Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase (Q39627819)

13 September 2017

Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase (English)

1 reference

13 September 2017

transmembrane protein

0 references

author

Taisuke Tomita

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

author name string

Shizuka Takagi

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

Aya Tominaga

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

Chihiro Sato

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

Takeshi Iwatsubo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

language of work or name

English

0 references

publication date

1 November 2010

1 reference

13 September 2017

Journal of Neuroscience

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

volume

30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

issue

47

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

page(s)

15943-15950

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

Membrane topology of Alzheimer's disease-related presenilin 1. Evidence for the existence of a molecular species with a seven membrane-spanning and one membrane-embedded structure

15 May 2020

cites work

1 reference

12 December 2020

C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin

1 reference

12 December 2020

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

1 reference

12 December 2020

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

12 December 2020

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

12 December 2020

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

1 reference

12 December 2020

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

12 December 2020

The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

1 reference

12 December 2020

The kamikaze approach to membrane transport

1 reference

12 December 2020

Determining the dimensions of the drug-binding domain of human P-glycoprotein using thiol cross-linking compounds as molecular rulers

1 reference

12 December 2020

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

12 December 2020

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

12 December 2020

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

12 December 2020

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

12 December 2020

The role of presenilin cofactors in the gamma-secretase complex

1 reference

12 December 2020

Designed Helical Peptides Inhibit an Intramembrane Protease

1 reference

12 December 2020

Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics

1 reference

12 December 2020

The orientation and molecular movement of a k(+) channel voltage-sensing domain.

1 reference

12 December 2020

The inner world of cell adhesion: integrin cytoplasmic domains

1 reference

12 December 2020

Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity

1 reference

12 December 2020

Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

1 reference

12 December 2020

Intramembrane proteolysis: theme and variations.

1 reference

12 December 2020

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

1 reference

12 December 2020

Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity

1 reference

12 December 2020

The initial substrate-binding site of gamma-secretase is located on presenilin near the active site

1 reference

12 December 2020

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity

1 reference

12 December 2020

Transport mechanism of the sarcoplasmic reticulum Ca2+ -ATPase pump

1 reference

12 December 2020

Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1

1 reference

12 December 2020

Three-dimensional structure of the γ-secretase complex

1 reference

12 December 2020

Dynamic behavior of fully solvated beta2-adrenergic receptor, embedded in the membrane with bound agonist or antagonist.

1 reference

12 December 2020

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

1 reference

12 December 2020

Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores

1 reference

12 December 2020

Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking

1 reference

12 December 2020

Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex.

1 reference

12 December 2020

Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.

1 reference

12 December 2020

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

1 reference

12 December 2020

Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate

1 reference

12 December 2020

Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

1 reference

12 December 2020

Core principles of intramembrane proteolysis: comparison of rhomboid and site-2 family proteases

1 reference

12 December 2020

Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase

1 reference

12 December 2020

The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.

1 reference

12 December 2020

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements

1 reference

12 December 2020

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

1 reference

12 December 2020

Secretase inhibitors and modulators for Alzheimer's disease treatment

1 reference

12 December 2020

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

1 reference

12 December 2020

Bacterial chemoreceptors: providing enhanced features to two-component signaling

1 reference

12 December 2020

The secretases: enzymes with therapeutic potential in Alzheimer disease

1 reference

12 December 2020

Proline kinks in transmembrane alpha-helices

1 reference

12 December 2020

Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

1 reference

12 December 2020

Structural investigation of the C-terminal catalytic fragment of presenilin 1

1 reference

12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

12 December 2020

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

1 reference

12 December 2020

Membrane topology of the C. elegans SEL-12 presenilin

1 reference

12 December 2020

Protein topology of presenilin 1

1 reference

12 December 2020

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

1 reference

12 December 2020

Evidence for a six-transmembrane domain structure of presenilin 1.

1 reference

12 December 2020

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

1 reference

12 December 2020

Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

1 reference

12 December 2020

Substituted-cysteine accessibility method

1 reference

12 December 2020

10.1523/JNEUROSCI.3318-10.2010

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6633739&resulttype=core&format=json

15 May 2020

1 reference