Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease (Q37893571)

24 August 2017

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title

Ca2+ dysfunction in neurodegenerative disorders: Alzheimer's disease (English)

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24 August 2017

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2

Ernesto Carafoli

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24 August 2017

Laura Fedrizzi

1

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24 August 2017

1 May 2011

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24 August 2017

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24 August 2017

37

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24 August 2017

3

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24 August 2017

189-196

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Alzheimer's disease: A prion protein connection.

24 August 2017

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Calcium signaling and amyloid toxicity in Alzheimer disease

21 January 2018

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

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Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production

21 January 2018

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Synaptotoxicity of Alzheimer beta amyloid can be explained by its membrane perforating property

21 January 2018

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Hypothesis on the regulation of cytosol calcium concentration and the aging brain

21 January 2018

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Lipid membranes and beta-amyloid: a harmful connection

21 January 2018

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Amyloid beta oligomers (A beta(1-42) globulomer) suppress spontaneous synaptic activity by inhibition of P/Q-type calcium currents.

21 January 2018

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Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice.

21 January 2018

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

21 January 2018

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NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice

21 January 2018

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No association between CALHM1 and Alzheimer's disease risk

21 January 2018

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A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

21 January 2018

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Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase

21 January 2018

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Structural investigation of the C-terminal catalytic fragment of presenilin 1

21 January 2018

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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

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Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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A familial Alzheimer's disease locus on chromosome 1.

21 January 2018

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

21 January 2018

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Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules

21 January 2018

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Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

21 January 2018

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A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy?

21 January 2018

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A nine-transmembrane domain topology for presenilin 1

21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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Molecular characterization and temporal expression profiling of presenilins in the developing porcine brain

21 January 2018

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Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process

21 January 2018

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DREAM is a Ca2+-regulated transcriptional repressor

21 January 2018

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Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling

21 January 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

21 January 2018

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gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

21 January 2018

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Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases

21 January 2018

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gamma-secretases: from cell biology to therapeutic strategies

21 January 2018

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The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein

21 January 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

21 January 2018

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Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

21 January 2018

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Presenilins: how much more than γ-secretase?!

21 January 2018

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Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease

21 January 2018

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Modulation of A-type potassium channels by a family of calcium sensors

21 January 2018

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Calsenilin reverses presenilin-mediated enhancement of calcium signaling

21 January 2018

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Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease

21 January 2018

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Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease

21 January 2018

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Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4,5-trisphosphate-mediated calcium signals

21 January 2018

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Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

21 January 2018

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Subcellular mechanisms of presenilin-mediated enhancement of calcium signaling

21 January 2018

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The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores

21 January 2018

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Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

21 January 2018

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

21 January 2018

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Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating.

21 January 2018

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Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

21 January 2018

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Mechanisms of mitochondrial dysfunction and energy deficiency in Alzheimer's disease

21 January 2018

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Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

21 January 2018

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Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

21 January 2018

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Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria

21 January 2018

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Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria

21 January 2018

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Calcium hypothesis of Alzheimer's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/BIOF.157

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release_as5lfqgldza7npmux4nqukozy4

24 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/as5lfqgldza7npmux4nqukozy4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

21698698

1 reference

PubMed ID

21698698