Nucleating actin for invasion (Q37843451)

24 August 2017

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title

Nucleating actin for invasion (English)

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24 August 2017

Robert Grosse

3

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author name string

Alexander Nürnberg

series ordinal

1

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24 August 2017

Thomas Kitzing

series ordinal

2

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24 August 2017

language of work or name

English

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publication date

10 February 2011

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24 August 2017

Nature Reviews Cancer

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24 August 2017

11

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24 August 2017

177-187

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24 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrc3003

24 August 2017

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cites work

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31 March 2020

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EMT, the cytoskeleton, and cancer cell invasion

31 March 2020

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Plasticity of cell migration: a multiscale tuning model

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Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis

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Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis

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Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited

31 March 2020

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The plasticity of cytoskeletal dynamics underlying neoplastic cell migration

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Actin nucleation and elongation factors: mechanisms and interplay

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A nucleator arms race: cellular control of actin assembly

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Rho GTPases: functions and association with cancer

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RHO-GTPases and cancer

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The cofilin pathway in breast cancer invasion and metastasis

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Control of actin filament treadmilling in cell motility

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Atomic model of the actin filament

31 March 2020

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Actin, a central player in cell shape and movement

31 March 2020

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Actin binding proteins: regulation of cytoskeletal microfilaments

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Regulation of actin assembly associated with protrusion and adhesion in cell migration

31 March 2020

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Mammalian Rho GTPases: new insights into their functions from in vivo studies

31 March 2020

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Phylogenetic analysis of the formin homology 2 domain

31 March 2020

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31 March 2020

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Role of formins in actin assembly: nucleation and barbed-end association

31 March 2020

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An actin nucleation mechanism mediated by Bni1 and profilin

31 March 2020

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Molecular details of formin-mediated actin assembly

31 March 2020

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Mechanism and function of formins in the control of actin assembly

31 March 2020

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An integrated genomic analysis of human glioblastoma multiforme

31 March 2020

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Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

31 March 2020

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Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

31 March 2020

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The role of formins in human disease.

31 March 2020

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Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

31 March 2020

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31 March 2020

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Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway

31 March 2020

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mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion

31 March 2020

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The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis

31 March 2020

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The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

31 March 2020

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Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.

31 March 2020

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Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease

31 March 2020

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Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex.

31 March 2020

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High expression of FMNL1 protein in T non-Hodgkin's lymphomas

31 March 2020

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Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies

31 March 2020

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Overexpression of FMNL2 is closely related to metastasis of colorectal cancer

31 March 2020

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Formin-like 2 drives amoeboid invasive cell motility downstream of RhoC

31 March 2020

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Linking actin dynamics and gene transcription to drive cellular motile functions

31 March 2020

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31 March 2020

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SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin

31 March 2020

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The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

31 March 2020

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The Arp2/3 complex branches filament barbed ends: functional antagonism with capping proteins

31 March 2020

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An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branch stability

31 March 2020

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Electron tomography reveals unbranched networks of actin filaments in lamellipodia

31 March 2020

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Arp2/3 complex interactions and actin network turnover in lamellipodia.

31 March 2020

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The structural basis of actin filament branching by the Arp2/3 complex

31 March 2020

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WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

31 March 2020

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Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin

31 March 2020

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Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors.

31 March 2020

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Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors

31 March 2020

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Involvement of Arp2/3 complex in the process of colorectal carcinogenesis.

31 March 2020

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Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer

31 March 2020

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Arpc1b gene is a candidate prediction marker for choroidal malignant melanomas sensitive to radiotherapy

31 March 2020

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Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.

31 March 2020

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Identification and characterization of a novel cytoskeleton-associated pp60src substrate

31 March 2020

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Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP

31 March 2020

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Src phosphorylation of cortactin enhances actin assembly

31 March 2020

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Cortactin regulates cell migration through activation of N-WASP

31 March 2020

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Sequential interaction of actin-related proteins 2 and 3 (Arp2/3) complex with neural Wiscott-Aldrich syndrome protein (N-WASP) and cortactin during branched actin filament network formation

31 March 2020

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N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells

31 March 2020

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Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function

31 March 2020

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Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

31 March 2020

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31 March 2020

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Imaging sites of N-wasp activity in lamellipodia and invadopodia of carcinoma cells.

31 March 2020

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Cortactin promotes cell motility by enhancing lamellipodial persistence

31 March 2020

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Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia

31 March 2020

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WAVE3 promotes cell motility and invasion through the regulation of MMP-1, MMP-3, and MMP-9 expression

31 March 2020

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Multiple regulatory inputs converge on cortactin to control invadopodia biogenesis and extracellular matrix degradation.

31 March 2020

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WAVE1 is associated with invasiveness and growth of prostate cancer cells

31 March 2020

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WAVE3 is associated with invasiveness in prostate cancer cells.

31 March 2020

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Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells

31 March 2020

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Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells.

31 March 2020

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Correlation between liver metastasis of the colocalization of actin-related protein 2 and 3 complex and WAVE2 in colorectal carcinoma

31 March 2020

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Coexpression of Arp2 and WAVE2 predicts poor outcome in invasive breast carcinoma

31 March 2020

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Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer

31 March 2020

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Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray

31 March 2020

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The expression of CFL1 and N-WASP in esophageal squamous cell carcinoma and its correlation with clinicopathological features

31 March 2020

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Cortactin Overexpression Regulates Actin-Related Protein 2/3 Complex Activity, Motility, and Invasion in Carcinomas with Chromosome 11q13 Amplification

31 March 2020

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Cortactin in tumor invasiveness

31 March 2020

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Prognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor status

31 March 2020

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Dominant expression of 85-kDa form of cortactin in colorectal cancer.

31 March 2020

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Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon

31 March 2020

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Overexpression of cortactin is involved in motility and metastasis of hepatocellular carcinoma.

31 March 2020

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Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.

31 March 2020

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Saracatinib Impairs Head and Neck Squamous Cell Carcinoma Invasion by Disrupting Invadopodia Function

31 March 2020

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Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib

31 March 2020

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Cortactin overexpression inhibits ligand-induced down-regulation of the epidermal growth factor receptor

31 March 2020

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Rac activation and inactivation control plasticity of tumor cell movement

31 March 2020

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Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates.

31 March 2020

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DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells

31 March 2020

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The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion

31 March 2020

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WAVE and Arp2/3 jointly inhibit filopodium formation by entering into a complex with mDia2.

31 March 2020

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Cyfip1 is a putative invasion suppressor in epithelial cancers

31 March 2020

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Hyaluronan-CD44 interaction with neural Wiskott-Aldrich syndrome protein (N-WASP) promotes actin polymerization and ErbB2 activation leading to beta-catenin nuclear translocation, transcriptional up-regulation, and cell migration in ovarian tumor ce

31 March 2020

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Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice

31 March 2020

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Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners

31 March 2020

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p53-cofactor JMY is a multifunctional actin nucleation factor

31 March 2020

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A transcription co-factor integrates cell adhesion and motility with the p53 response.

31 March 2020

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Stromal genes discriminate preinvasive from invasive disease, predict outcome, and highlight inflammatory pathways in digestive cancers

31 March 2020

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Ena/VASP: towards resolving a pointed controversy at the barbed end

31 March 2020

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Role of Ena/VASP proteins in homeostasis and disease

31 March 2020

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Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility

31 March 2020

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Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation

31 March 2020

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A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity

31 March 2020

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Filopodia are required for cortical neurite initiation.

31 March 2020

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Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts

31 March 2020

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Negative regulation of fibroblast motility by Ena/VASP proteins

31 March 2020

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cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains

31 March 2020

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Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo.

31 March 2020

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A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis

31 March 2020

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The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors.

31 March 2020

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Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells

31 March 2020

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Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation.

31 March 2020

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Characterization of two classes of small molecule inhibitors of Arp2/3 complex

31 March 2020

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Isoform-selective chemical inhibition of mDia-mediated actin assembly.

31 March 2020

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Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly

31 March 2020

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Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization

31 March 2020

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Migrastatin analogues target fascin to block tumour metastasis

31 March 2020

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Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice

31 March 2020

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Cell motility through plasma membrane blebbing

31 March 2020

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Blebs lead the way: how to migrate without lamellipodia

31 March 2020

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Focal adhesion kinase regulation of N-WASP subcellular localization and function

31 March 2020

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Get to grips: steering local actin dynamics with IQGAPs

31 March 2020

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N-WASP is a putative tumour suppressor in breast cancer cells, in vitro and in vivo, and is associated with clinical outcome in patients with breast cancer

31 March 2020

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Increased expression of Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2 correlated with poor prognosis of hepatocellular carcinoma.

31 March 2020

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Coexpression of actin-related protein 2 and Wiskott-Aldrich syndrome family verproline-homologous protein 2 in adenocarcinoma of the lung

31 March 2020

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EMS1 amplification can occur independently of CCND1 or INT-2 amplification at 11q13 and may identify different phenotypes in primary breast cancer

31 March 2020

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EMS1 gene expression in primary breast cancer: relationship to cyclin D1 and oestrogen receptor expression and patient survival

31 March 2020

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Expression of survivin and cortactin in colorectal adenocarcinoma: association with clinicopathological parameters.

31 March 2020

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Expression of cortactin correlates with a poor prognosis in patients with stages II-III colorectal adenocarcinoma

31 March 2020

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VEGF and cortactin expression are independent predictors of tumor recurrence following curative resection of gastric cancer

31 March 2020

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Differential gene and protein expression in primary gastric carcinomas and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis

31 March 2020

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Association of cortactin and fascin-1 expression in gastric adenocarcinoma: correlation with clinicopathological parameters

31 March 2020

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Cortactin expression predicts poor survival in laryngeal carcinoma

31 March 2020

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Distinctive clinicopathological associations of amplification of the cortactin gene at 11q13 in head and neck squamous cell carcinomas

31 March 2020

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Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma.

31 March 2020

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Markers for assessment of nodal metastasis in laryngeal carcinoma

31 March 2020

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Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression

31 March 2020

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Overexpression of cortactin increases invasion potential in oral squamous cell carcinoma

31 March 2020

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Association of cortactin, fascin-1 and epidermal growth factor receptor (EGFR) expression in ovarian carcinomas: correlation with clinicopathological parameters

31 March 2020

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Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness.

31 March 2020

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Differential expression of VASP in normal lung tissue and lung adenocarcinomas

31 March 2020

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Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression.

31 March 2020

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12 December 2020

Single cell behavior in metastatic primary mammary tumors correlated with gene expression patterns revealed by molecular profiling

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12 December 2020

EVL (Ena/VASP-like) expression is up-regulated in human breast cancer and its relative expression level is correlated with clinical stages.

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12 December 2020

Roles of cortactin in tumor pathogenesis

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12 December 2020

Expression of cyclin D1 and EMS1 in bladder tumours; relationship with chromosome 11q13 amplification

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12 December 2020

Cortactin potentiates bone metastasis of breast cancer cells.

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12 December 2020

Aberrant expression of cortactin and fascin are effective markers for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas.

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12 December 2020

Essential role of neural Wiskott-Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts

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12 December 2020

Identifiers

DOI

10.1038/NRC3003

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Dimensions Publication ID

24 August 2017

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