Sirtuin 6: a review of biological effects and potential therapeutic properties (Q38099602)

28 August 2017

Sirtuin 6: a review of biological effects and potential therapeutic properties (English)

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28 August 2017

Jade M Beauharnois

1

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28 August 2017

Beatriz E Bolívar

series ordinal

2

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28 August 2017

John T Welch

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3

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28 August 2017

language of work or name

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17 April 2013

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28 August 2017

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28 August 2017

9

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28 August 2017

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28 August 2017

1789-1806

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Regulation of SIRT6 protein levels by nutrient availability

28 August 2017

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Sirtuins: Sir2-related NAD-dependent protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Sirtuin modulators: mechanisms and potential clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3MB00001J

The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Therapeutic role of sirtuins in neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT1 and AMPK in regulating mammalian senescence: a critical review and a working model

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Recent progress in the biology and physiology of sirtuins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Structure-based development of novel sirtuin inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The first identification of lysine malonylation substrates and its regulatory enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Chromatin regulation and genome maintenance by mammalian SIRT6

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3MB00001J

Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Crystal structures of human SIRT3 displaying substrate-induced conformational changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Structure and biochemical functions of SIRT6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The Sir 2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

21 January 2018

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https://api.crossref.org/works/10.1039%2FC3MB00001J

Regulation and protection of mitochondrial physiology by sirtuins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 in DNA repair, metabolism and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Chromatin modifications: the driving force of senescence and aging?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Genomic instability--an evolving hallmark of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

POT1 as a terminal transducer of TRF1 telomere length control

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Histone H3-K56 acetylation is important for genomic stability in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The Sirtuin family: therapeutic targets to treat diseases of aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Sirtuin chemical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 promotes DNA repair under stress by activating PARP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Changes in DNA repair during aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

'Accelerated aging': a primrose path to insight?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Identification of the ADP-ribosylation sites in the PARP-1 automodification domain: analysis and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Repair of endogenous DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

DNA repair, genome stability, and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The mechanics of base excision repair, and its relationship to aging and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The ageing epigenome: damaged beyond repair?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Nucleotide excision repair disorders and the balance between cancer and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

DNA resection in eukaryotes: deciding how to fix the break

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Human CtIP promotes DNA end resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Human SIRT6 promotes DNA end resection through CtIP deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Sirtuins--novel therapeutic targets to treat age-associated diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

CtIP links DNA double-strand break sensing to resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Pathways that suppress programmed DNA breaks from progressing to chromosomal breaks and translocations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Genetics of longevity and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Insights into thymic aging and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Inflammation-associated cancer: NF-kappaB is the lynchpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Reversal of aging by NFkappaB blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Motif module map reveals enforcement of aging by continual NF-kappaB activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Aging mice show a decreasing correlation of gene expression within genetic modules

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Aging and disease: connections to sirtuins

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Airway inflammation in severe chronic obstructive pulmonary disease: relationship with lung function and radiologic emphysema.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The role of nuclear factor-kappa B in pulmonary diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Increased expression of nuclear factor-kappaB in bronchial biopsies from smokers and patients with COPD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

NAD: a master regulator of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6: a master epigenetic gatekeeper of glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Tumor cell metabolism: cancer's Achilles' heel

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Aging, adiposity, and calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Calorie restriction in nonhuman primates: effects on diabetes and cardiovascular disease risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

SIRT6 protects against pathological damage caused by diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Synthesis and characterization of SIRT6 protein coated magnetic beads: identification of a novel inhibitor of SIRT6 deacetylase from medicinal plant extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Effects of fenugreek seed extract in obese mice fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Inhibitors of NAD+ dependent histone deacetylases (sirtuins).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Histone deacetylase inhibitors--a new tool to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

From broken to old: DNA damage, IGF1 endocrine suppression and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Fluorescence in situ hybridization and chromosomal organization of the sirtuin 4 gene (Sirt4) in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

CBP/p300-mediated acetylation of histone H3 on lysine 56

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

Sirtuins at the breaking point: SIRT6 in DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

When Sirtuins and NF-κB Collide

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC3MB00001J

21 January 2018

Identifiers

DOI

10.1039/C3MB00001J

1 reference

28 August 2017

1 reference