Autologous regulatory T cells for the treatment of type 1 diabetes (Q38030480)

27 August 2017

Autologous regulatory T cells for the treatment of type 1 diabetes (English)

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27 August 2017

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James A Thompson

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27 August 2017

Daniel Perry

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2

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27 August 2017

Todd M Brusko

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3

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27 August 2017

1 October 2012

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27 August 2017

Current diabetes report

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27 August 2017

12

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27 August 2017

5

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27 August 2017

623-632

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https://scigraph.springernature.com/pub.10.1007/s11892-012-0304-5

27 August 2017

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cites work

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Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

21 January 2018

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Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase

21 January 2018

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Autoimmune Diseases as the Loss of Active “Self‐Control”

21 January 2018

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Primary immune deficiency disorders presenting as autoimmune diseases: IPEX and APECED.

21 January 2018

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Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study.

21 January 2018

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Type 1 diabetes as a relapsing-remitting disease?

21 January 2018

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Human regulatory T cells: role in autoimmune disease and therapeutic opportunities

21 January 2018

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21 January 2018

Treg in type 1 diabetes

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Analysis of islet inflammation in human type 1 diabetes.

21 January 2018

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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Expansion of Th17 cells and functional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Plasticity of CD4(+) FoxP3(+) T cells

21 January 2018

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Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

21 January 2018

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Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes.

21 January 2018

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Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.

21 January 2018

1 reference

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Regulatory T cells: stability revisited

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

A comprehensive review of interventions in the NOD mouse and implications for translation

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Reversal of nonstructural protein 3-specific CD4(+) T cell dysfunction in patients with persistent hepatitis C virus infection

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Adoptive cell therapy for the treatment of patients with metastatic melanoma

21 January 2018

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Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice

21 January 2018

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Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Polyclonal Treg cells modulate T effector cell trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Expansion of human regulatory T-cells from patients with type 1 diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Remapping the insulin gene/IDDM2 locus in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Is antigen specificity of autoreactive T cells the key to islet entry?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Human antigen-specific regulatory T cells generated by T cell receptor gene transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets

21 January 2018

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T1DBase: update 2011, organization and presentation of large-scale data sets for type 1 diabetes research

21 January 2018

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T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

PTPN22 alters the development of regulatory T cells in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Interleukin-2 receptor signaling: at the interface between tolerance and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+CD25+ regulatory T cell function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

CTLA-4: a key regulatory point in the control of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Engineering lymphocyte subsets: tools, trials and tribulations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

A simple and effective method to generate lentiviral vectors for ex vivo gene delivery to mature human peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

TCR affinity and specificity requirements for human regulatory T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Advances in imaging gene-directed enzyme prodrug therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Immune intervention in type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Combining immunotherapy and targeted therapies in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Association of CTLA4 polymorphism with regulatory T cell frequency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Shared and distinct genetic variants in type 1 diabetes and celiac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Cord blood derived CD4+ CD25(high) T cells become functional regulatory T cells upon antigen encounter

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Treatment of advanced leukemia in mice with mRNA engineered T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Comparative study of regulatory T cells expanded ex vivo from cord blood and adult peripheral blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Activation requirements for the induction of CD4+CD25+ T cell suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes. Belgian Diabetes Registry

21 January 2018

2 references

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

21 January 2018

12 December 2020

Cutting Edge: Increased IL-17-Secreting T Cells in Children with New-Onset Type 1 Diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS11892-012-0304-5

Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens

21 January 2018

1 reference

12 December 2020

Functional plasticity in human FOXP3(+) regulatory T cells: implications for cell-based immunotherapy

1 reference

12 December 2020

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

1 reference

12 December 2020

Use of CD3 antibodies in transplantation and autoimmune diseases

1 reference

12 December 2020

Activation of CD4+ CD25+ regulatory T cell suppressor function by analogs of the selecting peptide

1 reference

12 December 2020

Expansion of CD4(+)CD25 (+) regulatory T cells from cord blood CD4(+) cells using the common γ-chain cytokines (IL-2 and IL-15) and rapamycin

1 reference

12 December 2020

Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group

1 reference

12 December 2020

Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice

1 reference

12 December 2020

Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity

1 reference

12 December 2020

Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells

1 reference

12 December 2020

Comparative study of regulatory T cell function of human CD25CD4 T cells from thymocytes, cord blood, and adult peripheral blood

1 reference

12 December 2020

Low-dose rapamycin treatment increases the ability of human regulatory T cells to inhibit transplant arteriosclerosis in vivo.

1 reference

12 December 2020

Selection of regulatory T cells in the thymus

1 reference

12 December 2020

Understanding type 1 diabetes through genetics: advances and prospects

1 reference

12 December 2020

10.1007/S11892-012-0304-5

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

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