Metabolic symbiosis in cancer: refocusing the Warburg lens (Q37974107)

26 August 2017

Metabolic symbiosis in cancer: refocusing the Warburg lens (English)

1 reference

26 August 2017

Erica C Nakajima

1

1 reference

PubMed ID

22228080

26 August 2017

Bennett Van Houten

series ordinal

2

1 reference

26 August 2017

6 January 2012

1 reference

26 August 2017

Molecular Carcinogenesis

1 reference

26 August 2017

52

1 reference

26 August 2017

5

1 reference

26 August 2017

329-337

1 reference

On the Origin of Cancer Cells

26 August 2017

1 reference

Actuality of Warburg's views in our understanding of renal cancer metabolism.

21 January 2018

1 reference

Cancer cell metabolism: Warburg and beyond

21 January 2018

1 reference

Mitochondrial uncoupling and the Warburg effect: molecular basis for the reprogramming of cancer cell metabolism

21 January 2018

1 reference

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

21 January 2018

1 reference

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

21 January 2018

1 reference

Hypoxia-inducible factor-1-mediated expression of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) gene. Its possible role in the Warburg effect

21 January 2018

1 reference

Cancer metabolism: facts, fantasy, and fiction

21 January 2018

1 reference

Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited

21 January 2018

1 reference

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

Tumor acidity, chemoresistance and proton pump inhibitors.

21 January 2018

1 reference

V-ATPase inhibitors and implication in cancer treatment.

21 January 2018

1 reference

Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments

21 January 2018

1 reference

Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles

21 January 2018

1 reference

Neuron-glia metabolic coupling and plasticity

21 January 2018

1 reference

Facile detection of mitochondrial DNA mutations in tumors and bodily fluids

21 January 2018

1 reference

Somatic mutations of the mitochondrial genome in human colorectal tumours

21 January 2018

1 reference

Mitochondrial mutations in cancer

21 January 2018

1 reference

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

21 January 2018

1 reference

Brick by brick: metabolism and tumor cell growth

21 January 2018

1 reference

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

21 January 2018

1 reference

On respiratory impairment in cancer cells

21 January 2018

1 reference

Regulation of cancer cell metabolism

21 January 2018

1 reference

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

21 January 2018

1 reference

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling

21 January 2018

1 reference

Hypoxia and hypoxia-inducible factors: master regulators of metastasis

21 January 2018

1 reference

Differential prognostic impact of hypoxia induced and diffuse HIF-1alpha expression in invasive breast cancer

21 January 2018

1 reference

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia.

21 January 2018

1 reference

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

21 January 2018

1 reference

Hypoxia. 2. Hypoxia regulates cellular metabolism

21 January 2018

1 reference

Heterogeneous vascular dependence of tumor cell populations

21 January 2018

1 reference

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

Mitochondrial tumour suppressors: a genetic and biochemical update

21 January 2018

1 reference

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

21 January 2018

1 reference

AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

p53 regulates mitochondrial respiration

21 January 2018

1 reference

p53 regulation of metabolic pathways

21 January 2018

1 reference

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 January 2018

1 reference

Control of glycolysis through regulation of PFK1: old friends and recent additions

21 January 2018

1 reference

MYC, microRNAs and glutamine addiction in cancers

21 January 2018

1 reference

Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas.

21 January 2018

1 reference

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

21 January 2018

1 reference

Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts

21 January 2018

1 reference

The genomic complexity of primary human prostate cancer

21 January 2018

1 reference

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

Genome remodelling in a basal-like breast cancer metastasis and xenograft

21 January 2018

1 reference

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

21 January 2018

1 reference

Monocarboxylate transporter MCT1 is a target for immunosuppression

21 January 2018

1 reference

The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view

21 January 2018

1 reference

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

21 January 2018

1 reference

Mutant metabolic enzymes are at the origin of gliomas

21 January 2018

1 reference

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

1 reference

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

21 January 2018

1 reference

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

1 reference

Metabolism unhinged: IDH mutations in cancer.

21 January 2018

1 reference

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

21 January 2018

1 reference

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

21 January 2018

1 reference

Glutamine addiction: a new therapeutic target in cancer

21 January 2018

1 reference

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

21 January 2018

1 reference

Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cells

21 January 2018

1 reference

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

21 January 2018

1 reference

Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer

21 January 2018

1 reference

Bcl-2 antisense (oblimersen sodium) plus dacarbazine in patients with advanced melanoma: the Oblimersen Melanoma Study Group

21 January 2018

1 reference

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

21 January 2018

1 reference

The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

21 January 2018

1 reference

200th anniversary of lactate research in muscle

21 January 2018

1 reference

Lactate as a fuel for mitochondrial respiration

21 January 2018

1 reference

Cell-cell and intracellular lactate shuttles.

21 January 2018

1 reference

Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials

21 January 2018

1 reference

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

21 January 2018

1 reference

Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation

21 January 2018

1 reference

Lactate transporters (MCT proteins) in heart and skeletal muscles

21 January 2018

1 reference

Mitochondrial and plasma membrane lactate transporter and lactate dehydrogenase isoform expression in breast cancer cell lines.

21 January 2018

1 reference

Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle

21 January 2018

1 reference

Proliferating fibroblasts at the invading tumour edge of colorectal adenocarcinomas are associated with endogenous markers of hypoxia, acidity, and oxidative stress

21 January 2018

1 reference

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

21 January 2018

1 reference

Multiple functions of caveolin-1.

21 January 2018

1 reference

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

21 January 2018

1 reference

Stromal cell expression of caveolin-1 predicts outcome in breast cancer

21 January 2018

1 reference

Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts

21 January 2018

1 reference

Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics

21 January 2018

1 reference

Correlation of PET/CT findings and histopathology after neoadjuvant therapy in non-small cell lung cancer

21 January 2018

1 reference

Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions.

21 January 2018

1 reference

Revving the engine: signal transduction fuels T cell activation.

21 January 2018

1 reference

The spatial organization of proton and lactate transport in a rat brain tumor

21 January 2018

1 reference

Cellular expression of monocarboxylate transporters in the female reproductive organ of mice: implications for the genital lactate shuttle

21 January 2018

1 reference

18FDG uptake in oesophageal adenocarcinoma: linking biology and outcome

21 January 2018

1 reference

Lactate Dehydrogenase 5 Expression in Operable Colorectal Cancer: Strong Association With Survival and Activated Vascular Endothelial Growth Factor Pathway—A Report of the Tumour Angiogenesis Research Group

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MC.21863

1 reference

26 August 2017

1 reference

PubMed ID

22228080