Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies (Q37853939)

24 August 2017

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title

Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies (English)

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24 August 2017

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3

Emmanuelle Passegué

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24 August 2017

Matthew R Warr

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PubMed ID

21412991

24 August 2017

Eric M Pietras

series ordinal

2

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24 August 2017

15 March 2011

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Wiley interdisciplinary reviews. Systems biology and medicine

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24 August 2017

3

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6

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681-701

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Hematopoiesis: an evolving paradigm for stem cell biology

24 August 2017

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Stem cells and niches: mechanisms that promote stem cell maintenance throughout life

21 January 2018

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Leukemia and hematopoietic stem cells: balancing proliferation and quiescence.

21 January 2018

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Leukaemia stem cells and the evolution of cancer-stem-cell research.

21 January 2018

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Punish the parent not the progeny.

21 January 2018

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Limiting factors in murine hematopoietic stem cell assays.

21 January 2018

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Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.

21 January 2018

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Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior.

21 January 2018

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SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

21 January 2018

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Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood

21 January 2018

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SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity

21 January 2018

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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

21 January 2018

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JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal.

21 January 2018

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Purification and characterization of mouse hematopoietic stem cells

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Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation

21 January 2018

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Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

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Little evidence for developmental plasticity of adult hematopoietic stem cells.

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Long-term propagation of distinct hematopoietic differentiation programs in vivo

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Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair

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CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells

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Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

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Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells

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Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow

21 January 2018

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The adhesion molecule esam1 is a novel hematopoietic stem cell marker

21 January 2018

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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

21 January 2018

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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

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Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice.

21 January 2018

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Differential long-term and multilineage engraftment potential from subfractions of human CD34+ cord blood cells transplanted into NOD/SCID mice

21 January 2018

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Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population.

21 January 2018

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Stem cells and cancer; the polycomb connection

21 January 2018

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The INK4a/ARF network in tumour suppression

21 January 2018

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Tumor suppressive functions of p53

21 January 2018

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

21 January 2018

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Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

21 January 2018

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Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

21 January 2018

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Hematopoietic stem cell ageing is uncoupled from p16 INK4A-mediated senescence.

21 January 2018

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Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

21 January 2018

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Role of polycomb group proteins in stem cell self-renewal and cancer.

21 January 2018

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The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene

21 January 2018

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Enrichment of hematopoietic stem cells with SLAM and LSK markers for the detection of hematopoietic stem cell function in normal and Trp53 null mice

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p53 regulates hematopoietic stem cell quiescence.

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Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates

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Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors

21 January 2018

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Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells

21 January 2018

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A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning.

21 January 2018

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Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

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The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO.

21 January 2018

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PTEN and the PI3-kinase pathway in cancer

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

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TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization

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TOR signaling in growth and metabolism

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Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

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AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

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A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell

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PML targeting eradicates quiescent leukaemia-initiating cells

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Dormant and self-renewing hematopoietic stem cells and their niches

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Uncertainty in the niches that maintain haematopoietic stem cells

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The hematopoietic stem cell niche: low in oxygen but a nice place to be.

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Osteoblastic cells regulate the haematopoietic stem cell niche

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Identification of the haematopoietic stem cell niche and control of the niche size

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Endochondral ossification is required for haematopoietic stem-cell niche formation

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Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture

21 January 2018

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Autocrine transforming growth factor-beta regulation of hematopoiesis: many outcomes that depend on the context

21 January 2018

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Smad4 is critical for self-renewal of hematopoietic stem cells

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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death

21 January 2018

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TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

21 January 2018

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TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro

21 January 2018

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Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

21 January 2018

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Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo

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Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

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TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation.

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Downregulation of JUNB mRNA expression in advanced phase chronic myelogenous leukemia

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TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture

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Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo

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Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.

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Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration

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The Apc(min) mouse has altered hematopoietic stem cell function and provides a model for MPD/MDS.

21 January 2018

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beta-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia

21 January 2018

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

21 January 2018

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Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation

21 January 2018

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A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis

21 January 2018

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The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

21 January 2018

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Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects

21 January 2018

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Indian hedgehog gene transfer augments hematopoietic support of human stromal cells including NOD/SCID-beta2m-/- repopulating cells.

21 January 2018

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Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

21 January 2018

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Indian hedgehog couples chondrogenesis to osteogenesis in endochondral bone development

21 January 2018

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Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

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Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

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Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.

21 January 2018

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Hedgehog signaling is dispensable for adult hematopoietic stem cell function

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Hedgehog signaling is dispensable for adult murine hematopoietic stem cell function and hematopoiesis

21 January 2018

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Imaging hematopoietic precursor division in real time

21 January 2018

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Notch signaling and the bone marrow hematopoietic stem cell niche

21 January 2018

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Notch signaling in embryonic and adult myelopoiesis.

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Notch signalling: a simple pathway becomes complex

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Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

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Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1.

21 January 2018

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RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells

21 January 2018

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The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells

21 January 2018

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Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells

21 January 2018

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Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells.

21 January 2018

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Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

21 January 2018

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Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability.

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Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

21 January 2018

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Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation.

21 January 2018

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Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells

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Notch signaling inhibits the growth of the human chronic myeloid leukemia cell line K562.

21 January 2018

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A wide role for NOTCH1 signaling in acute leukemia

21 January 2018

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Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells

21 January 2018

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21 January 2018

It's T-ALL about Notch

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Multilevel targeting of hematopoietic stem cell self-renewal, differentiation and apoptosis for leukemia therapy

21 January 2018

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DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

21 January 2018

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Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

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Dysregulated gene expression networks in human acute myelogenous leukemia stem cells

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Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells

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Awakening dormant haematopoietic stem cells

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/WSBM.145

1 reference

24 August 2017

1 reference

PubMed ID

21412991