrient carriers coexpressed in the small intestine

1 September 2018

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1 September 2018

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Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1.

1 September 2018

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1 September 2018

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Nitrate signalling mediated by the NRT1.1 nitrate transporter antagonises L-glutamate-induced changes in root architecture

1 September 2018

1 reference

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1 September 2018

1 reference

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Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability.

1 September 2018

1 reference

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Substrate specificity of the amino acid transporter PAT1.

1 September 2018

1 reference

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1 September 2018

1 reference

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The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae

1 September 2018

1 reference

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Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044466

Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044466

1 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21154118

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21154118%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference