Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies (Q37974461)

26 August 2017

Exploiting inhibitor of apoptosis proteins as therapeutic targets in hematological malignancies (English)

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26 August 2017

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26 August 2017

9 January 2012

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26 August 2017

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26 August 2017

26

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26 August 2017

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26 August 2017

1155-1165

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https://scigraph.springernature.com/pub.10.1038/leu.2012.4

26 August 2017

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Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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Tumor resistance to apoptosis

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IAP-targeted therapies for cancer

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Directing cancer cells to self-destruct with pro-apoptotic receptor agonists

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Targeting mitochondria for cancer therapy

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Survivin, cancer networks and pathway-directed drug discovery.

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New wirings in the survivin networks

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Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

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Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

21 January 2018

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Structural basis of caspase-7 inhibition by XIAP

21 January 2018

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Structural basis for the inhibition of caspase-3 by XIAP

21 January 2018

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A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

21 January 2018

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Mechanism of XIAP-mediated inhibition of caspase-9

21 January 2018

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XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Livin, a novel inhibitor of apoptosis protein family member

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Two splicing variants of a new inhibitor of apoptosis gene with different biological properties and tissue distribution pattern

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Subcellular localization determines the delicate balance between the anti- and pro-apoptotic activity of Livin

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Array-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Characteristics of the caspase-like catalytic domain of human paracaspase.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Overexpression of X-linked inhibitor of apoptosis protein (XIAP) is an independent unfavorable prognostic factor in childhood de novo acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression of IAP-family proteins in adult acute mixed lineage leukemia (AMLL).

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.4

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Structural and biochemical basis of apoptotic activation by Smac/DIABLO

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Development of Peptidomimetics Targeting IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Small-molecule pan-IAP antagonists: a patent review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Design of small-molecule peptidic and nonpeptidic Smac mimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Antisense therapy for cancer--the time of truth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting X-linked inhibitor of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Smac mimetics: implications for enhancement of targeted therapies in leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

TNF-alpha induces two distinct caspase-8 activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Smac mimetic bypasses apoptosis resistance in FADD- or caspase-8-deficient cells by priming for tumor necrosis factor α-induced necroptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Functional complementation between FADD and RIP1 in embryos and lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Novel second mitochondria-derived activator of caspases (Smac) mimetic compounds sensitize human leukemic cell lines to conventional chemotherapeutic drug-induced and death receptor-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Importance of genetics in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38- cells in a phase 1/2 study of patients with relapsed/refractory AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Targeting XIAP Bypasses Bcl-2-Mediated Resistance to TRAIL and Cooperates with TRAIL to Suppress Pancreatic Cancer Growth In vitro and In vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Novel X-linked inhibitor of apoptosis inhibiting compound as sensitizer for TRAIL-mediated apoptosis in chronic lymphocytic leukaemia with poor prognosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.4

7 January 2021

Identifiers

DOI

10.1038/LEU.2012.4

1 reference

26 August 2017

1 reference

PubMed ID

22230799