More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance (Q37942059)

25 August 2017

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title

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance (English)

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25 August 2017

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1

Jiri Lukas

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Jiří Bártek

series ordinal

3

object named as

Jiri Bartek

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Claudia Lukas

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Claudia Lukas

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2

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publication date

3 October 2011

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25 August 2017

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25 August 2017

13

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25 August 2017

10

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25 August 2017

1161-1169

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https://scigraph.springernature.com/pub.10.1038/ncb2344

25 August 2017

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cites work

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

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12 December 2020

PARP-3 and APLF function together to accelerate nonhomologous end-joining

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12 December 2020

KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response.

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12 December 2020

DNA damage triggers nucleotide excision repair-dependent monoubiquitylation of histone H2A

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12 December 2020

MDC1: The art of keeping things in focus

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12 December 2020

RAD18 transmits DNA damage signalling to elicit homologous recombination repair

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12 December 2020

Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair.

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12 December 2020

WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity

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12 December 2020

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

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12 December 2020

Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control

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12 December 2020

Positional stability of single double-strand breaks in mammalian cells

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12 December 2020

BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery

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12 December 2020

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells

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12 December 2020

DNA-damage response and repair activities at uncapped telomeres depend on RNF8

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12 December 2020

Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones

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12 December 2020

A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency

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12 December 2020

MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage

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12 December 2020

HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.

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12 December 2020

CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.

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12 December 2020

PARP1 ADP-ribosylates lysine residues of the core histone tails

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12 December 2020

Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals

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12 December 2020

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

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12 December 2020

Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair

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12 December 2020

DNA damage, homology-directed repair, and DNA methylation

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12 December 2020

53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

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12 December 2020

Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia

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12 December 2020

Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

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12 December 2020

Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription.

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12 December 2020

Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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12 December 2020

53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination

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12 December 2020

Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

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12 December 2020

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks

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12 December 2020

Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

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12 December 2020

The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection

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12 December 2020

RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1.

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12 December 2020

The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair

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12 December 2020

MDC1 collaborates with TopBP1 in DNA replication checkpoint control

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12 December 2020

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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12 December 2020

Assembly of multiprotein complexes that control genome function

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12 December 2020

Replication stress induces 53BP1-containing OPT domains in G1 cells

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12 December 2020

The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage

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12 December 2020

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

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12 December 2020

BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response

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12 December 2020

HP1alpha recruitment to DNA damage by p150CAF-1 promotes homologous recombination repair

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12 December 2020

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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12 December 2020

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

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12 December 2020

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

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12 December 2020

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

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12 December 2020

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

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12 December 2020

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis.

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12 December 2020

Systematic protein location mapping reveals five principal chromatin types in Drosophila cells

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12 December 2020

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

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12 December 2020

BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair

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12 December 2020

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

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12 December 2020

DNA repair factor APLF is a histone chaperone

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12 December 2020

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

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12 December 2020

The Smc5-Smc6 complex and SUMO modification of Rad52 regulates recombinational repair at the ribosomal gene locus.

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12 December 2020

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome

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12 December 2020

DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics

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12 December 2020

The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage

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12 December 2020

Epigenetic instability due to defective replication of structured DNA.

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12 December 2020

High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.

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12 December 2020

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

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12 December 2020

The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

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12 December 2020

Chfr and RNF8 synergistically regulate ATM activation

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12 December 2020

Chromatin challenges during DNA replication and repair

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12 December 2020

Histone methyltransferase Dot1 and Rad9 inhibit single-stranded DNA accumulation at DSBs and uncapped telomeres

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12 December 2020

Deficiency in Bre1 impairs homologous recombination repair and cell cycle checkpoint response to radiation damage in mammalian cells

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12 December 2020

Histone ubiquitination associates with BRCA1-dependent DNA damage response

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12 December 2020

Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks

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12 December 2020

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks

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12 December 2020

APLF (C2orf13) is a novel human protein involved in the cellular response to chromosomal DNA strand breaks

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12 December 2020

A guide to super-resolution fluorescence microscopy

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12 December 2020

Regulation of homologous recombination by RNF20-dependent H2B ubiquitination.

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12 December 2020

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

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12 December 2020

Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage

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12 December 2020

Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1

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12 December 2020

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

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12 December 2020

Human Xip1 (C2orf13) is a novel regulator of cellular responses to DNA strand breaks

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12 December 2020

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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12 December 2020

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

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12 December 2020

RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

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12 December 2020

Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions

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12 December 2020

HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes

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12 December 2020

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

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12 December 2020

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

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12 December 2020

A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

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12 December 2020

Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler

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12 December 2020

Global chromatin compaction limits the strength of the DNA damage response

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12 December 2020

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1

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12 December 2020

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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12 December 2020

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

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12 December 2020

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

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12 December 2020

The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

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12 December 2020

Heterochromatin protein 1 is recruited to various types of DNA damage.

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12 December 2020

Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4

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12 December 2020

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

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12 December 2020

The DNA Damage Response: Making It Safe to Play with Knives

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12 December 2020

A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses

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12 December 2020

A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage

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12 December 2020

Chromatin dynamics and the repair of DNA double strand breaks

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12 December 2020

Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage

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12 December 2020

Identifiers

DOI

10.1038/NCB2344

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25 August 2017

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PubMed ID

21968989