Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases (Q33852318)

29 July 2017

title

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases (English)

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Peter Henry St George-Hyslop

29 July 2017

object named as

Peter St George-Hyslop

18

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author name string

Peter Mastrangelo

1

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M Azhar Chishti

3

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Stephen D Schmidt

4

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Yongjun Gu

5

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Jing Yang

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Matthew J Mazzella

7

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Janaky Coomaraswamy

8

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Patrick Horne

9

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Bob Strome

10

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Heather Pelly

11

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Georges Levesque

12

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Chris Ebeling

13

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Ying Jiang

14

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Ralph A Nixon

15

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Richard Rozmahel

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Paul E Fraser

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George A Carlson

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David Westaway

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language of work or name

English

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publication date

10 June 2005

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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volume

102

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issue

25

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page(s)

8972-8977

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describes a project that uses

29 July 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1149500/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

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APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

5 July 2018

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

5 July 2018

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Identification of distinct gamma-secretase complexes with different APH-1 variants

5 July 2018

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The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

5 July 2018

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In vivo reduction of amyloid-beta by a mutant copper transporter

5 July 2018

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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

5 July 2018

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Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

5 July 2018

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Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

5 July 2018

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5 July 2018

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APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

5 July 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

5 July 2018

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Calpain activity regulates the cell surface distribution of amyloid precursor protein. Inhibition of calpains enhances endosomal generation of beta-cleaved C-terminal APP fragments

5 July 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

5 July 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

5 July 2018

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5 July 2018

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

5 July 2018

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A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

5 July 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

5 July 2018

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Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

5 July 2018

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5 July 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

5 July 2018

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0500940102

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21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0500940102

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21 January 2018

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https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0500940102

Turnover of amyloid beta-protein in mouse brain and acute reduction of its level by phorbol ester.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1149500

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15951428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15951428

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0500940102

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference