Exploring HCN channels as novel drug targets (Q37957655)

25 August 2017

Exploring HCN channels as novel drug targets (English)

1 reference

25 August 2017

2

Martin Biel

1 reference

25 August 2017

Otilia Postea

1

1 reference

25 August 2017

18 November 2011

1 reference

Nature Reviews Drug Discovery

25 August 2017

1 reference

25 August 2017

10

1 reference

25 August 2017

903-914

1 reference

25 August 2017

12

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd3576

25 August 2017

0 references

cites work

Hyperpolarization-activated cation channels: from genes to function

1 reference

Hyperpolarization-activated cation currents: from molecules to physiological function

21 January 2018

1 reference

Physiology and pharmacology of the cardiac pacemaker ("funny") current

21 January 2018

1 reference

HCN channels in behavior and neurological disease: too hyper or not active enough?

21 January 2018

1 reference

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and pain

21 January 2018

1 reference

How does adrenaline accelerate the heart?

21 January 2018

1 reference

Voltage-clamp analysis of muscarinic excitation in hippocampal neurons

21 January 2018

1 reference

Queer current and pacemaker: the hyperpolarization-activated cation current in neurons

21 January 2018

1 reference

Overview of molecular relationships in the voltage-gated ion channel superfamily.

21 January 2018

1 reference

Molecular identification of a hyperpolarization-activated channel in sea urchin sperm

21 January 2018

1 reference

Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatrial node

21 January 2018

1 reference

Identification of a cyclic nucleotide- and voltage-activated ion channel from insect antennae

21 January 2018

1 reference

A family of hyperpolarization-activated mammalian cation channels

21 January 2018

1 reference

Two pacemaker channels from human heart with profoundly different activation kinetics

21 January 2018

1 reference

Molecular cloning of a putative voltage- and cyclic nucleotide-gated ion channel present in the antennae and eyes of Drosophila melanogaster

21 January 2018

1 reference

Molecular characterization of a slowly gating human hyperpolarization-activated channel predominantly expressed in thalamus, heart, and testis

21 January 2018

1 reference

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain

21 January 2018

1 reference

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels

21 January 2018

1 reference

Distribution and prevalence of hyperpolarization-activated cation channel (HCN) mRNA expression in cardiac tissues

21 January 2018

1 reference

Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages.

21 January 2018

1 reference

Structural basis for modulation and agonist specificity of HCN pacemaker channels

21 January 2018

1 reference

Structural Basis for the cAMP-dependent Gating in the Human HCN4 Channel

21 January 2018

1 reference

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.

21 January 2018

1 reference

Molecular mechanism of cAMP modulation of HCN pacemaker channels.

21 January 2018

1 reference

The murine HCN3 gene encodes a hyperpolarization-activated cation channel with slow kinetics and unique response to cyclic nucleotides

21 January 2018

1 reference

Functional heteromerization of HCN1 and HCN2 pacemaker channels

21 January 2018

1 reference

Differential distribution of four hyperpolarization-activated cation channels in mouse brain

21 January 2018

1 reference

Immunohistochemical localization of Ih channel subunits, HCN1-4, in the rat brain

21 January 2018

1 reference

HCN3 contributes to the ventricular action potential waveform in the murine heart

21 January 2018

1 reference

HCN channels are expressed differentially in retinal bipolar cells and concentrated at synaptic terminals

21 January 2018

1 reference

Inflammation-induced increase in hyperpolarization-activated, cyclic nucleotide-gated channel protein in trigeminal ganglion neurons and the effect of buprenorphine

21 January 2018

1 reference

The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

21 January 2018

1 reference

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

21 January 2018

1 reference

Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

21 January 2018

1 reference

Postnatal maturation of the hyperpolarization-activated cation current, I(h), in trigeminal sensory neurons.

21 January 2018

1 reference

21 January 2018

1 reference

Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus

21 January 2018

1 reference

Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation

21 January 2018

1 reference

TRIP8b splice variants form a family of auxiliary subunits that regulate gating and trafficking of HCN channels in the brain.

21 January 2018

1 reference

Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.

21 January 2018

1 reference

TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons

21 January 2018

1 reference

21 January 2018

1 reference

K+ channel regulator KCR1 suppresses heart rhythm by modulating the pacemaker current If.

21 January 2018

1 reference

Interaction of the pacemaker channel HCN1 with filamin A.

21 January 2018

1 reference

Hyperpolarization-activated, cyclic nucleotide-gated HCN2 cation channel forms a protein assembly with multiple neuronal scaffold proteins in distinct modes of protein-protein interaction

21 January 2018

1 reference

Localization of f-channels to caveolae mediates specific beta2-adrenergic receptor modulation of rate in sinoatrial myocytes

21 January 2018

1 reference

Regulation of gating and rundown of HCN hyperpolarization-activated channels by exogenous and endogenous PIP2

21 January 2018

1 reference

Pacemaking by HCN channels requires interaction with phosphoinositides.

21 January 2018

1 reference

A single histidine residue determines the pH sensitivity of the pacemaker channel HCN2.

21 January 2018

1 reference

Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli

21 January 2018

1 reference

An arginine residue in the pore region is a key determinant of chloride dependence in cardiac pacemaker channels

21 January 2018

1 reference

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

21 January 2018

1 reference

Constitutively active Src tyrosine kinase changes gating of HCN4 channels through direct binding to the channel proteins

21 January 2018

1 reference

Modulation of h-channels in hippocampal pyramidal neurons by p38 mitogen-activated protein kinase.

21 January 2018

1 reference

Downregulation of dendritic HCN channel gating in epilepsy is mediated by altered phosphorylation signaling

21 January 2018

1 reference

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel

21 January 2018

1 reference

HCN-related channelopathies.

21 January 2018

1 reference

The role of the funny current in pacemaker activity.

21 January 2018

1 reference

Characteristics of HCN channels and their participation in neuropathic pain

21 January 2018

1 reference

The Yin and Yang of the H-Channel and Its Role in Epilepsy

21 January 2018

1 reference

Pacemaker channel dysfunction in a patient with sinus node disease

21 January 2018

1 reference

Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia

21 January 2018

1 reference

Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel

21 January 2018

1 reference

Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia

21 January 2018

1 reference

cAMP sensitivity of HCN pacemaker channels determines basal heart rate but is not critical for autonomic rate control

21 January 2018

1 reference

A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.

21 January 2018

1 reference

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.

21 January 2018

1 reference

HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice

21 January 2018

1 reference

Tamoxifen-inducible gene deletion in the cardiac conduction system

21 January 2018

1 reference

I(f) in non-pacemaker cells: role and pharmacological implications.

21 January 2018

1 reference

Genesis and regulation of the heart automaticity.

21 January 2018

1 reference

Molecular basis of funny current (If) in normal and failing human heart.

21 January 2018

1 reference

Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks

21 January 2018

1 reference

Differential distribution and function of hyperpolarization-activated channels in sensory neurons and mechanosensitive fibers.

21 January 2018

1 reference

Double Trouble? Potential for Hyperexcitability Following Both Channelopathic up- and Downregulation of I(h) in Epilepsy

21 January 2018

1 reference

Influence of heart rate on mortality in a French population: role of age, gender, and blood pressure.

21 January 2018

1 reference

Sinus tachyarrhythmias and the specific bradycardic agents: a marriage made in heaven?

21 January 2018

1 reference

Drug insight: If inhibitors as specific heart-rate-reducing agents

21 January 2018

1 reference

Rest heart rate and life expectancy

21 January 2018

1 reference

Heart rate reduction after heart transplantation with beta-blocker versus the selective If channel antagonist ivabradine.

21 January 2018

1 reference

Molecular regulation and pharmacology of pacemaker channels

21 January 2018

1 reference

Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine

21 January 2018

1 reference

Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.

21 January 2018

1 reference

Ivabradine: beyond heart rate control

21 January 2018

1 reference

A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction

21 January 2018

1 reference

Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial

21 January 2018

1 reference

Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial

21 January 2018

1 reference

Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study

21 January 2018

1 reference

Design, synthesis, and preliminary biological evaluation of new isoform-selective f-current blockers

21 January 2018

1 reference

Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells

21 January 2018

1 reference

Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease.

21 January 2018

1 reference

Ivabradine: pharmacodynamic aspects of its clinical use.

21 January 2018

1 reference

Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors

21 January 2018

1 reference

Cellular mechanisms underlying the pharmacological induction of phosphenes

21 January 2018

1 reference

I f inhibition with ivabradine : electrophysiological effects and safety

21 January 2018

1 reference

Direct inhibition of cardiac hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by clonidine

21 January 2018

1 reference

Loss of dendritic HCN1 subunits enhances cortical excitability and epileptogenesis

21 January 2018

1 reference

Increased seizure severity and seizure-related death in mice lacking HCN1 channels

21 January 2018

1 reference

Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons

21 January 2018

1 reference

Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy

21 January 2018

1 reference

Augmented currents of an HCN2 variant in patients with febrile seizure syndromes

21 January 2018

1 reference

Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels

21 January 2018

1 reference

Ih blockers have a potential of antiepileptic effects

21 January 2018

1 reference

Gabapentin increases the hyperpolarization-activated cation current Ih in rat CA1 pyramidal cells

21 January 2018

1 reference

Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors.

21 January 2018

1 reference

Role of the hyperpolarization-activated current Ih in somatosensory neurons

21 January 2018

1 reference

Hyperpolarization-activated, cation-nonselective, cyclic nucleotide-modulated channel blockade alleviates mechanical allodynia and suppresses ectopic discharge in spinal nerve ligated rats

21 January 2018

1 reference

Inhibition of hyperpolarization-activated current by ZD7288 suppresses ectopic discharges of injured dorsal root ganglion neurons in a rat model of neuropathic pain.

21 January 2018

1 reference

Molecular and neuronal substrates for general anaesthetics

21 January 2018

1 reference

TASK-3 knockout mice exhibit exaggerated nocturnal activity, impairments in cognitive functions, and reduced sensitivity to inhalation anesthetics.

21 January 2018

1 reference

Multiple ionic mechanisms mediate inhibition of rat motoneurones by inhalation anaesthetics

21 January 2018

1 reference

Convergent and reciprocal modulation of a leak K+ current and I(h) by an inhalational anaesthetic and neurotransmitters in rat brainstem motoneurones

21 January 2018

1 reference

Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane

21 January 2018

1 reference

HCN subunit-specific and cAMP-modulated effects of anesthetics on neuronal pacemaker currents.

21 January 2018

1 reference

Subunit-specific effects of isoflurane on neuronal Ih in HCN1 knockout mice

21 January 2018

1 reference

Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol.

21 January 2018

1 reference

Local anesthetic inhibits hyperpolarization-activated cationic currents

21 January 2018

1 reference

Nicotine blocks the hyperpolarization-activated current Ih and severely impairs the oscillatory behavior of oriens-lacunosum moleculare interneurons.

21 January 2018

1 reference

Light responses in the mouse retina are prolonged upon targeted deletion of the HCN1 channel gene

21 January 2018

1 reference

Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f).

21 January 2018

1 reference

Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart

21 January 2018

1 reference

The pelvis-kidney junction contains HCN3, a hyperpolarization-activated cation channel that triggers ureter peristalsis

21 January 2018

1 reference

Site of origin and molecular substrate of atrioventricular junctional rhythm in the rabbit heart

21 January 2018

1 reference

HCN2 Ion Channels Play a Central Role in Inflammatory and Neuropathic Pain

21 January 2018

1 reference

Towards an integrated view of HCN channel role in epilepsy.

21 January 2018

1 reference

Inaugural editorial: a new era for Circulation Research

31 March 2020

1 reference

Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain

31 March 2020

1 reference

Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS.

31 March 2020

1 reference

Direct inhibition of Ih by analgesic loperamide in rat DRG neurons

31 March 2020

1 reference

Differential Expression of Ion Channel Transcripts in Atrial Muscle and Sinoatrial Node in Rabbit

31 March 2020

1 reference

Organisation of the mouse sinoatrial node: structure and expression of HCN channels

31 March 2020

1 reference

31 March 2020

Tripping the HCN breaker

1 reference

HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2

31 March 2020

1 reference

Control of the hyperpolarization-activated cation current by external anions in rabbit sino-atrial node cells

31 March 2020

1 reference

Pacemaker current and automatic rhythms: toward a molecular understanding.

31 March 2020

1 reference

Mechanisms of neuropathic pain

31 March 2020

1 reference

Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.

31 March 2020

1 reference

Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathy

31 March 2020

1 reference

Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart

31 March 2020

1 reference

Effect of Cardiac Resynchronization on the Incidence of Atrial Fibrillation in Patients With Severe Heart Failure

31 March 2020

1 reference

Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites

31 March 2020

1 reference

Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat

31 March 2020

1 reference

Inhibition of a hyperpolarization-activated current by clonidine in rat dorsal root ganglion neurons.

31 March 2020

1 reference

Discovery of a novel series of selective HCN1 blockers

31 March 2020

1 reference

Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22094868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modulation of the hyperpolarization-activated cation current of rat thalamic relay neurones by intracellular pH.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22094868

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3576

1 reference

PubMed ID

22094868

Dimensions Publication ID

25 August 2017

0 references

1 reference

PubMed ID

22094868