Regulation of NF-κB by ubiquitination and degradation of the IκBs (Q37995680)

26 August 2017

Regulation of NF-κB by ubiquitination and degradation of the IκBs (English)

1 reference

26 August 2017

0 references

protein ubiquitination

1 reference

Naama Kanarek

1

1 reference

PubMed ID

22435548

26 August 2017

Yinon Ben-Neriah

series ordinal

2

1 reference

26 August 2017

1 March 2012

1 reference

26 August 2017

Immunological Reviews

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26 August 2017

246

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26 August 2017

1

1 reference

26 August 2017

77-94

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Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism

26 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Multiple nuclear factors interact with the immunoglobulin enhancer sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

It takes two to tango: IκBs, the multifunctional partners of NF-κB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

In vivo stimulation of I kappa B phosphorylation is not sufficient to activate NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Proteolytic degradation of MAD3 (I kappa B alpha) and enhanced processing of the NF-kappa B precursor p105 are obligatory steps in the activation of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Cupric ion blocks NF kappa B activation through inhibiting the signal-induced phosphorylation of I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Identification of the receptor component of the IkappaBalpha-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

In vivo half-life of a protein is a function of its amino-terminal residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Heat-inducible degron: a method for constructing temperature-sensitive mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Cyclin is degraded by the ubiquitin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Regulation of the cell cycle by SCF-type ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

CKIα ablation highlights a critical role for p53 in invasiveness control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Spermatogenesis rescue in a mouse deficient for the ubiquitin ligase SCF{beta}-TrCP by single substrate depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

RING domain E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

SCF and Cullin/Ring H2-based ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The SCF ubiquitin ligase: insights into a molecular machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The leucine-rich repeat as a protein recognition motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

E3 ubiquitin ligase that recognizes sugar chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Signal-induced ubiquitination of IkappaBalpha by the F-box protein Slimb/beta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Recruitment of a ROC1-CUL1 ubiquitin ligase by Skp1 and HOS to catalyze the ubiquitination of I kappa B alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

beta-TrCP mediates the signal-induced ubiquitination of IkappaBbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Pseudosubstrate regulation of the SCF(beta-TrCP) ubiquitin ligase by hnRNP-U

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Initial genome sequencing and analysis of multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Ubiquitination and degradation of the inhibitors of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Identification of positive and negative regulatory regions controlling expression of the Xenopus laevis betaTrCP gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Inhibition of HOS expression and activities by Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Overexpression of human beta TrCP1 deleted of its F box induces tumorigenesis in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Structural regulation of cullin-RING ubiquitin ligase complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

A RING E3–substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The nuclear ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Signaling molecules of the NF-kappa B pathway shuttle constitutively between cytoplasm and nucleus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Cytoplasmic sequestration of rel proteins by IkappaBalpha requires CRM1-dependent nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IkappaB family members function by different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Transient IkappaB kinase activity mediates temporal NF-kappaB dynamics in response to a wide range of tumor necrosis factor-alpha doses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Understanding NF-kappaB signaling via mathematical modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The processivity of multiubiquitination by the APC determines the order of substrate degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Regulation of NF-κB by deubiquitinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

New insights into NF-kappaB regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Lessons from mathematically modeling the NF-κB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

A fourth IkappaB protein within the NF-kappaB signaling module

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Introducing spatial information into predictive NF-kappaB modelling--an agent-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The precursor of NF-kappa B p50 has I kappa B-like functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Generation of p50 subunit of NF-kappa B by processing of p105 through an ATP-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Inducible nuclear expression of newly synthesized I kappa B alpha negatively regulates DNA-binding and transcriptional activities of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Duration of nuclear NF-kappaB action regulated by reversible acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Stimulus specificity of gene expression programs determined by temporal control of IKK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

UV as an amplifier rather than inducer of NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Constitutive phosphorylation of I kappa B alpha by casein kinase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Many faces of NF-kappaB signaling induced by genotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Nuclear factor-kappaB in cancer development and progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappaB in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease (*)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Expression of constitutively active IkappaB beta in T cells of transgenic mice: persistent NF-kappaB activity is required for T-cell immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Advances in targeting IKK and IKK-related kinases for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

KINK-1, a novel small-molecule inhibitor of IKKbeta, and the susceptibility of melanoma cells to antitumoral treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Development of the proteasome inhibitor Velcade (Bortezomib).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Targeting transcription factor NFkappaB: comparative analysis of proteasome and IKK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Proteasome inhibition as a novel therapeutic target in human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Oncogenically active MYD88 mutations in human lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Proteasome inhibition: a novel approach to cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Effect of structural and conformation modifications, including backbone cyclization, of hydrophilic hexapeptides on their intestinal permeability and enzymatic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

The proteasome: a suitable antineoplastic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

NF-kappaB family of transcription factors: central regulators of innate and adaptive immune functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IL-1 pathways in inflammation and human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

IL-1, IL-18, and IL-33 families of cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01098.X

10.1111/J.1600-065X.2012.01098.X

21 January 2018

Identifiers

DOI

1 reference

26 August 2017

1 reference

PubMed ID

22435548