Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups (Q38333998)

2 September 2017

Deregulated apoptosis signaling in core-binding factor leukemia differentiates clinically relevant, molecular marker-independent subgroups (English)

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2 September 2017

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S C Lück

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A C Russ

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U Botzenhardt

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P Paschka

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R F Schlenk

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H Döhner

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K Döhner

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L Bullinger

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24 June 2011

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25

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11

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1728-1738

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https://scigraph.springernature.com/pub.10.1038/leu.2011.154

2 September 2017

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Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia

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Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia

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Prognostic factors and outcome of core binding factor acute myeloid leukemia patients with t(8;21) differ from those of patients with inv(16): a Cancer and Leukemia Group B study

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Individual patient data-based meta-analysis of patients aged 16 to 60 years with core binding factor acute myeloid leukemia: a survey of the German Acute Myeloid Leukemia Intergroup

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KIT mutations confer a distinct gene expression signature in core binding factor leukaemia

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Adverse prognostic significance of KIT mutations in adult acute myeloid leukemia with inv(16) and t(8;21): a Cancer and Leukemia Group B Study

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The Hallmarks of Cancer

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IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

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Inhibitor of apoptosis proteins in hematological malignancies

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

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Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

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Targeting the mitogen-activated protein kinase pathway: physiological feedback and drug response

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PAK signaling in oncogenesis.

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Cell cycle, CDKs and cancer: a changing paradigm

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Cluster analysis and display of genome-wide expression patterns

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Reversal of stathmin-mediated resistance to paclitaxel and vinblastine in human breast carcinoma cells

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An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.

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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

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Microtubule dynamics as a target in oncology

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Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

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The Bcl-2 homology domain 3 mimetic ABT-737 targets the apoptotic machinery in acute lymphoblastic leukemia resulting in synergistic in vitro and in vivo interactions with established drugs

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

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Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

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Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

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Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines

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An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer

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cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation

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IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

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RIPK1 is not essential for TNFR1-induced activation of NF-kappaB.

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

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cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

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IAP-targeted therapies for cancer

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Molecular characterization of acute myeloid leukemia

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inferred from DOI database lookup

7 January 2021

based on heuristic

The clinical spectrum of adult acute myeloid leukaemia associated with core binding factor translocations

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.154

inferred from DOI database lookup

7 January 2021

based on heuristic

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2011.154

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/LEU.2011.154

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Dimensions Publication ID

2 September 2017

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