Functional primate genomics--leveraging the medical potential (Q38007345)

26 August 2017

title

Functional primate genomics--leveraging the medical potential (English)

1 reference

26 August 2017

1 reference

1

Wolfgang Enard

1 reference

26 August 2017

publication date

4 May 2012

1 reference

Journal of Molecular Medicine

26 August 2017

published in

1 reference

26 August 2017

volume

90

1 reference

26 August 2017

issue

5

1 reference

26 August 2017

page(s)

471-480

1 reference

Evolution in health and medicine Sackler colloquium: Making evolutionary biology a basic science for medicine

26 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Harnessing evolutionary biology to combat infectious disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Evolution in health and medicine Sackler colloquium: a public choice framework for controlling transmissible and evolving diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Clonal evolution in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

New approaches to population stratification in genome-wide association studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The emergence of human-evolutionary medical genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Genome 10K: a proposal to obtain whole-genome sequence for 10,000 vertebrate species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Fundamental concepts in genetics: Genetics and the understanding of selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

A high-resolution map of human evolutionary constraint using 29 mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

A model of the statistical power of comparative genome sequence analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Massive turnover of functional sequence in human and other mammalian genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Rapid turnover of functional sequence in human and other genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Phylogenetic shadowing of primate sequences to find functional regions of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Close sequence comparisons are sufficient to identify human cis-regulatory elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Primate-specific evolution of an LDLR enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Sequencing primate genomes: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Generation of transgenic non-human primates with germline transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Linking genotypes, phenotypes, and fitness in wild primate populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Limitations of next-generation genome sequence assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The difficulty of avoiding false positives in genome scans for natural selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

A molecular phylogeny of living primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Trans genomic capture and sequencing of primate exomes reveals new targets of positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Phylogenomics of primates and their ancestral populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

A Draft Sequence of the Neandertal Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Genetic history of an archaic hominin group from Denisova Cave in Siberia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Learning about human population history from ancient and modern genomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The shaping of modern human immune systems by multiregional admixture with archaic humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Origins, evolution, and phenotypic impact of new genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Accelerated recruitment of new brain development genes into the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Genetic variants associated with Lp(a) lipoprotein level and coronary disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Convergent evolution of apolipoprotein(a) in primates and hedgehog

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Lipoprotein(a): Nonhuman primate models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Convergent evolution in primates and an insectivore.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The recurring evolution of lipoprotein(a). Insights from cloning of hedgehog apolipoprotein(a).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Evolutionary simulations to detect functional lineage-specific genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Bonobos fall within the genomic variation of chimpanzees

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Plasma lipoproteins are important components of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Plasma lipoproteins: teaching old dogmas new tricks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Molecular mechanisms of epistasis within and between genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Dobzhansky-Muller incompatibilities in protein evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Initial sequence of the chimpanzee genome and comparison with the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Triangulation of the human, chimpanzee, and Neanderthal genome sequences identifies potentially compensated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Why are some human disease-associated mutations fixed in mice?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E: From lipid transport to neurobiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E4 domain interaction: synaptic and cognitive deficits in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Evidence for hitchhiking of deleterious mutations within the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Patterns of positive selection in six Mammalian genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The role of positive selection in determining the molecular cause of species differences in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

FOXP2 and the role of cortico-basal ganglia circuits in speech and language evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Approaches for identifying targets of positive selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Population genetic inference from genomic sequence variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Recent and ongoing selection in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Constructing genomic maps of positive selection in humans: where do we go from here?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

How reliable are empirical genomic scans for selective sweeps?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Genealogical trees, coalescent theory and the analysis of genetic polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Widespread genomic signatures of natural selection in hominid evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Molecular evolution of the antiretroviral TRIM5 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Restriction of an extinct retrovirus by the human TRIM5alpha antiviral protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

From fitness landscapes to seascapes: non-equilibrium dynamics of selection and adaptation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Classic selective sweeps were rare in recent human evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Assessing the evolutionary impact of amino acid mutations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Comparative primate genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Comment on Papers by Evans et al. and Mekel-Bobrov et al. on Evidence for Positive Selection of MCPH1 and ASPM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Phenomics: the next challenge

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

NEW: network-enabled wisdom in biology, medicine, and health care

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Inferring regulatory mechanisms from patterns of evolutionary divergence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Comparative functional genomics of the fission yeasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Towards an evolutionary model of transcription networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Genotype-phenotype associations: substitution models to detect evolutionary associations between phenotypic variables and genotypic evolutionary rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Rationale and design of the Leipzig (LIFE) Heart Study: phenotyping and cardiovascular characteristics of patients with coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The evolution of gene expression levels in mammalian organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Intra- and interspecific variation in primate gene expression patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Rapid metabolic evolution in human prefrontal cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The promise of induced pluripotent stem cells in research and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Induced pluripotent stem cells from highly endangered species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Efficient generation of nonhuman primate induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Gene editing: not just for translation anymore

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

The seven deadly sins of comparative analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Linking ecological immunology and evolutionary medicine: the case for apolipoprotein E

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00109-012-0901-4

Evolution. Darwinian medicine's drawn-out dawn

21 January 2018

1 reference

12 December 2020

Chromosomal redistribution of male-biased genes in mammalian evolution with two bursts of gene gain on the X chromosome

1 reference

12 December 2020

The effect of deleterious mutations on neutral molecular variation

1 reference

12 December 2020

The signature of positive selection at randomly chosen loci.

1 reference

12 December 2020

Promiscuity and the rate of molecular evolution at primate immunity genes

1 reference

12 December 2020

Variation in Lp(a) levels and apo(a) isoform frequencies in five baboon subspecies

1 reference

12 December 2020

Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery

1 reference

12 December 2020

10.1007/S00109-012-0901-4

Identifiers

DOI

1 reference

Dimensions Publication ID

26 August 2017

1032584428

0 references

1 reference