Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis (Q37980249)

26 August 2017

Endoplasmic reticulum stress and the ER mitochondrial calcium cycle in amyotrophic lateral sclerosis (English)

1 reference

amyotrophic lateral sclerosis

26 August 2017

endoplasmic reticulum

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1 reference

3

Julian Grosskreutz

1 reference

26 August 2017

Janin Lautenschlaeger

series ordinal

1

1 reference

PubMed ID

22292840

26 August 2017

Tino Prell

series ordinal

2

1 reference

26 August 2017

1 February 2012

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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

26 August 2017

1 reference

26 August 2017

13

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26 August 2017

2

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26 August 2017

166-177

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

26 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Exome sequencing reveals VCP mutations as a cause of familial ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Novel p.Ile151Val mutation in VCP in a patient of African American descent with sporadic ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Mutations of optineurin in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Expression of an endoplasmic reticulum-resident chaperone, glucose-regulated stress protein 78, in the spinal cord of a mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Physiology and pathophysiology of the calcium store in the endoplasmic reticulum of neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Neuronal calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Calcium dysregulation in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis revealed by organelle-specific antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The Golgi apparatus of motor neurons in amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Fragmentation of the Golgi apparatus of Betz cells in patients with amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Cu/Zn superoxide dismutase typical for familial amyotrophic lateral sclerosis increases the vulnerability of mitochondria and perturbs Ca2+ homeostasis in SOD1G93A mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Mitochondria recycle Ca(2+) to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Neural mitochondrial Ca2+ capacity impairment precedes the onset of motor symptoms in G93A Cu/Zn-superoxide dismutase mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Impairment of mitochondrial calcium handling in a mtSOD1 cell culture model of motoneuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Endoplasmic reticulum stress response and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

A structural overview of the PDI family of proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Tripartite management of unfolded proteins in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Programmed cell death in amyotrophic lateral sclerosis: a mechanism of pathogenic and therapeutic importance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Apoptosis in amyotrophic lateral sclerosis: a review of the evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Altered distribution and levels of cathepsinD and cystatins in amyotrophic lateral sclerosis transgenic mice: possible roles in motor neuron survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Another way to die: autophagic programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

The molecular links between TDP-43 dysfunction and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Progressive motor weakness in transgenic mice expressing human TDP-43.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

TDP-43-induced death is associated with altered regulation of BIM and Bcl-xL and attenuated by caspase-mediated TDP-43 cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Characterization of the properties of a novel mutation in VAPB in familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

VAPB interacts with and modulates the activity of ATF6.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F17482968.2011.641569

10.3109/17482968.2011.641569

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22292840