Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications (Q38074864)

28 August 2017

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title

Leptin: molecular mechanisms, systemic pro-inflammatory effects, and clinical implications (English)

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28 August 2017

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6

Julio Licinio

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28 August 2017

Gilberto Paz-Filho

1

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28 August 2017

Claudio Mastronardi

2

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28 August 2017

Carina Bertoldi Franco

3

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28 August 2017

Kevin Boyang Wang

4

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28 August 2017

Ma-Li Wong

5

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28 August 2017

1 December 2012

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Arquivos Brasileiros de Endocrinologia e Metabologia

28 August 2017

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28 August 2017

56

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28 August 2017

597-607

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28 August 2017

9

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Adipose tissue as an endocrine organ

28 August 2017

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https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Adipose tissue at the crossroads in the development of the metabolic syndrome, inflammation and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin and the regulation of body weight in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Narrative review: the role of leptin in human physiology: emerging clinical applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Congenital leptin deficiency: diagnosis and effects of leptin replacement therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Ten years of leptin replacement therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

The role of leptin in innate and adaptive immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

The weight of leptin in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Identification and expression cloning of a leptin receptor, OB-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Threading analysis suggests that the obese gene product may be a helical cytokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Defective STAT signaling by the leptin receptor in diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

The PI3K signaling pathway mediates the biological effects of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Activation of downstream signals by the long form of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Regulatory mechanisms and function of ERK MAP kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin receptor action and mechanisms of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Intracellular signalling pathways activated by leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

A family of cytokine-inducible inhibitors of signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Neuronal PTP1B regulates body weight, adiposity and leptin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

PTP1B regulates leptin signal transduction in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Regulatory T cells in obesity: the leptin connection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

21 January 2018

Leptin and Inflammation

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin induces growth hormone secretion from peripheral blood mononuclear cells via a protein kinase C- and nitric oxide-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin induces the expression of functional tissue factor in human neutrophils and peripheral blood mononuclear cells through JAK2-dependent mechanisms and TNFalpha involvement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin: at the crossroads of energy balance and systemic inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Towards a pro-inflammatory and immunomodulatory emerging role of leptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Role of leptin in the activation of immune cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

CNS leptin action modulates immune response and survival in sepsis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin: a pivotal mediator of intestinal inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Role of central leptin signaling in the starvation-induced alteration of B-cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with r

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin replacement therapy modulates circulating lymphocyte subsets and cytokine responsiveness in severe lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Adipose "talks" to distant organs to regulate insulin sensitivity and vascular function

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Adipocytokines and the metabolic complications of obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Association of serum leptin levels with homeostasis model assessment-estimated insulin resistance and metabolic syndrome: the key role of central obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin induces inflammation-related genes in RINm5F insulinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Adipose tissue, adipokines, and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

What's new in our understanding of the role of adipokines in rheumatic diseases?

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin treatment confers clinical benefit at multiple stages of virally induced type 1 diabetes in BB rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin modulates the inflammatory response in acute pancreatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

The anti-inflammatory effect of leptin on experimental colitis: involvement of endogenous glucocorticoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

Leptin consumption in the inflamed joints of patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1590%2FS0004-27302012000900001

10.1590/S0004-27302012000900001

21 January 2018

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DOI

1 reference

28 August 2017

1 reference