Endoplasmic reticulum stress and lipid dysregulation (Q37834712)

24 August 2017

1 reference

title

Endoplasmic reticulum stress and lipid dysregulation (English)

1 reference

24 August 2017

endoplasmic reticulum

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author name string

Stephen M Colgan

series ordinal

1

1 reference

PubMed ID

21288373

24 August 2017

Ali A Hashimi

series ordinal

2

1 reference

PubMed ID

21288373

24 August 2017

Richard C Austin

series ordinal

3

1 reference

24 August 2017

3 February 2011

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Expert Reviews in Molecular Medicine

24 August 2017

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24 August 2017

13

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24 August 2017

e4

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Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

24 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Topology of SREBP cleavage-activating protein, a polytopic membrane protein with a sterol-sensing domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Regulation of the mevalonate pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The proprotein convertases and their implication in sterol and/or lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The SREBP pathway--insights from Insigs and insects

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

From fatty streak to fatty liver: 33 years of joint publications in the JCI

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Cholesterol sensing, trafficking, and esterification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Localization of human acyl-coenzyme A: cholesterol acyltransferase-1 (ACAT-1) in macrophages and in various tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Regulation of sterol synthesis in eukaryotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Plasma membrane cholesterol: a critical determinant of cellular energetics and tubular resistance to attack

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Niemann-Pick type C disease and intracellular cholesterol trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Renal tubular triglyercide accumulation following endotoxic, toxic, and ischemic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Role of cholesterol and lipid organization in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The mevalonate pathway during acute tubular injury: selected determinants and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Acute tubular injury causes dysregulation of cellular cholesterol transport proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Renal cortical cholesterol accumulation is an integral component of the systemic stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Translational control of the sterol-regulatory transcription factor SREBP-1 mRNA in response to serum starvation or ER stress is mediated by an internal ribosome entry site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Proteolytic activation of sterol regulatory element-binding protein induced by cellular stress through depletion of Insig-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

PERK-dependent regulation of lipogenesis during mouse mammary gland development and adipocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Characterization of the stress-inducing effects of homocysteine

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

How IRE1 reacts to ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

A trip to the ER: coping with stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Hyperhomocysteinemia and its role in the development of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Translational control in the endoplasmic reticulum stress response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Role for sterol regulatory element-binding protein in activation of endothelial cells by phospholipid oxidation products

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Scavenger receptors in atherosclerosis: beyond lipid uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Orchestrating the unfolded protein response in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Inhibition of immunoglobulin folding and secretion by dominant negative BiP ATPase mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

ER chaperone functions during normal and stress conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Quality control in the endoplasmic reticulum protein factory

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Glucose trimming and reglucosylation determine glycoprotein association with calnexin in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Quality control in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

The glucose-regulated proteins: stress induction and clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Peptide-binding specificity of the molecular chaperone BiP

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

Intracellular cholesterol transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Dysfunction of the ER chaperone BiP accelerates the renal tubular injury

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Increased proximal tubular cholesterol content: implications for cell injury and "acquired cytoresistance"

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Endoplasmic reticulum stress signaling in disease

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

Intersection of the unfolded protein response and hepatic lipid metabolism

1 reference

https://api.crossref.org/works/10.1017%2FS1462399410001742

7 January 2021

10.1017/S1462399410001742

Identifiers

DOI

1 reference

24 August 2017

1 reference

PubMed ID

21288373