Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases (Q37922607)

25 August 2017

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title

Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases (English)

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25 August 2017

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2

Vladimir N Uversky

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25 August 2017

Leonid Breydo

1

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25 August 2017

25 August 2011

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25 August 2017

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25 August 2017

3

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25 August 2017

11

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25 August 2017

1163-1180

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Protein folding and misfolding

25 August 2017

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https://api.crossref.org/works/10.1039%2FC1MT00106J

Amyloidogenesis of natively unfolded proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MT00106J

Flexible nets of malleable guardians: intrinsically disordered chaperones in neurodegenerative diseases

21 January 2018

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https://api.crossref.org/works/10.1039%2FC1MT00106J

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D(2) concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsic disorder in proteins associated with neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alpha-synuclein misfolding and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Mysterious oligomerization of the amyloidogenic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Kinetic partitioning of protein folding and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Rationalization of the effects of mutations on peptide and protein aggregation rates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The molecular basis of amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Molecular structure of a fibrillar Alzheimer's A beta fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

De novo designed peptide-based amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

A comparative study of the relationship between protein structure and beta-aggregation in globular and intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prediction of aggregation rate and aggregation-prone segments in polypeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsically disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Natively unfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Protein folding revisited. A polypeptide chain at the folding ? misfolding ? nonfolding cross-roads: which way to go?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

"Partly folded" state, a new equilibrium state of protein molecules: four-state guanidinium chloride-induced unfolding of beta-lactamase at low temperature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Sequence complexity of disordered protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsic disorder and functional proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

NORSp: Predictions of long regions without regular secondary structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Protein disorder prediction: implications for structural proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

GlobPlot: Exploring protein sequences for globularity and disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prediction of disordered regions in proteins from position specific score matrices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The DISOPRED server for the prediction of protein disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prediction and Functional Analysis of Native Disorder in Proteins from the Three Kingdoms of Life

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Predicting intrinsic disorder in proteins: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Comparing and combining predictors of mostly disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsic disorder and protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Functional anthology of intrinsic disorder. 2. Cellular components, domains, technical terms, developmental processes, and coding sequence diversities correlated with long disordered regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Flexible nets. The roles of intrinsic disorder in protein interaction networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsic disorder in cell-signaling and cancer-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The protein trinity--linking function and disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Natively unfolded proteins: a point where biology waits for physics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

What does it mean to be natively unfolded?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsically unstructured proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Insights into the structure and dynamics of unfolded proteins from nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsically unstructured proteins and their functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Multitude of binding modes attainable by intrinsically disordered proteins: a portrait gallery of disorder-based complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

DisProt: the Database of Disordered Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Shattuck lecture--neurodegenerative diseases and prions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Polyglutamine diseases: protein cleavage and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

PONDR-FIT: a meta-predictor of intrinsically disordered amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Stabilization of proteins by low molecular weight multi-ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Protein aggregation: folding aggregates, inclusion bodies and amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Conformational constraints for amyloid fibrillation: the importance of being unfolded

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Dementia. Age-dependent incidence, prevalence, and mortality in the old old.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural classification of toxic amyloid oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Identification and characterization of key kinetic intermediates in amyloid beta-protein fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Zinc in the physiology and pathology of the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Interactions of Zn(II) and Cu(II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Role of metal dyshomeostasis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper, iron and zinc in Alzheimer's disease senile plaques.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper in the brain and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper(II) binding to amyloid-beta fibrils of Alzheimer's disease reveals a picomolar affinity: stoichiometry and coordination geometry are independent of Abeta oligomeric form

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-beta peptide near physiological pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Importance of dynamical processes in the coordination chemistry and redox conversion of copper amyloid-beta complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The amyloid-beta peptide of Alzheimer's disease binds Cu(I) in a linear bis-his coordination environment: insight into a possible neuroprotective mechanism for the amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Affinity of Cu+ for the copper-binding domain of the amyloid-β peptide of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Distinct effects of Zn2+, Cu2+, Fe3+, and Al3+ on amyloid-beta stability, oligomerization, and aggregation: amyloid-beta destabilization promotes annular protofibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The galvanization of beta-amyloid in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Molecular-level examination of Cu2+ binding structure for amyloid fibrils of 40-residue Alzheimer's β by solid-state NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Generation of soluble oligomeric beta-amyloid species via copper catalyzed oxidation with implications for Alzheimer's disease: a DFT study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

NMR studies of the Zn2+ interactions with rat and human beta-amyloid (1-28) peptides in water-micelle environment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Bioinorganic chemistry of copper and zinc ions coordinated to amyloid-beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Rapid induction of Alzheimer A beta amyloid formation by zinc.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Zinc-amyloid beta interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Aluminum-triggered structural modifications and aggregation of beta-amyloids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Increased APLP1 expression and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganese, monoamine metabolite levels at birth, and child psychomotor development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Neuropsychological profiles of manganese neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganese exposure: neuropsychological and neurological symptoms and effects in welders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Effects of chronic manganese exposure on working memory in non-human primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Molecular targets of lead in brain neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Past adult lead exposure is linked to neurodegeneration measured by brain MRI

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

A protein factor essential for microtubule assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Brief update on different roles of tau in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The importance of neuritic plaques and tangles to the development and evolution of AD

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Granular tau oligomers as intermediates of tau filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Spectroscopic approaches to the conformation of tau protein in solution and in paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Automatic assignment of the intrinsically disordered protein Tau with 441-residues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Preparation and characterization of neurotoxic tau oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Triggers of full-length tau aggregation: a role for partially folded intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Tau protein becomes long and stiff upon phosphorylation: correlation between paracrystalline structure and degree of phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural and functional implications of tau hyperphosphorylation: information from phosphorylation-mimicking mutated tau proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural characterization of binding of Cu(II) to tau protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Low micromolar zinc accelerates the fibrillization of human tau via bridging of Cys-291 and Cys-322.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Mercury(II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule-binding domain: Coordination and conformational transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alpha-synuclein and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Part II: alpha-synuclein and its molecular pathophysiological role in neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

A protein-chameleon: conformational plasticity of alpha-synuclein, a disordered protein involved in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The aggregation and fibrillation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alpha-synuclein is a cellular ferrireductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Biophysics of Parkinson's disease: structure and aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Correlation of amyloid fibril beta-structure with the unfolded state of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Aluminum-containing antacids as a cause of idiopathic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Occupational exposures to metals as risk factors for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Heavy metals and the etiology of Parkinson's disease and other movement disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

21 January 2018

Metals and neuroscience.

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Metalloproteomics and metal toxicology of α-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Metals accelerate the formation and direct the structure of amyloid fibrils of NAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Interplay between cytosolic dopamine, calcium, and alpha-synuclein causes selective death of substantia nigra neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Ca2+ binding to alpha-synuclein regulates ligand binding and oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Calcium(II) selectively induces alpha-synuclein annular oligomers via interaction with the C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Raised calcium promotes α-synuclein aggregate formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Calcium-triggered membrane interaction of the alpha-synuclein acidic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

NMR mapping of copper binding sites in alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural characterization of copper(II) binding to alpha-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Coordination features and affinity of the Cu²+ site in the α-synuclein protein of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper(II) binding to alpha-synuclein, the Parkinson's protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural characterization of a high affinity mononuclear site in the copper(II)-α-synuclein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Identification of the minimal copper(II)-binding alpha-synuclein sequence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Metal binding to alpha-synuclein peptides and its contribution to toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Conformational equilibria in monomeric alpha-synuclein at the single-molecule level

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Unique copper-induced oligomers mediate alpha-synuclein toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Iron and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Potential role of alpha-synuclein and metallothionein in lead-induced inclusion body formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Magnesium deficiency over generations in rats with special references to the pathogenesis of the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Dependence of alpha-synuclein aggregate morphology on solution conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Magnesium exerts both preventive and ameliorating effects in an in vitro rat Parkinson disease model involving 1-methyl-4-phenylpyridinium (MPP+) toxicity in dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganism and idiopathic parkinsonism: similarities and differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Parkinsonism: a clinical marker of exposure to neurotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

alpha-Synuclein selectively increases manganese-induced viability loss in SK-N-MC neuroblastoma cells expressing the human dopamine transporter.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Mercury neurotoxicity: mechanisms of blood-brain barrier transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Accumulation of methylmercury and inorganic mercury in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Impact of dietary exposure to food contaminants on the risk of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

SKN-1/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Parkinson's disease, macular degeneration and cutaneous signs of mercury toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural changes in alpha-synuclein affect its chaperone-like activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Site-specific interactions of Cu(II) with alpha and beta-synuclein: bridging the molecular gap between metal binding and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Identification of the Cu2+ binding sites in the N-terminal domain of the prion protein by EPR and CD spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Creutzfeldt-Jakob disease: Patterns of worldwide occurrence and the significance of familial and sporadic clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

21 January 2018

Prion Protein Biology

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prion hypothesis: the end of the controversy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Molecular features of the copper binding sites in the octarepeat domain of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Three-dimensional structures of prion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Propagation of prions with artificial properties in transgenic mice expressing chimeric PrP genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Folding intermediates of the prion protein stabilized by hydrostatic pressure and low temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Pathway complexity of prion protein assembly into amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper coordination in the full-length, recombinant prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Evaluation of copper2+ affinities for the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper binding extrinsic to the octarepeat region in the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper stimulates endocytosis of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Exacerbation of copper toxicity in primary neuronal cultures depleted of cellular glutathione.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper redox cycling in the prion protein depends critically on binding mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Neuroprotective effects of the cellular prion protein in autoimmune optic neuritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper induces conformational changes in the N-terminal part of cell-surface PrPC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Conformational change in full-length mouse prion: a site-directed spin-labeling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper binding to the octarepeats of the prion protein. Affinity, specificity, folding, and cooperativity: insights from circular dichroism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper(II) inhibits in vitro conversion of prion protein into amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Preferential Cu2+ coordination by His96 and His111 induces beta-sheet formation in the unstructured amyloidogenic region of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Effect of copper and manganese on the de novo generation of protease-resistant prion protein in yeast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper chelation delays the onset of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Role of copper and manganese in prion disease progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Location and properties of metal-binding sites on the human prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Stimulation-induced uptake and release of zinc in hippocampal slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Release of endogenous Zn2+ from brain tissue during activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The prion protein is a combined zinc and copper binding protein: Zn2+ alters the distribution of Cu2+ coordination modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Thermodynamic and voltammetric characterization of the metal binding to the prion protein: insights into pH dependence and redox chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Prion protein fate governed by metal binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Consequences of manganese replacement of copper for prion protein function and proteinase resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganese enhances prion protein survival in model soils and increases prion infectivity to cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Single particle analysis of manganese-induced prion protein aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Trinucleotide repeats: mechanisms and pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Fourteen and counting: unraveling trinucleotide repeat diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Glutamine repeats and inherited neurodegenerative diseases: molecular aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The spinocerebellar ataxia type 1 protein, ataxin-1, has RNA-binding activity that is inversely affected by the length of its polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Evidence for a recruitment and sequestration mechanism in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Protein aggregation and pathogenesis of Huntington's disease: mechanisms and correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Amyloid-like features of polyglutamine aggregates and their assembly kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Destabilization of a non-pathological variant of ataxin-3 results in fibrillogenesis via a partially folded intermediate: a model for misfolding in polyglutamine disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Huntingtin interacts with a family of WW domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

The transition metals copper and iron in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Mechanisms of copper ion mediated Huntington's disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Structural modeling of ataxin-3 reveals distant homology to adaptins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Domain architecture of the polyglutamine protein ataxin-3: a globular domain followed by a flexible tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Interaction of selected divalent metal ions with human ataxin-3 Q36.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Familial cerebral amyloid angiopathy with nonneuritic amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

A stop-codon mutation in the BRI gene associated with familial British dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Systemic amyloid deposits in familial British dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

pH-Dependent Amyloid and Protofibril Formation by the ABri Peptide of Familial British Dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Thermodynamics imprinting reveals differential binding of metals to α-synuclein: Relevance to parkinson’s disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Compact conformations of α-synuclein induced by alcohols and copper

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Copper- and iron-induced differential fibril formation in α-synuclein: TEM study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Strain-specific prion-protein conformation determined by metal ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous β-sheet helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

Cu2+Binding Modes of Recombinant α-Synuclein − Insights from EPR Spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC1MT00106J

21 January 2018

Identifiers

DOI

10.1039/C1MT00106J

1 reference

25 August 2017

1 reference

PubMed ID

21869995