Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s (Q37823851)

23 August 2017

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title

Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s (English)

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23 August 2017

2

Katalin Monostory

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author name string

Viola Tamási

1

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23 August 2017

Katalin Monostory

2

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23 August 2017

Russell A Prough

3

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23 August 2017

András Falus

4

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23 August 2017

24 December 2010

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Cellular and Molecular Life Sciences

23 August 2017

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23 August 2017

68

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23 August 2017

7

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23 August 2017

1131-1146

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https://scigraph.springernature.com/pub.10.1007/s00018-010-0600-7

23 August 2017

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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The far and distal enhancers in the CYP3A4 gene co-ordinate the proximal promoter in responding similarly to the pregnane X receptor but differentially to hepatocyte nuclear factor-4alpha

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor

21 January 2018

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21 January 2018

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21 January 2018

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Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

21 January 2018

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Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics

21 January 2018

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CYP3A4, CYP2C9 and CYP2B6 expression and ifosfamide turnover in breast cancer tissue microsomes

21 January 2018

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Significant induction of cyclophosphamide and thiotepa metabolism by phenytoin

21 January 2018

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The role of nuclear receptors in pharmacokinetic drug-drug interactions in oncology

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element

21 January 2018

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The transcriptional regulation of the human CYP2C genes

21 January 2018

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The aryl hydrocarbon receptor complex

21 January 2018

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Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

21 January 2018

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21 January 2018

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The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways

21 January 2018

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Identification of a novel mechanism of regulation of Ah (dioxin) receptor function

21 January 2018

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Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor

21 January 2018

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Aryl hydrocarbon receptor degradation-promoting factor (ADPF) and the control of the xenobiotic response

21 January 2018

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Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor

21 January 2018

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The effect of synthetic glucocorticoid, dexamethasone on CYP1A1 inducibility in adult rat and human hepatocytes

21 January 2018

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Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes.

21 January 2018

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Clinical pharmacokinetics of tyrosine kinase inhibitors

21 January 2018

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Interaction of the aryl hydrocarbon receptor ligand 6-methyl-1,3,8-trichlorodibenzofuran with estrogen receptor alpha

21 January 2018

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Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action

21 January 2018

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Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters

21 January 2018

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Estrogen receptor alpha increases basal and cigarette smoke extract-induced expression of CYP1A1 and CYP1B1, but not GSTP1, in normal human bronchial epithelial cells

21 January 2018

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Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

21 January 2018

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Hormonal regulation of CYP1A expression

21 January 2018

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Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.

21 January 2018

1 reference

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The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates

21 January 2018

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Efficient hypoxic activation of the anticancer agent AQ4N by CYP2S1 and CYP2W1.

21 January 2018

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Novel extrahepatic cytochrome P450s

21 January 2018

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Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1).

21 January 2018

1 reference

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A novel promoter element containing multiple overlapping xenobiotic and hypoxia response elements mediates induction of cytochrome P4502S1 by both dioxin and hypoxia

21 January 2018

1 reference

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Profiling cytochrome P450 expression in ovarian cancer: identification of prognostic markers

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Cytochrome p450 profile of colorectal cancer: identification of markers of prognosis

21 January 2018

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A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo.

21 January 2018

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Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription

21 January 2018

1 reference

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

21 January 2018

1 reference

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NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

21 January 2018

1 reference

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Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver

21 January 2018

1 reference

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Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Coordinate regulation of Phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

When NRF2 talks, who's listening?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Role of activator protein-1 in the down-regulation of the human CYP2J2 gene in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Characterization of a c-Jun-responsive module in the 5'-flank of the human CYP2J2 gene that regulates transactivation

21 January 2018

1 reference

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Up-regulation of human CYP2J2 in HepG2 cells by butylated hydroxyanisole is mediated by c-Jun and Nrf2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Cytochrome P450 2J2 promotes the neoplastic phenotype of carcinoma cells and is up-regulated in human tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

The functions of animal microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

MicroRNAs: genomics, biogenesis, mechanism, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Changes in miRNA expression in solid tumors: an miRNA profiling in melanomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

MicroRNA regulates the expression of human cytochrome P450 1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Human CYP2E1 is regulated by miR-378.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Genetic predictors of interindividual variability in hepatic CYP3A4 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

MicroRNAs regulate CYP3A4 expression via direct and indirect targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS00018-010-0600-7

21 January 2018

12 December 2020

Cytochrome P450 pharmacogenetics and cancer.

1 reference

12 December 2020

Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer.

1 reference

12 December 2020

Hypomethylation and hypoexpression of human CYP2E1 gene in lung tumors

1 reference

12 December 2020

Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation

1 reference

12 December 2020

An evidence for regulatory cross-talk between aryl hydrocarbon receptor and glucocorticoid receptor in HepG2 cells.

1 reference

12 December 2020

Xenobiotic induction of cytochrome P450 2B1 (CYP2B1) is mediated by the orphan nuclear receptor constitutive androstane receptor (CAR) and requires steroid co-activator 1 (SRC-1) and the transcription factor Sp1

1 reference

12 December 2020

Relation between inducibility of CYP1A1, GSTM1 and lung cancer in a French population

1 reference

12 December 2020

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver

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12 December 2020

Glutathione transferases and development of new principles to overcome drug resistance

1 reference

12 December 2020

DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter

1 reference

12 December 2020

The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module

1 reference

12 December 2020

Variable contribution of cytochromes P450 2D6, 2C9 and 3A4 to the 4-hydroxylation of tamoxifen by human liver microsomes

1 reference

12 December 2020

Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking.

1 reference

12 December 2020

Cytochrome p450 and glutathione transferase expression in human breast cancer.

1 reference

12 December 2020

Epigenetic inactivation of the dioxin-responsive cytochrome P4501A1 gene in human prostate cancer

1 reference

12 December 2020

Cytochrome P450 CYP1B1 over-expression in primary and metastatic ovarian cancer

1 reference

12 December 2020

The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer - a pilot study

1 reference

12 December 2020

Immunohistochemical localization of cytochrome P450 CYP1B1 in breast cancer with monoclonal antibodies specific for CYP1B1

1 reference

12 December 2020

Induction of CYP2C genes in human hepatocytes in primary culture

1 reference

12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

12 December 2020

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

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12 December 2020

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10.1007/S00018-010-0600-7

Identifiers

DOI

1 reference

23 August 2017

1 reference