Hedgehog signaling pathway and cancer therapeutics: progress to date (Q38100713)

28 August 2017

title

Hedgehog signaling pathway and cancer therapeutics: progress to date (English)

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28 August 2017

Joshua M Ruch

1

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28 August 2017

Edward J Kim

series ordinal

2

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28 August 2017

publication date

1 May 2013

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28 August 2017

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28 August 2017

volume

73

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28 August 2017

issue

7

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28 August 2017

page(s)

613-623

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

28 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

21 January 2018

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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer

21 January 2018

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Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signaling in animal development: paradigms and principles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Mutations affecting segment number and polarity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Targeting the Hedgehog pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Tissue repair and stem cell renewal in carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Molecular pathways: the hedgehog signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Gli proteins in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Vertebrate Smoothened functions at the primary cilium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Identification of an amplified, highly expressed gene in a human glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Multiple nevoid basal-cell epithelioma, jaw cysts and bifid rib. A syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Human homolog of patched, a candidate gene for the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Activating Smoothened mutations in sporadic basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Mutations in SUFU predispose to medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signalling in prostate regeneration, neoplasia and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Paracrine Hedgehog signaling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

A paracrine requirement for hedgehog signalling in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Pancreatic cancer and precursor pancreatic intraepithelial neoplasia lesions are devoid of primary cilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Essential role of stromally induced hedgehog signaling in B-cell malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

The Hedgehog and Wnt signalling pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Identification of pancreatic cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog Pathway Antagonist 5E1 Binds Hedgehog at the Pseudo-active Site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

A small molecule that binds Hedgehog and blocks its signaling in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signaling drives cellular survival in human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Inhibition of the hedgehog pathway in advanced basal-cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Pharmacokinetic dose-scheduling study of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with locally advanced or metastatic solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Efficacy and safety of vismodegib in advanced basal-cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Inhibiting the hedgehog pathway in patients with the basal-cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Topical treatment of Basal cell carcinomas in nevoid Basal cell carcinoma syndrome with a smoothened inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Targeting hedgehog in hematologic malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

A frequent activated smoothened mutation in sporadic basal cell carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

The EWS/FLI1 oncogenic transcription factor deregulates GLI1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Hedgehog signaling maintains chemoresistance in myeloid leukemic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Polymeric nanoparticle-encapsulated hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Role of hedgehog signaling in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS40265-013-0045-Z

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23605693

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Frequent requirement of hedgehog signaling in non-small cell lung carcinoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23605693

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Sporadic medulloblastomas contain PTCH mutations.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23605693

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S40265-013-0045-Z

1 reference

Dimensions Publication ID

28 August 2017

1041266987

0 references

1 reference